p53 promotes revival stem cells in the regenerating intestine after severe radiation injury.

Autor: Morral C; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Ayyaz A; Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.; Department of Biological Sciences, University of Calgary, Calgary, AB, Canada., Kuo HC; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Fink M; Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Verginadis II; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Daniel AR; Department of Radiation Oncology, Duke University, Durham, NC, USA., Burner DN; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Driver LM; Department of Radiation Oncology, Duke University, Durham, NC, USA.; Department of Pathology, Duke University, Durham, NC, USA., Satow S; Department of Radiation Oncology, Duke University, Durham, NC, USA., Hasapis S; Department of Radiation Oncology, Duke University, Durham, NC, USA., Ghinnagow R; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Luo L; Department of Radiation Oncology, Duke University, Durham, NC, USA., Ma Y; Department of Radiation Oncology, Duke University, Durham, NC, USA., Attardi LD; Departments of Radiation Oncology and Genetics, Stanford University, Palo Alto, CA, USA., Koumenis C; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Minn AJ; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Parker Institute for Cancer Immunotherapy, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Mark Foundation Center for Immunotherapy, Immune Signaling, and Radiation, University of Pennsylvania, Philadelphia, PA, USA., Wrana JL; Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada. wrana@lunenfeld.ca.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. wrana@lunenfeld.ca., Lee CL; Department of Radiation Oncology, Duke University, Durham, NC, USA. chang-lung.lee@duke.edu.; Department of Pathology, Duke University, Durham, NC, USA. chang-lung.lee@duke.edu., Kirsch DG; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA. david.kirsch@uhn.ca.; Department of Radiation Oncology, Duke University, Durham, NC, USA. david.kirsch@uhn.ca.; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. david.kirsch@uhn.ca.; Departments of Radiation Oncology and Medical Biophysics, University of Toronto, Toronto, ON, Canada. david.kirsch@uhn.ca.

Publikováno v: Nature communications [Nat Commun] 2024 Apr 08; Vol. 15 (1), pp. 3018. Date of Electronic Publication: 2024 Apr 08.

p53 promotes revival stem cells in the regenerating intestine after severe radiation injury.

Autor: Morral C, Ayyaz A, Kuo HC, Fink M, Verginadis I, Daniel AR, Burner DN, Driver LM, Satow S, Hasapis S, Ghinnagow R, Luo L, Ma Y, Attardi LD, Koumenis C, Minn AJ, Wrana JL, Lee CL, Kirsch DG

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Apr 28. Date of Electronic Publication: 2023 Apr 28.

Whole-Exome Sequencing of Radiation-Induced Thymic Lymphoma in Mouse Models Identifies Notch1 Activation as a Driver of p53 Wild-Type Lymphoma.

Autor: Lee CL; Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina. david.kirsch@duke.edu chang-lung.lee@duke.edu.; Department of Pathology, Duke University Medical Center, Durham, North Carolina.; Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina., Brock KD; Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina., Hasapis S; Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina., Zhang D; Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina., Sibley AB; Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina., Qin X; Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina., Gresham JS; Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina., Caraballo I; Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina., Luo L; Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina., Daniel AR; Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina., Hilton MJ; Department of Orthopedic Surgery, Duke University Medical Center, Durham, North Carolina., Owzar K; Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina.; Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, North Carolina., Kirsch DG; Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina. david.kirsch@duke.edu chang-lung.lee@duke.edu.; Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina.; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina.

Publikováno v: Cancer research [Cancer Res] 2021 Jul 15; Vol. 81 (14), pp. 3777-3790. Date of Electronic Publication: 2021 May 25.

Regulation of the Intestinal Stem Cell Pool and Proliferation in Drosophila.

Autor: Trubin, Simona¹ (AUTHOR), Patel, Dhruv B.¹ (AUTHOR), Tian, Aiguo^1,2 (AUTHOR) atian@tulane.edu

Publikováno v: Cells (2073-4409). Nov2024, Vol. 13 Issue 22, p1856. 18p.

Epithelial Regeneration After Doxorubicin Arises Primarily From Early Progeny of Active Intestinal Stem Cells.

Autor: Sheahan BJ; Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina., Freeman AN; Department of Biological Sciences, College of Sciences, North Carolina State University, Raleigh, North Carolina., Keeley TM; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan., Samuelson LC; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan., Roper J; Division of Gastroenterology, Department of Medicine, Duke University, Durham, North Carolina; Department of Pharmacology and Cancer Biology, Duke University, Durham, North Carolina., Hasapis S; Department of Radiation Oncology, Duke University, Durham, North Carolina., Lee CL; Department of Radiation Oncology, Duke University, Durham, North Carolina; Department of Pathology, Duke University, Durham, North Carolina., Dekaney CM; Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina. Electronic address: cmdekane@ncsu.edu.

Publikováno v: Cellular and molecular gastroenterology and hepatology [Cell Mol Gastroenterol Hepatol] 2021; Vol. 12 (1), pp. 119-140. Date of Electronic Publication: 2021 Feb 08.