Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Hashem Etayash"'
Autor:
Mauricio Gonçalves da Costa Sousa, Gabriela Conceição de Almeida, Danilo César Martins Mota, Rosiane Andrade da Costa, Simoni Campos Dias, Samuel Nunes Limberger, Frank Ko, Li Ting Lin, Evan F. Haney, Hashem Etayash, Beverlie Baquir, Michael J. Trimble, Ya Shen, Zheng Su, Markus Haapasalo, Daniel Pletzer, Letícia Chaves de Souza, Gláucia Schuindt Teixeira, Renato M. Silva, Robert E.W. Hancock, Octavio Luiz Franco, Taia Maria Berto Rezende
Publikováno v:
Bioactive Materials, Vol 16, Iss , Pp 173-186 (2022)
Multifunctional scaffolds with host defense peptides designed for regenerative endodontics are desirable nanobiotechnological tools for dentistry. Here, different scaffolds were tested for use during the pulp revascularization process, including poly
Externí odkaz:
https://doaj.org/article/383fc7caaba444be93bf353d6191ba66
Impacts of PEGylation and Glycosylation on the Biological Properties of Host Defense Peptide IDR1018
Publikováno v:
Pharmaceutics, Vol 15, Iss 5, p 1391 (2023)
The multifunctional properties of host defense peptides (HDPs) make them promising drug candidates to tackle bacterial infections and tissue inflammation. However, these peptides tend to aggregate and can harm host cells at high doses, potentially li
Externí odkaz:
https://doaj.org/article/8192e2149d6f4897bc0d03876cca8b8c
Autor:
Alberto Baldelli, Hashem Etayash, Hale Oguzlu, Ronit Mandal, Feng Jiang, Robert E.W. Hancock, Anubhav Pratap-Singh
Publikováno v:
Chemical Engineering Journal Advances, Vol 10, Iss , Pp 100273- (2022)
Spray-dried nanoparticle-in-microsphere formulations, composed of aluminum oxide nanoparticles (NPs), zinc oxide, zinc oxide NPs and cellulose nanocrystals (CNCs), with potent antimicrobial and antibiofilm activity against Gram-negative and Gram-posi
Externí odkaz:
https://doaj.org/article/83f1ecf0c8fd419eb6058a775d119a5c
Autor:
Hashem Etayash, Robert E. W. Hancock
Publikováno v:
Pharmaceutics, Vol 13, Iss 11, p 1820 (2021)
Amphiphilic antimicrobial polymers have attracted considerable interest as structural mimics of host defense peptides (HDPs) that provide a broad spectrum of activity and do not induce bacterial-drug resistance. Likewise, surface engineered polymeric
Externí odkaz:
https://doaj.org/article/064cf201eb914eb9afb699ac4423b887
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Analysis of bacteria and their response to antibiotics in real time is challenging. Here the authors report a microcantilever based system that can detect and discriminate between bacteria species and, due to the ability to discriminate between alive
Externí odkaz:
https://doaj.org/article/bdd41d4cc5004bc4b5cc35f98872b417
Publikováno v:
Nature Protocols. 16:1850-1870
Peptides are promising drug candidates because of their diversity, biocompatibility and spectrum of activities. Here, we describe a protocol for high-throughput screening of SPOT-peptide arrays to assess the antibiofilm, antimicrobial and immunomodul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17ae548d97a96db304882470a3bdb1f4
https://doi.org/10.1038/s41596-021-00500-w
https://doi.org/10.1038/s41596-021-00500-w
Autor:
Qiang Zhang, Pengcheng Ma, Ruxin Cui, Runhui Liu, Hashem Etayash, Robert E. W. Hancock, Yuxin Qian, Jiayang Xie, Fan Qi, Daniel Pletzer, Chengzhi Dai
Publikováno v:
Journal of Medicinal Chemistry. 63:12921-12928
Therapeutic options to treat multidrug resistant bacteria, especially when present in biofilms, are limited due to their high levels of antibiotic resistance. Here, we report the anti-biofilm and i...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88b6da0bec6023b057558c40816f1da0
https://doi.org/10.1021/acs.jmedchem.0c01321
https://doi.org/10.1021/acs.jmedchem.0c01321
Publikováno v:
Journal of Medicinal Chemistry. 63:9228-9236
Host-defense peptides have drawn significant attention as new drugs or drug adjuvants to combat multidrug-resistant bacteria. In this study, we report the development of cyclic derivatives of the immunomodulatory and antibiofilm innate defense regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc571e3d76817ce7212a6cad5eb98070
https://doi.org/10.1021/acs.jmedchem.0c00303
https://doi.org/10.1021/acs.jmedchem.0c00303
Autor:
Alberto Baldelli, Hashem Etayash, Hale Oguzlu, Ronit Mandal, Feng Jiang, Robert E. W. Hancock, Anubhav Pratap-Singh
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26c31fe36f3397ce47cd4c82a42acc4e
https://doi.org/10.2139/ssrn.4020838
https://doi.org/10.2139/ssrn.4020838
Autor:
Robert E. W. Hancock, Noushin Akhoundsadegh, Morgan A. Alford, Hashem Etayash, Matthew Drayton, Suzana K. Straus
Publikováno v:
Journal of medicinal chemistry. 64(22)
Effective anti-infective therapies are required to offset the rise in antibiotic resistance. A novel vancomycin-innate defense regulator conjugate (V-IDR1018) was constructed with multimodal functionality, including bacterial killing, biofilm eradica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff2c577e50c26a5de40b073e822174d1
https://pubmed.ncbi.nlm.nih.gov/35048687
https://pubmed.ncbi.nlm.nih.gov/35048687