Zobrazeno 1 - 10
of 174
pro vyhledávání: '"Hasan Korkaya"'
Autor:
Chaitanya A. Patwardhan, Vamsi Krishna Kommalapati, Taoufik Llbiyi, Digvijay Singh, Eyad Alfa, Anatolij Horuzsko, Hasan Korkaya, Siva Panda, Christopher A. Reilly, Vladimir Popik, Ahmed Chadli
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Heat shock protein 90 (Hsp90) and its co-chaperones promote cancer, and targeting Hsp90 holds promise for cancer treatment. Most of the efforts to harness this potential have focused on targeting the Hsp90 N-terminus ATP binding site. Althou
Externí odkaz:
https://doaj.org/article/9e5b533d54cf49d1844e10517fac6d50
Autor:
Nada H. Eisa, Vincent M. Crowley, Asif Elahi, Vamsi Krishna Kommalapati, Michael A. Serwetnyk, Taoufik Llbiyi, Sumin Lu, Kashish Kainth, Yasmeen Jilani, Daniela Marasco, Abdeljabar El Andaloussi, Sukyeong Lee, Francis T.F. Tsai, Paulo C. Rodriguez, David Munn, Esteban Celis, Hasan Korkaya, Abdessamad Debbab, Brian Blagg, Ahmed Chadli
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108308- (2023)
Summary: Low response rates and immune-related adverse events limit the remarkable impact of cancer immunotherapy. To improve clinical outcomes, preclinical studies have shown that combining immunotherapies with N-terminal Hsp90 inhibitors resulted i
Externí odkaz:
https://doaj.org/article/f4ba062b1eb84919b99e30fb877c3d61
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/c64a1bd5ed074ad7ad926bb9121cd138
Autor:
Raziye Piranlioglu, EunMi Lee, Maria Ouzounova, Roni J. Bollag, Alicia H. Vinyard, Ali S. Arbab, Daniela Marasco, Mustafa Guzel, John K. Cowell, Muthushamy Thangaraju, Ahmed Chadli, Khaled A. Hassan, Max S. Wicha, Esteban Celis, Hasan Korkaya
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Dissemination of tumor cells from the primary site is an early event. Here, the authors show that the early disseminated tumor cells are actively cleared by the host cytotoxic T lymphocytes induced by the primary tumor and that infiltration of granul
Externí odkaz:
https://doaj.org/article/ab8309125be1466c9f20adaacc94d582
Autor:
Hasan Korkaya, Sandra Orsulic
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Externí odkaz:
https://doaj.org/article/be328100218d4a3c823b75613145d7ae
Autor:
Xiaolin Yu, Sharad Ghamande, Haitao Liu, Lu Xue, Shuhua Zhao, Wenxi Tan, Lijing Zhao, Shou-Ching Tang, Daqing Wu, Hasan Korkaya, Nita J. Maihle, Hong Yan Liu
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 10, Iss , Pp 317-330 (2018)
HER family members are interdependent and functionally compensatory. Simultaneously targeting EGFR/HER2/HER3 by antibody combinations has demonstrated superior treatment efficacy over targeting one HER receptor. However, antibody combinations have th
Externí odkaz:
https://doaj.org/article/59b967c81b704f36b46f263e8b73b15d
Autor:
Maria Ouzounova, Eunmi Lee, Raziye Piranlioglu, Abdeljabar El Andaloussi, Ravindra Kolhe, Mehmet F. Demirci, Daniela Marasco, Iskander Asm, Ahmed Chadli, Khaled A. Hassan, Muthusamy Thangaraju, Gang Zhou, Ali S. Arbab, John K. Cowell, Hasan Korkaya
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Myeloid-derived suppressive cells (MDSCs) promote metastasis. Here, the authors show that the monocytic MDSCs subset promotes epithelial to mesenchymal transition at the primary site while the granulocytic subset promotes the reverse transition at th
Externí odkaz:
https://doaj.org/article/fd3befe0433a4fdaa9773cbb10f54358
Autor:
Evrin Gunebakan, Esra Yalcin, Esra Cikler Dulger, Ahmet Yigitbasi, Nilay Ates, Aysun Caglayan, Mustafa C. Beker, Kazim Sahin, Hasan Korkaya, Ertugrul Kilic
Publikováno v:
Biomedicines, Vol 8, Iss 2, p 23 (2020)
Cisplatin (CP) is one of the most preferred platinum-containing antineoplastic drugs. However, even in nontoxic plasma concentrations, it may cause kidney injury. To be able to increase its effective pharmacological dose, its side effects need to be
Externí odkaz:
https://doaj.org/article/ccbe71fbf0bc4b2db1e7ed9d28157792
Autor:
Thaiz F Borin, Adarsh Shankar, Kartik Angara, Mohammad H Rashid, Meenu Jain, Asm Iskander, Roxan Ara, Iryna Lebedyeva, Hasan Korkaya, Bhagelu R Achyut, Ali S Arbab
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0178830 (2017)
Distant metastasis is the primary cause of death in the majority of the cancer types. Recently, much importance has been given to tumor microenvironment (TME) in the development of invasive malignant tumors, as well as the metastasis potential. The a
Externí odkaz:
https://doaj.org/article/e56cd515e4124672bc67342fa6a0f07b
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 9, p 2357 (2019)
It is now widely believed that mammary epithelial cell plasticity, an important physiological process during the stages of mammary gland development, is exploited by the malignant cells for their successful disease progression. Normal mammary epithel
Externí odkaz:
https://doaj.org/article/bbf017f3e0414579b8239f3db9407add