Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Hashem, Koohy"'
Autor:
Chloe H. Lee, Jaesung Huh, Paul R. Buckley, Myeongjun Jang, Mariana Pereira Pinho, Ricardo A. Fernandes, Agne Antanaviciute, Alison Simmons, Hashem Koohy
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-24 (2023)
Abstract Background T-cells play a crucial role in the adaptive immune system by triggering responses against cancer cells and pathogens, while maintaining tolerance against self-antigens, which has sparked interest in the development of various T-ce
Externí odkaz:
https://doaj.org/article/e4fa26aaefb94dcb8391be6331e31555
Autor:
Anna Aulicino, Agne Antanaviciute, Joe Frost, Ana Sousa Geros, Esther Mellado, Moustafa Attar, Marta Jagielowicz, Philip Hublitz, Julia Sinz, Lorena Preciado-Llanes, Giorgio Napolitani, Rory Bowden, Hashem Koohy, Hal Drakesmith, Alison Simmons
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-17 (2022)
Aulicino, Antanaviciute et al investigate the transcriptional response to invasive Salmonella strains in dendritic cells (DCs). They show that S. Typhi mount a response against nitrosative stress pathways and propose a role of iron uptake and transpo
Externí odkaz:
https://doaj.org/article/26c225ac2f684651825e4bab14553e42
Autor:
Vadim Karnaukhov, Wayne Paes, Isaac B. Woodhouse, Thomas Partridge, Annalisa Nicastri, Simon Brackenridge, Dmitrii Shcherbinin, Dmitry M. Chudakov, Ivan V. Zvyagin, Nicola Ternette, Hashem Koohy, Persephone Borrow, Mikhail Shugay
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Human leukocyte antigen (HLA) genes are the most polymorphic loci in the human genome and code for proteins that play a key role in guiding adaptive immune responses by presenting foreign and self peptides (ligands) to T cells. Each person carries up
Externí odkaz:
https://doaj.org/article/8f742cced08646d3ae70b82baf33b46c
Autor:
Chloe H. Lee, Mariana Pereira Pinho, Paul R. Buckley, Isaac B. Woodhouse, Graham Ogg, Alison Simmons, Giorgio Napolitani, Hashem Koohy
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
While individuals infected with coronavirus disease 2019 (COVID-19) manifested a broad range in susceptibility and severity to the disease, the pre-existing immune memory to related pathogens cross-reactive against SARS-CoV-2 can influence the diseas
Externí odkaz:
https://doaj.org/article/cb5d6cdd7c3f41198aaa107f502f7680
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Adaptive immune recognition is mediated by specific interactions between heterodimeric T cell receptors (TCRs) and their cognate peptide-MHC (pMHC) ligands, and the methods to accurately predict TCR:pMHC interaction would have profound clinical, ther
Externí odkaz:
https://doaj.org/article/7ebdfb8b811347709b53843cc76d9ae5
Autor:
Chloe H. Lee, Hashem Koohy
Publikováno v:
F1000Research, Vol 9 (2020)
Background: The newly identified coronavirus known as 2019-nCoV has posed a serious global health threat. According to the latest report (18-February-2020), it has infected more than 72,000 people globally and led to deaths of more than 1,016 people
Externí odkaz:
https://doaj.org/article/88c126f2005240259c44a9a29ef8d0c2
Autor:
Chloe Hyun-Jung Lee, Hashem Koohy
Publikováno v:
F1000Research, Vol 9 (2020)
Background: The newly identified coronavirus known as 2019-nCoV has posed a serious global health threat. According to the latest report (18-February-2020), it has infected more than 72,000 people globally and led to deaths of more than 1,016 people
Externí odkaz:
https://doaj.org/article/2e9c296c9e1b490ab1122e742090068e
Autor:
Hashem Koohy, Daniel J. Bolland, Louise S. Matheson, Stefan Schoenfelder, Claudia Stellato, Andrew Dimond, Csilla Várnai, Peter Chovanec, Tamara Chessa, Jeremy Denizot, Raquel Manzano Garcia, Steven W. Wingett, Paula Freire-Pritchett, Takashi Nagano, Phillip Hawkins, Len Stephens, Sarah Elderkin, Mikhail Spivakov, Peter Fraser, Anne E. Corcoran, Patrick D. Varga-Weisz
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-24 (2018)
Abstract Background Aging is characterized by loss of function of the adaptive immune system, but the underlying causes are poorly understood. To assess the molecular effects of aging on B cell development, we profiled gene expression and chromatin f
Externí odkaz:
https://doaj.org/article/6176506a0b014dd1a2e2a5beb2a2e029
Autor:
Paul R. Buckley, Chloe H. Lee, Mariana Pereira Pinho, Rosana Ottakandathil Babu, Jeongmin Woo, Agne Antanaviciute, Alison Simmons, Graham Ogg, Hashem Koohy
Publikováno v:
Immunology. 166:78-103
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50600b092685719db731891e147766ac
https://doi.org/10.1111/imm.13451
https://doi.org/10.1111/imm.13451
Autor:
Daniel J. Bolland, Hashem Koohy, Andrew L. Wood, Louise S. Matheson, Felix Krueger, Michael J.T. Stubbington, Amanda Baizan-Edge, Peter Chovanec, Bryony A. Stubbs, Kristina Tabbada, Simon R. Andrews, Mikhail Spivakov, Anne E. Corcoran
Publikováno v:
Cell Reports, Vol 15, Iss 11, Pp 2475-2487 (2016)
Variable (V), diversity (D), and joining (J) (V(D)J) recombination is the first determinant of antigen receptor diversity. Understanding how recombination is regulated requires a comprehensive, unbiased readout of V gene usage. We have developed VDJ
Externí odkaz:
https://doaj.org/article/2754b12283b14484b5441338b9c3ac7a