Engineering human skin model innervated with itch sensory neuron‐like cells differentiated from induced pluripotent stem cells

Autor: Zongyou Guo, Chi‐Kun Tong, Joanna Jacków, Yanne S. Doucet, Hasan E. Abaci, Wangyong Zeng, Corey Hansen, Ryota Hayashi, Dominick DeLorenzo, Avina Rami, Alberto Pappalardo, Ellen A. Lumpkin, Angela M. Christiano

Publikováno v: Bioengineering & Translational Medicine, Vol 7, Iss 1, Pp n/a-n/a (2022)

Abstract Atopic dermatitis (AD), driven by interleukins (IL‐4/IL‐13), is a chronic inflammatory skin disease characterized by intensive pruritus. However, it is unclear how immune signaling and sensory response pathways cross talk with each other

Externí odkaz: https://doaj.org/article/e02dbcb9a03e4f028a42af44b195894e

Quantitative Evaluation of Human Umbilical Vein and Induced Pluripotent Stem Cell-Derived Endothelial Cells as an Alternative Cell Source to Skin-Specific Endothelial Cells in Engineered Skin Grafts

Autor: David Alvarez Cespedes, Lauren Herron, Hasan E. Abaci, Alberto Pappalardo

Publikováno v: Adv Wound Care (New Rochelle)

Objective: We compared the capability of human umbilical vein endothelial cells (HUVECs), induced pluripotent stem cell (iPSC)-derived endothelial cells (iECs), and human dermal blood endothelial cells (HDBECs) to effectively vascularize engineered h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::387c56e3e60501194c907a6b3f380410
https://doi.org/10.1089/wound.2020.1163

CRISPR/Cas9-based targeted genome editing for correction of recessive dystrophic epidermolysis bullosa using iPS cells

Autor: D. Delorenzo, Angela M. Christiano, Satoru Shinkuma, Hasan E. Abaci, Corey Hansen, Joanna Jacków, Zongyou Guo, Julio C. Salas-Alanis, Y. Doucet, R. Hayashi, Y. Kabata, J. Shin

Publikováno v: Proc Natl Acad Sci U S A

Recessive dystrophic epidermolysis bullosa (RDEB) is a severe inherited skin disorder caused by mutations in the COL7A1 gene encoding type VII collagen (C7). The spectrum of severity depends on the type of mutation in the COL7A1 gene. C7 is the major

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32757489247d1c5a46361a6cb84c6fcd
https://doi.org/10.1073/pnas.1907081116

Tissue engineering of human hair follicles using a biomimetic developmental approach

Autor: Angela M. Christiano, Colin A.B. Jahoda, Hasan E. Abaci, Joanna Jacków, A. Coffman, Z. Guo, Etienne C. E. Wang, J.C. Chen, J. Shin, Y. Doucet

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Abaci, H E, Coffman, A, Doucet, Y, Chen, J, Jacków, J, Wang, E, Guo, Z, Shin, J U, Jahoda, C A & Christiano, A M 2018, ' Tissue engineering of human hair follicles using a biomimetic developmental approach ', Nature Communications, vol. 9, no. 1, 5301 . https://doi.org/10.1038/s41467-018-07579-y
Nature Communications
Nature communications, 2018, Vol.9(1), pp.5301 [Peer Reviewed Journal]

Human skin constructs (HSCs) have the potential to provide an effective therapy for patients with significant skin injuries and to enable human-relevant drug screening for skin diseases; however, the incorporation of engineered skin appendages, such

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f5ae174b5d2b490d96cbfc1752dc0f7
http://link.springer.com/article/10.1038/s41467-018-07579-y

Production-scale fibronectin nanofibers promote wound closure and tissue repair in a dermal mouse model

Autor: Jeffrey W. Ruberti, Sean P. Sheehy, Hasan E. Abaci, Jeffrey A. Paten, Leila F. Deravi, Simon P. Hoerstrup, Benjamin D. Pope, Karl Gledhill, Andrew K. Capulli, Kevin Kit Parker, Adrian T. Buganza, Y. Doucet, Patrick H. Campbell, Angela M. Christiano, Christophe O. Chantre, Stephanie Dauth, Seungkuk Ahn, Holly M. Golecki

Publikováno v: Biomaterials. 166:96-108

Wounds in the fetus can heal without scarring. Consequently, biomaterials that attempt to recapitulate the biophysical and biochemical properties of fetal skin have emerged as promising pro-regenerative strategies. The extracellular matrix (ECM) prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17b797cf48964f5ba970c0321895dd2d
https://doi.org/10.1016/j.biomaterials.2018.03.006