Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Hashim Javaid"'
Publikováno v:
In Tetrahedron 24 December 2001 57(52):10329-10333
Publikováno v:
Synthetic Communications. 33:29-41
The syntheses of 2-butyl-4,5-dimethylcyclopent-4-ene-1,3-dione, possessing a buttery jasmine odor, and a series of analogues have been carried out via the synthesis of butenolactones, with subsequent conversion to 4,5-dimethylcyclopent-4-ene-1,3-dion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32daf4d9c51ff1cf3885c07971d28786
https://doi.org/10.1081/scc-120015556
https://doi.org/10.1081/scc-120015556
Publikováno v:
Tetrahedron Letters. 42:7325-7328
The addition of chiral 2-propenylphosphonamide anions, generated from the reaction products of (1 R ,2 S )-ephedrine and 2-propene-1-phosphonyl dichloride, to α-substituted cyclopentenones is described. Ozonolysis of the addition products led to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f74079c550e58f3d20a438f0ad79cd23
https://doi.org/10.1016/s0040-4039(01)01437-x
https://doi.org/10.1016/s0040-4039(01)01437-x
Autor:
Michael D. Threadgill, Niall M. B. Martin, Mary F. Mahon, Archana Dhami, Peter T. Sunderland, Esther C. Y. Woon, Hashim Javaid, Aoife B Bergin, Pauline J. Wood, Sophie R. Tully, Matthew D. Lloyd, Andrew S. Thompson, Louise A. Jones
Publikováno v:
Sunderland, P T, Woon, E C Y, Dhami, A, Bergin, A B, Mahon, M F, Wood, P J, Jones, L A, Tully, S R, Lloyd, M D, Thompson, A S, Javaid, H, Martin, N M B & Threadgill, M D 2011, ' 5-benzamidoisoquinolin-1-ones and 5-(ω-carboxyalkyl)isoquinolin-1-ones as isoform-selective inhibitors of poly(ADP-ribose) polymerase 2 (PARP-2) ', Journal of Medicinal Chemistry, vol. 54, no. 7, pp. 2049-2059 . https://doi.org/10.1021/jm1010918
PARP-2 is a member of the poly(ADP-ribose) polymerase family, with some activities similar to those of PARP-1 but with other distinct roles. Two series of isoquinolin-1-ones were designed, synthesized, and evaluated as selective inhibitors of PARP-2,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c4c060f6be8e4bbca983f3bad99defe
https://pubmed.ncbi.nlm.nih.gov/21417348
https://pubmed.ncbi.nlm.nih.gov/21417348
Autor:
Niall M. B. Martin, Michael D. Threadgill, Louise A. Jones, Sophie R. Tully, Mary F. Mahon, Peter T. Sunderland, Hashim Javaid, Archana Dhami, Matthew D. Lloyd, Andrew S. Thompson
Publikováno v:
Sunderland, P T, Dhami, A, Mahon, M F, Jones, L A, Tully, S R, Lloyd, M D, Thompson, A S, Javaid, H, Martin, N M B & Threadgill, M D 2011, ' Synthesis of 4-alkyl-, 4-aryl-and 4-arylamino-5-aminoisoquinolin-1-ones and identification of a new PARP-2 selective inhibitor ', Organic and Biomolecular Chemistry, vol. 9, no. 3, pp. 881-891 . https://doi.org/10.1039/c0ob00665c
The considerable interest in substituted isoquinolin-1-ones related to 5-aminoisoquinolin-1-one (5-AIQ) as drugs points to a need for an efficient and straightforward synthesis of the 4,5-disubstituted bicycles. Bromination of 5-nitroisoquinolin-1-on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15fd5dc066e7e16ba6a4b916fa70e72b
https://pubmed.ncbi.nlm.nih.gov/21127791
https://pubmed.ncbi.nlm.nih.gov/21127791
Publikováno v:
ChemInform. 33
The addition of chiral 2-propenylphosphonamide anions, generated from the reaction products of (1 R ,2 S )-ephedrine and 2-propene-1-phosphonyl dichloride, to α-substituted cyclopentenones is described. Ozonolysis of the addition products led to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cfe7add5c00f76729d00b73461317fc
https://doi.org/10.1002/chin.200202188
https://doi.org/10.1002/chin.200202188
Autor:
Claire Adcock, Francisco Cuenca Alonso, Niall M. B. Martin, Chris Mydlowski, Kristel Blackburn, Keith Allan Menear, Louise Copsey, Armelle Le Gall, Sylvie Gomez, Graeme C. M. Smith, Carlos Fenandez Lence, Hashim Javaid, Jan Drzewiecki, Alexandra Fundo
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(14)
We have previously described poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors based on a substituted benzyl-phthalazinone scaffold. As an alternative chemical template, a novel series of alkoxybenzamides were developed with restricted conformation t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0764f908b9acc17224a50fba6d1f26aa
https://pubmed.ncbi.nlm.nih.gov/18579376
https://pubmed.ncbi.nlm.nih.gov/18579376
Autor:
Keith A. Menear, Niall M. B. Martin, Claire Adcock, Robert Boulter, Xiao-ling Cockcroft, Louise Copsey, Aaron Cranston, Krystyna J. Dillon, Jan Drzewiecki, Sheila Garman, Sylvie Gomez, Hashim Javaid, Frank Kerrigan, Charlotte Knights, Alan Lau, Vincent M. Loh Jr., Ian T. W. Matthews, Stephen Moore, Mark J. O’Connor, Graeme C. M. Smith
Publikováno v:
Journal of Medicinal Chemistry; Oct2008, Vol. 51 Issue 20, p6581-6591, 11p
Publikováno v:
Synthetic Communications; 2003, Vol. 33 Issue 1, p29-41, 13p