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Autor:
Cacheiro, Pilar, Westerberg, Carl Henrik, Mager, Jesse, Dickinson, Mary E., Nutter, Lauryl M. J., Muñoz-Fuentes, Violeta, Hsu, Chih-Wei, Van den Veyver, Ignatia B., Flenniken, Ann M., McKerlie, Colin, Murray, Stephen A., Teboul, Lydia, Heaney, Jason D., Lloyd, K. C. Kent, Lanoue, Louise, Braun, Robert E., White, Jacqueline K., Creighton, Amie K., Laurin, Valerie, Guo, Ruolin, Qu, Dawei, Wells, Sara, Cleak, James, Bunton-Stasyshyn, Rosie, Stewart, Michelle, Harrisson, Jackie, Mason, Jeremy, Haseli Mashhadi, Hamed, Parkinson, Helen, Mallon, Ann-Marie, Smedley, Damian
Additional file 2: Fig. S1. WoL and cell essentiality scores. Fig. S2. WoL and cell essentiality categorisation. Fig. S3. WoL and additional gene features. Fig. S4. WoL and paralogues features. Fig. S5. WoL and additional disease features. Fig. S6. P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::368a4e85283005d1b84845ee7e2f71d0
Autor:
Cacheiro, Pilar, Westerberg, Carl Henrik, Mager, Jesse, Dickinson, Mary E., Nutter, Lauryl M. J., Muñoz-Fuentes, Violeta, Hsu, Chih-Wei, Van den Veyver, Ignatia B., Flenniken, Ann M., McKerlie, Colin, Murray, Stephen A., Teboul, Lydia, Heaney, Jason D., Lloyd, K. C. Kent, Lanoue, Louise, Braun, Robert E., White, Jacqueline K., Creighton, Amie K., Laurin, Valerie, Guo, Ruolin, Qu, Dawei, Wells, Sara, Cleak, James, Bunton-Stasyshyn, Rosie, Stewart, Michelle, Harrisson, Jackie, Mason, Jeremy, Haseli Mashhadi, Hamed, Parkinson, Helen, Mallon, Ann-Marie, Smedley, Damian
Additional file 1: Table S1. Gene features: Human cellular essential genes. Table S2. Gene features: Gene expression in human brain. Table S3. Gene features: Intolerance to variation metrics and paralogues. Table S4. Disease features. Table S5. HPO p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65a06754aabcc03739326c4893695fcb
Autor:
Cacheiro P; William Harvey Research Institute, Queen Mary University of London, London, UK., Westerberg CH; MRC Harwell Institute, Harwell, Oxfordshire, UK., Mager J; Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA, USA., Dickinson ME; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Nutter LMJ; The Hospital for Sick Children, The Centre for Phenogenomics, Toronto, Canada., Muñoz-Fuentes V; European Molecular Biology Laboratory-European Bioinformatics Institute, Hinxton, UK., Hsu CW; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA.; Department of Education, Innovation and Technology, Baylor College of Medicine, Houston, TX, USA., Van den Veyver IB; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.; Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, USA., Flenniken AM; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, The Centre for Phenogenomics, Toronto, Canada., McKerlie C; The Hospital for Sick Children, The Centre for Phenogenomics, Toronto, Canada., Murray SA; The Jackson Laboratory, Bar Harbor, ME, USA., Teboul L; The Mary Lyon Centre, MRC Harwell Institute, Harwell, Oxfordshire, UK., Heaney JD; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Lloyd KCK; Mouse Biology Program, University of California Davis, Davis, CA, USA., Lanoue L; Mouse Biology Program, University of California Davis, Davis, CA, USA., Braun RE; The Jackson Laboratory, Bar Harbor, ME, USA., White JK; The Jackson Laboratory, Bar Harbor, ME, USA., Creighton AK; The Hospital for Sick Children, The Centre for Phenogenomics, Toronto, Canada., Laurin V; The Hospital for Sick Children, The Centre for Phenogenomics, Toronto, Canada., Guo R; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, The Centre for Phenogenomics, Toronto, Canada., Qu D; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, The Centre for Phenogenomics, Toronto, Canada., Wells S; The Mary Lyon Centre, MRC Harwell Institute, Harwell, Oxfordshire, UK., Cleak J; The Mary Lyon Centre, MRC Harwell Institute, Harwell, Oxfordshire, UK., Bunton-Stasyshyn R; The Mary Lyon Centre, MRC Harwell Institute, Harwell, Oxfordshire, UK., Stewart M; The Mary Lyon Centre, MRC Harwell Institute, Harwell, Oxfordshire, UK., Harrisson J; The Mary Lyon Centre, MRC Harwell Institute, Harwell, Oxfordshire, UK., Mason J; European Molecular Biology Laboratory-European Bioinformatics Institute, Hinxton, UK., Haseli Mashhadi H; European Molecular Biology Laboratory-European Bioinformatics Institute, Hinxton, UK., Parkinson H; European Molecular Biology Laboratory-European Bioinformatics Institute, Hinxton, UK., Mallon AM; MRC Harwell Institute, Harwell, Oxfordshire, UK., Smedley D; William Harvey Research Institute, Queen Mary University of London, London, UK. d.smedley@qmul.ac.uk.
Publikováno v:
Genome medicine [Genome Med] 2022 Oct 13; Vol. 14 (1), pp. 119. Date of Electronic Publication: 2022 Oct 13.
Autor:
Spielmann N; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Center Munich (GmbH), German Research Center for Environmental Health, Neuherberg, Germany., Miller G; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Center Munich (GmbH), German Research Center for Environmental Health, Neuherberg, Germany., Oprea TI; Department of Internal Medicine, Division of Translational Informatics and Center of Biomedical Research Excellence in Autophagy, Inflammation, and Metabolism, UNM Health Sciences Center and UNM Comprehensive Cancer Center, Albuquerque, NM, USA.; Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Hsu CW; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA., Fobo G; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Center Munich (GmbH), German Research Center for Environmental Health, Neuherberg, Germany., Frishman G; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Center Munich (GmbH), German Research Center for Environmental Health, Neuherberg, Germany., Montrone C; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Center Munich (GmbH), German Research Center for Environmental Health, Neuherberg, Germany., Haseli Mashhadi H; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, UK., Mason J; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, UK., Munoz Fuentes V; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, UK., Leuchtenberger S; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Center Munich (GmbH), German Research Center for Environmental Health, Neuherberg, Germany., Ruepp A; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Center Munich (GmbH), German Research Center for Environmental Health, Neuherberg, Germany., Wagner M; Institut für Humangenetik, Technische Universität Munich, Munich, Germany., Westphal DS; Institut für Humangenetik, Technische Universität Munich, Munich, Germany.; Klinik und Poliklinik Innere Medizin I, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany., Wolf C; Department of Congenital Heart Defects and Pediatric Cardiology, German Heart Center Munich, Technical University Munich, Munich, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany., Görlach A; Experimental and Molecular Pediatric Cardiology, German Heart Center Munich, Technical University Munich, Munich, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Munich, Munich, Germany., Sanz-Moreno A; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Center Munich (GmbH), German Research Center for Environmental Health, Neuherberg, Germany., Cho YL; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Center Munich (GmbH), German Research Center for Environmental Health, Neuherberg, Germany., Teperino R; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Center Munich (GmbH), German Research Center for Environmental Health, Neuherberg, Germany., Brandmaier S; Research Unit of Molecular Epidemiology, Institute of Epidemiology II, Helmholtz Zentrum Munich, Munich, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Sharma S; Research Unit of Molecular Epidemiology, Institute of Epidemiology II, Helmholtz Zentrum Munich, Munich, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Galter IR; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Center Munich (GmbH), German Research Center for Environmental Health, Neuherberg, Germany., Östereicher MA; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Center Munich (GmbH), German Research Center for Environmental Health, Neuherberg, Germany., Zapf L; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Center Munich (GmbH), German Research Center for Environmental Health, Neuherberg, Germany., Mayer-Kuckuk P; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Center Munich (GmbH), German Research Center for Environmental Health, Neuherberg, Germany., Rozman J; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Czech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic., Teboul L; Mammalian Genetics Unit and Mary Lyon Centre, Medical Research Council Harwell Institute, Harwell, UK., Bunton-Stasyshyn RKA; Mammalian Genetics Unit and Mary Lyon Centre, Medical Research Council Harwell Institute, Harwell, UK., Cater H; Mammalian Genetics Unit and Mary Lyon Centre, Medical Research Council Harwell Institute, Harwell, UK., Stewart M; Mammalian Genetics Unit and Mary Lyon Centre, Medical Research Council Harwell Institute, Harwell, UK., Christou S; Mammalian Genetics Unit and Mary Lyon Centre, Medical Research Council Harwell Institute, Harwell, UK., Westerberg H; Mammalian Genetics Unit and Mary Lyon Centre, Medical Research Council Harwell Institute, Harwell, UK., Willett AM; The Jackson Laboratory, Bar Harbor, ME, USA., Wotton JM; The Jackson Laboratory, Bar Harbor, ME, USA., Roper WB; The Jackson Laboratory, Bar Harbor, ME, USA., Christiansen AE; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA., Ward CS; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA., Heaney JD; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA., Reynolds CL; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA., Prochazka J; Czech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic., Bower L; Mouse Biology Program, University of California, Davis, Davis, CA, USA., Clary D; Mouse Biology Program, University of California, Davis, Davis, CA, USA., Selloum M; Université de Strasbourg, CNRS, INSERM, IGBMC, Institut Clinique de la Souris, PHENOMIN-ICS, Illkirch, France., Bou About G; Université de Strasbourg, CNRS, INSERM, IGBMC, Institut Clinique de la Souris, PHENOMIN-ICS, Illkirch, France., Wendling O; Université de Strasbourg, CNRS, INSERM, IGBMC, Institut Clinique de la Souris, PHENOMIN-ICS, Illkirch, France., Jacobs H; Université de Strasbourg, CNRS, INSERM, IGBMC, Institut Clinique de la Souris, PHENOMIN-ICS, Illkirch, France., Leblanc S; Université de Strasbourg, CNRS, INSERM, IGBMC, Institut Clinique de la Souris, PHENOMIN-ICS, Illkirch, France., Meziane H; Université de Strasbourg, CNRS, INSERM, IGBMC, Institut Clinique de la Souris, PHENOMIN-ICS, Illkirch, France., Sorg T; Université de Strasbourg, CNRS, INSERM, IGBMC, Institut Clinique de la Souris, PHENOMIN-ICS, Illkirch, France., Audain E; Department of Congenital Heart Disease and Pediatric Cardiology, University Hospital of Schleswig-Holstein, Kiel, Germany.; German Center for Cardiovascular Research (DZHK), Kiel, Germany., Gilly A; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Rayner NW; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Hitz MP; Department of Congenital Heart Disease and Pediatric Cardiology, University Hospital of Schleswig-Holstein, Kiel, Germany.; German Center for Cardiovascular Research (DZHK), Kiel, Germany.; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Zeggini E; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; TUM School of Medicine, Technical University of Munich and Klinikum Rechts der Isar, Munich, Germany., Wolf E; Institute of Molecular Animal Breeding and Biotechnology, Gene Center, Ludwig-Maximilians-University Munich, Munich, Germany., Sedlacek R; Czech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic., Murray SA; The Jackson Laboratory, Bar Harbor, ME, USA., Svenson KL; The Jackson Laboratory, Bar Harbor, ME, USA., Braun RE; The Jackson Laboratory, Bar Harbor, ME, USA., White JK; The Jackson Laboratory, Bar Harbor, ME, USA., Kelsey L; The Centre for Phenogenomics, Toronto, Ontario, Canada.; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada., Gao X; SKL of Pharmaceutical Biotechnology and Model Animal Research Center, Collaborative Innovation Center for Genetics and Development, Nanjing Biomedical Research Institute, Nanjing University, Nanjing, China., Shiroishi T; RIKEN BioResource Center, Tsukuba, Japan., Xu Y; Cambridge-Suda Genomic Research Center, Soochow University, Suzhou, China., Seong JK; Korea Mouse Phenotyping Consortium (KMPC) and BK21 Program for Veterinary Science, Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, South Korea., Mammano F; CNR Institute of Biochemistry and Cell Biology, Monterotondo, Rome, Italy., Tocchini-Valentini GP; CNR Institute of Biochemistry and Cell Biology, Monterotondo, Rome, Italy., Beaudet AL; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA., Meehan TF; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, UK., Parkinson H; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, UK., Smedley D; William Harvey Research Institute, Charterhouse Square Barts and the London School of Medicine and Dentistry Queen Mary University of London, London, UK., Mallon AM; Mammalian Genetics Unit and Mary Lyon Centre, Medical Research Council Harwell Institute, Harwell, UK., Wells SE; Mammalian Genetics Unit and Mary Lyon Centre, Medical Research Council Harwell Institute, Harwell, UK., Grallert H; Research Unit of Molecular Epidemiology, Institute of Epidemiology II, Helmholtz Zentrum Munich, Munich, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Wurst W; Institute of Developmental Genetics, Helmholtz Zentrum Munich, German Research Center for Environmental Health GmbH, Neuherberg, Germany.; Department of Developmental Genetics, TUM School of Life Sciences, Technische Universität Munich, Freising, Germany.; Deutsches Institut für Neurodegenerative Erkrankungen (DZNE) Site Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Adolf-Butenandt-Institut, Ludwig-Maximilians-Universität Munich, Munich, Germany., Marschall S; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Center Munich (GmbH), German Research Center for Environmental Health, Neuherberg, Germany., Fuchs H; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Center Munich (GmbH), German Research Center for Environmental Health, Neuherberg, Germany., Brown SDM; Mammalian Genetics Unit and Mary Lyon Centre, Medical Research Council Harwell Institute, Harwell, UK., Flenniken AM; The Centre for Phenogenomics, Toronto, Ontario, Canada.; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada., Nutter LMJ; The Centre for Phenogenomics, Toronto, Ontario, Canada.; The Hospital for Sick Children, Toronto, Ontario, Canada., McKerlie C; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.; The Hospital for Sick Children, Toronto, Ontario, Canada., Herault Y; Université de Strasbourg, CNRS, INSERM, IGBMC, Institut Clinique de la Souris, PHENOMIN-ICS, Illkirch, France.; Université de Strasbourg, CNRS, INSERM, Institut de Génétique Biologie Moléculaire et Cellulaire, IGBMC, Illkirch, France., Lloyd KCK; Mouse Biology Program, University of California, Davis, Davis, CA, USA.; Department of Surgery, School of Medicine, University of California, Davis, Davis, CA, USA., Dickinson ME; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA., Gailus-Durner V; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Center Munich (GmbH), German Research Center for Environmental Health, Neuherberg, Germany., Hrabe de Angelis M; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Center Munich (GmbH), German Research Center for Environmental Health, Neuherberg, Germany. hrabe@helmholtz-muenchen.de.; German Center for Diabetes Research (DZD), Neuherberg, Germany. hrabe@helmholtz-muenchen.de.; Department of Experimental Genetics, TUM School of Life Science, Technische Universität Munich, Freising, Germany. hrabe@helmholtz-muenchen.de.
Publikováno v:
Nature cardiovascular research [Nat Cardiovasc Res] 2022 Feb; Vol. 1 (2), pp. 157-173. Date of Electronic Publication: 2022 Feb 17.