Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Hasanga D Manikpurage"'
Autor:
Véronique Boumtje, Hasanga D. Manikpurage, Zhonglin Li, Nathalie Gaudreault, Victoria Saavedra Armero, Dominique K. Boudreau, Sébastien Renaut, Cyndi Henry, Christine Racine, Aida Eslami, Stéphanie Bougeard, Evelyne Vigneau, Mathieu Morissette, Benoit J. Arsenault, Catherine Labbé, Anne-Sophie Laliberté, Simon Martel, François Maltais, Christian Couture, Patrice Desmeules, Patrick Mathieu, Sébastien Thériault, Philippe Joubert, Yohan Bossé
Publikováno v:
EBioMedicine, Vol 106, Iss , Pp 105234- (2024)
Summary: Background: The most near-term clinical application of genome-wide association studies in lung cancer is a polygenic risk score (PRS). Methods: A case-control dataset was generated consisting of 4002 lung cancer cases from the LORD project a
Externí odkaz:
https://doaj.org/article/bb4fffdb85804cb38b27e61371ec15a2
Autor:
Sébastien Thériault, Zhonglin Li, Erik Abner, Jian’an Luan, Hasanga D. Manikpurage, Ursula Houessou, Pardis Zamani, Mewen Briend, Estonian Biobank Research Team, Dominique K. Boudreau, Nathalie Gaudreault, Lily Frenette, Déborah Argaud, Manel Dahmene, François Dagenais, Marie-Annick Clavel, Philippe Pibarot, Benoit J. Arsenault, S. Matthijs Boekholdt, Nicholas J. Wareham, Tõnu Esko, Patrick Mathieu, Yohan Bossé
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract There is currently no medical therapy to prevent calcific aortic valve stenosis (CAVS). Multi-omics approaches could lead to the identification of novel molecular targets. Here, we perform a genome-wide association study (GWAS) meta-analysis
Externí odkaz:
https://doaj.org/article/5660b9921e9f456da6aee9115481bb7c
Autor:
Eloi Gagnon, Patricia L. Mitchell, Hasanga D. Manikpurage, Erik Abner, Nele Taba, Tõnu Esko, Nooshin Ghodsian, Sébastien Thériault, Patrick Mathieu, Benoit J. Arsenault
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-14 (2023)
Abstract Features of the gut microbiota have been associated with several chronic diseases and longevity in preclinical models as well as in observational studies. Whether these relations underlie causal effects in humans remains to be established. W
Externí odkaz:
https://doaj.org/article/b9e79a829e284631b9b9c8a97926c594
Autor:
Eloi Gagnon, William Pelletier, Émilie Gobeil, Jérôme Bourgault, Hasanga D. Manikpurage, Ina Maltais-Payette, Erik Abner, Nele Taba, Tõnu Esko, Patricia L. Mitchell, Nooshin Ghodsian, Jean-Pierre Després, Marie-Claude Vohl, André Tchernof, Sébastien Thériault, Benoit J. Arsenault
Publikováno v:
Communications Medicine, Vol 2, Iss 1, Pp 1-9 (2022)
Gagnon et al. perform a Mendelian randomization study to investigate whether excess liver fat underpins adiposity’s effect on cardiometabolic disease risk. They show that abdominal adiposity strongly increases disease risk independently of liver fa
Externí odkaz:
https://doaj.org/article/1e515edb333a4daa9d17086f57f33806
Autor:
Audrey Paulin, Hasanga D. Manikpurage, Jean‐Pierre Després, Sébastien Thériault, Benoit J. Arsenault
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 13 (2023)
Background The impact of an elevated body mass index (BMI) on atherosclerotic cardiovascular disease (ASCVD) risk in individuals who are metabolically healthy is debated. We investigated the respective contributions of BMI as well as lifestyle and ca
Externí odkaz:
https://doaj.org/article/244142ec0f2243559a0c24d27576972e
Autor:
Eloi Gagnon, Hasanga D. Manikpurage, Patricia L. Mitchell, Arnaud Girard, Émilie Gobeil, Jérôme Bourgault, Frédéric Bégin, André Marette, Sébastien Thériault, Benoit J. Arsenault
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107127- (2023)
Summary: Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent disease with no specific drug therapy. High-throughput metabolomics present an unprecedented opportunity to identify biomarkers and potentially causal risk factors for NAFLD. He
Externí odkaz:
https://doaj.org/article/863b56e453914201bf167c51034484e4
Autor:
Nooshin Ghodsian, Erik Abner, Connor A. Emdin, Émilie Gobeil, Nele Taba, Mary E. Haas, Nicolas Perrot, Hasanga D. Manikpurage, Éloi Gagnon, Jérôme Bourgault, Alexis St-Amand, Christian Couture, Patricia L. Mitchell, Yohan Bossé, Patrick Mathieu, Marie-Claude Vohl, André Tchernof, Sébastien Thériault, Amit V. Khera, Tõnu Esko, Benoit J. Arsenault
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 11, Pp 100437- (2021)
Summary: Non-alcoholic fatty liver disease (NAFLD) is a complex disease linked to several chronic diseases. We aimed at identifying genetic variants associated with NAFLD and evaluating their functional consequences. We performed a genome-wide meta-a
Externí odkaz:
https://doaj.org/article/19e306941a06424da1e769a90f8e839d
Autor:
Émilie Gobeil, Ina Maltais-Payette, Nele Taba, Francis Brière, Nooshin Ghodsian, Erik Abner, Jérôme Bourgault, Eloi Gagnon, Hasanga D. Manikpurage, Christian Couture, Patricia L. Mitchell, Patrick Mathieu, François Julien, Jacques Corbeil, Marie-Claude Vohl, Sébastien Thériault, Tõnu Esko, André Tchernof, Benoit J. Arsenault
Publikováno v:
Metabolites, Vol 12, Iss 5, p 440 (2022)
Non-alcoholic fatty liver disease (NAFLD) is a complex disease associated with premature mortality. Its diagnosis is challenging, and the identification of biomarkers causally influenced by NAFLD may be clinically useful. We aimed at identifying bloo
Externí odkaz:
https://doaj.org/article/1a796f052f7a4aaeaffc4dd6decd1d67
Autor:
Arnaud Girard, Emilie Gaillard, Rishi Puri, Romain Capoulade, Kwan L Chan, Audrey Paulin, Hasanga D Manikpurage, Jean Dumesnil, James W Tam, Koon K Teo, Christian Couture, Nicholas J Wareham, Marie-Annick Clavel, Erik S G Stroes, Patrick Mathieu, Sébastien Thériault, Sotirios Tsimikas, Philippe Pibarot, S Matthijs Boekholdt, Benoit J Arsenault
Publikováno v:
European heart journal open, vol 3, iss 2
Aims Elevated lipoprotein(a) [Lp(a)] levels are associated with the risk of coronary artery disease (CAD) and calcific aortic valve stenosis (CAVS). Observational studies revealed that Lp(a) and C-reactive protein (CRP) levels, a biomarker of systemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03a19ea67877056ba055d6f7c5e539fb
https://www.repository.cam.ac.uk/handle/1810/349234
https://www.repository.cam.ac.uk/handle/1810/349234
Autor:
Amel, Bouhadoun, Hasanga D, Manikpurage, Catherine, Deschildre, Sara, Zalghout, Marc, Dubourdeau, Valérie, Urbach, Benoît, Ho-Tin-Noe, Lydia, Deschamps, Jean-Baptiste, Michel, Dan, Longrois, Xavier, Norel
Publikováno v:
Prostaglandinsother lipid mediators. 165
In patients with coronary artery disease (CAD), plasma levels of pro-inflammatory lipid mediators such as PGE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d3fd9da467ac1a1aacf036459b332575
https://pubmed.ncbi.nlm.nih.gov/36528331
https://pubmed.ncbi.nlm.nih.gov/36528331