Perceived barriers to pediatrician and family practitioner participation in pediatric clinical trials: Findings from the Clinical Trials Transformation Initiative

Autor: Rachel G. Greenberg, Amy Corneli, John Bradley, John Farley, Hasan S. Jafri, Li Lin, Sumathi Nambiar, Gary J. Noel, Chris Wheeler, Rosemary Tiernan, P. Brian Smith, Jamie Roberts, Daniel K. Benjamin, Jr.

Publikováno v: Contemporary Clinical Trials Communications, Vol 9, Iss C, Pp 7-12 (2018)

Despite legislation to stimulate pediatric drug development through clinical trials, enrolling children in trials continues to be challenging. Non-investigator (those who have never served as a clinical trial investigator) providers are essential to

Externí odkaz: https://doaj.org/article/85599ffdeb79468c83dab72b8ba406ac

Risk prediction for Staphylococcus aureus surgical site infection following cardiothoracic surgery; A secondary analysis of the V710-P003 trial.

Autor: Fleur P Paling, Karina Olsen, Kristin Ohneberg, Martin Wolkewitz, Vance G Fowler, Mark J DiNubile, Hasan S Jafri, Frangiscos Sifakis, Marc J M Bonten, Stephan J Harbarth, Jan A J W Kluytmans

Publikováno v: PLoS ONE, Vol 13, Iss 3, p e0193445 (2018)

Identifying patients undergoing cardiothoracic surgery at high risk of Staphylococcus aureus surgical site infection (SSI) is a prerequisite for implementing effective preventive interventions. The objective of this study was to develop a risk predic

Externí odkaz: https://doaj.org/article/c85c0c00de904f37a8bfbecb516dc0f6

Efficacy and safety of suvratoxumab for prevention of Staphylococcus aureus ventilator-associated pneumonia (SAATELLITE)

Autor: Saad Nseir, Thierry Boulain, Georgios Baltopoulos, Julie Vignaud, Adel Maamar, Kathryn Shoemaker, Bertrand Souweine, Frédéric Dailler, Pierre-François Laterre, Pedro Moura, Jacques Creteur, Lucia Viña Soria, Terramika Bellamy, Andreas Meier-Hellmann, Alain Mercat, Matthias Gründling, Johann Motsch, Djillali Annane, Paula Ramirez, Christophe Guitton, Antonio Torres Marti, Marco Maggiorini, Tomas Suchy, Alain Lepape, Petr Svoboda, Michal Hanauer, Jan Pachl, Martin Balik, Jérôme Pugin, Jean-Christophe Navellou, Miguel Sánchez-García, Laurent Argaud, Arnaud Desachy, Vasilios Koulouras, Jean-Luc Pagani, Raúl De Pablo Sanchez, Pierre-François Dequin, Carole Schwebel, Ana Catalina Hernandez Padilla, Georgios Filntisis, Patrick Biston, Tomas Vymazal, Juan Carlos Valia, Vadryn Pierre, Frank E. J. Coenjaerts, Frank Wappler, Vladimir Sramek, Fabienne Tamion, Ildikó Krémer, Hasan S Jafri, Zsuzsa Marjanek, Didier Chochrad, Jose Lorente, Marc Simon, Herbert Spapen, Juan Carlos Montejo González, Omar Ali, Cédric Bretonnière, Maria Consuelo Pintado Delgado, Filip Dubovsky, Leen Timbermont, Apostolos Komnos, Christine Lammens, Pin Ren, Tobias Welte, Spyros Zakynthinos, Olivier Barraud, Tomas Hruby, Alain Dive, Herman Goossens, Alexey Ruzin, Marc J. M. Bonten, Ricard Ferrer Roca, Lorenz Reill, Yves Bouckaert, Epaminondas Zakynthinos, Zoltán Szentkereszty, Oliver A. Cornely, Josep Trenado, Antoine Gros, Marc Bourgeois, Ferhat Meziani, Katrin Schmidt, Bruno François, Philippe Eggimann, Ioanna Soultati, Jean-Marc Tadie, Frank Bloos, Agnes Sarkany, Francis Schneider, Susan Colbert, Maria Deja, Mark T. Esser, Gilles Francony, Caroline Rolfes, Martin Nováček, Ana Loza Vazquez, Yuling Wu, Jean-Yves Lefrant, Dolores Escudero, Jean Chastre, Frédéric Foret, René Robert, Vasileios Bekos, Vincent Huberlant, Ioannis Pnevmatikos

Publikováno v: The lancet infectious diseases
The Lancet. Infectious diseases, Vol. 21, no.9, p. 1313-1323 (2021)

Summary Background Staphylococcus aureus remains a common cause of ventilator-associated pneumonia, with little change in incidence over the past 15 years. We aimed to evaluate the efficacy of suvratoxumab, a monoclonal antibody targeting the α toxi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b15ccdd46639f0fdf9639d0d5e7f317
https://biblio.vub.ac.be/vubir/(5cde9a53-ceeb-4295-8185-cc8c8f24c7f3).html

1486. Phylogenetic and alpha toxin variant analyses of Staphylococcus aureus strains isolated from patients during the SAATELLITE study

Autor: Hasan S Jafri, Surbhi Malhotra-Kumar, Herman Goossens, Alexey Ruzin, Kathryn Shoemaker, Bruno François, Leen Timbermont, David E. Tabor, Jasmine Coppens, Christine Lammens, Andrey Tovchigrechko, Pin Ren, B.B. Xavier, Bret R. Sellman, Mark T. Esser, Christine Tkaczyk, Michael McCarthy

Publikováno v: Open Forum Infectious Diseases

Background Suvratoxumab is a human monoclonal antibody that neutralizes S. aureus (SA) alpha toxin (AT). SAATELLITE, a phase 2 study of the safety and efficacy of suvratoxumab for reducing the incidence of SA pneumonia (NCT02296320), was conducted wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a2465cde51bc4ca8803ac764ae18eaf
http://europepmc.org/articles/PMC7777803

The SAATELLITE and EVADE Clinical Studies Within the COMBACTE Consortium: A Public–Private Collaborative Effort in Designing and Performing Clinical Trials for Novel Antibacterial Drugs to Prevent Nosocomial Pneumonia: Table 1

Autor: Bruno François, Marc J. M. Bonten, Philippe Eggiman, Pierre-François Laterre, Miguel Angel Gomez Sanchez, Antoni Torres, Herman Goosens, Brian Bishop, Hasan S. Jafri, Jean Chastre, Mark T. Esser

Publikováno v: Clinical Infectious Diseases. 63:S46-S51

The Innovative Medicines Initiative-funded COMBACTE consortium fosters academic-industry partnership in pioneering studies to combat serious bacterial infections. We describe how this partnership is advancing the development of 2 monoclonal antibodie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bff9b6828231628932eb3b7178ad6a8f
https://doi.org/10.1093/cid/ciw245