Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Hasan E. Zumrut"'
Autor:
Hasan E. Zumrut, Sana Batool, Kimon V. Argyropoulos, Nicole Williams, Roksana Azad, Prabodhika R. Mallikaratchy
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 17, Iss , Pp 150-163 (2019)
To discover DNA ligands against a predetermined receptor protein complex, we introduce a comprehensive version of ligand-guided selection (LIGS). LIGS is, itself, a variant of systematic evolution of ligands by exponential enrichment (SELEX). Herein,
Externí odkaz:
https://doaj.org/article/4a6ad79321ff420980cba359fce9ef83
Publikováno v:
Biology Open, Vol 2, Iss 5, Pp 505-514 (2013)
Summary Vertebrate muscle development occurs through sequential differentiation of cells residing in somitic mesoderm – a process that is largely governed by transcriptional regulators. Our recent spatiotemporal microarray study in zebrafish has id
Externí odkaz:
https://doaj.org/article/f369b7e83d6545b5a0e95da604206569
Autor:
Nicole B. Williams, Sana Batool, Hasan E. Zumrut, Rutika Patel, German Sosa, Mohammad Jamal, Prabodhika Mallikaratchy
Publikováno v:
Biochemistry. 61:1600-1613
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62361d18bc8d96faff9885a590fd6324
https://doi.org/10.1021/acs.biochem.2c00105
https://doi.org/10.1021/acs.biochem.2c00105
Autor:
Nicole B, Williams, Sana, Batool, Hasan E, Zumrut, Rutika, Patel, German, Sosa, Mohammad, Jamal, Prabodhika, Mallikaratchy
Publikováno v:
Biochemistry. 61(15)
Aptamer ligand discovery against multiple molecules expressed on whole cells is an essential component in molecular tool development. However, owing to their intrinsic structural characteristics, cell-surface receptors have proven to be challenging t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7e40a5fd2621088f1c2cda9e7580e46b
https://pubmed.ncbi.nlm.nih.gov/35829681
https://pubmed.ncbi.nlm.nih.gov/35829681
Autor:
Roksana Azad, Sana Batool, Prabodhika Mallikaratchy, Kimon V. Argyropoulos, Nicole Williams, Hasan E. Zumrut
Publikováno v:
Molecular Therapy. Nucleic Acids
Molecular Therapy: Nucleic Acids, Vol 17, Iss, Pp 150-163 (2019)
Molecular Therapy: Nucleic Acids, Vol 17, Iss, Pp 150-163 (2019)
To discover DNA ligands against a predetermined receptor protein complex, we introduce a comprehensive version of ligand-guided selection (LIGS). LIGS is, itself, a variant of systematic evolution of ligands by exponential enrichment (SELEX). Herein,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffb10a3385dbe69dc1439445a9d792ae
https://doi.org/10.1016/j.omtn.2019.05.015
https://doi.org/10.1016/j.omtn.2019.05.015
Autor:
Chiara Platella, Sana Batool, Prabodhika Mallikaratchy, Daniela Montesarchio, John Bradshaw, Hasan E. Zumrut, Federica Moccia, Domenica Musumeci
Publikováno v:
Int J Biol Macromol
Exploiting a variant of SELEX called “Ligand-Guided Selection” (LI-GS), we recently identified two novel truncated G-rich aptamers, called R1.2 and R1.3, specific for membrane-bound IgM (mIgM), the hallmark of B cells. Herein, the conformational
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a8d36617eaba88dff38e5fd3935019
https://doi.org/10.1016/j.ijbiomac.2019.04.141
https://doi.org/10.1016/j.ijbiomac.2019.04.141
Autor:
Kimon V. Argyropoulos, Rigzin Dekhang, Precious Okeoma, Sana Batool, Roksana Azad, Sanam Bhandari, Prabodhika Mallikaratchy, Hasan E. Zumrut
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1863:232-240
Nucleic Acid Aptamers (NAAs) are a class of synthetic DNA or RNA molecules that bind specifically to their target. We recently introduced an aptamer termed R1.2 against membrane Immunoglobulin M (mIgM) expressing B-cell neoplasms using Ligand Guided
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7a2674b8d2f6a64ccb5c01ead5d3dab
https://doi.org/10.1016/j.bbagen.2018.10.006
https://doi.org/10.1016/j.bbagen.2018.10.006
Autor:
Joekeem Arizala, Nicole Williams, Sana Batool, Prabodhika Mallikaratchy, Hasan E. Zumrut, Zunyi Yang, Steven A. Benner
Publikováno v:
Biochemistry
Here we are reporting, for the first time, a ligand-guided selection (LIGS) experiment using an artificially expanded genetic information system (AEGIS) to successfully identify an AEGIS–DNA aptamer against T cell receptor-CD3ε expressed on Jurkat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4be2f8a0210b37ebb3db6884b86fb66a
https://pubmed.ncbi.nlm.nih.gov/31880917
https://pubmed.ncbi.nlm.nih.gov/31880917
Autor:
Hasan E. Zumrut, Sanam Bhandari, Sana Batool, Nabeela A. Van, Prabodhika Mallikaratchy, Shanell George
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1861:1825-1832
Aptamers are synthetic, short nucleic acid molecules capable of specific target recognition. Aptamers are selected using a screening method termed Systematic Evolution of Ligands by Exponential enrichment (SELEX). We recently have introduced a varian
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ace674b9119b9b958d71309d2c4a7434
https://doi.org/10.1016/j.bbagen.2017.03.020
https://doi.org/10.1016/j.bbagen.2017.03.020
Publikováno v:
Nucleic Acid Therapeutics. 26:190-198
We report on a new strategy for identifying highly specific aptamers against a predetermined epitope of a target. Termed “ligand-guided selection” (LIGS), this method uniquely exploits the selection step, the core of SELEX (Systematic Evolution E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f7b96ff30bad484a9e5ff4f37a3b47c
https://doi.org/10.1089/nat.2016.0611
https://doi.org/10.1089/nat.2016.0611