Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Hasan A. Irier"'
Autor:
R. Craig Street, Bing Yao, Hasan A. Irier, Ronak Dave, Timothy Hayden Davis, Li Lin, Peng Jin, Ying Cheng, Catherine W. Cai
Publikováno v:
Genomics. 104(5):376-382
Gene–environment interactions mediated at the epigenetic level may provide an initial step in delivering an appropriate response to environmental changes. 5-Hydroxymethylcytosine (5hmC), a DNA base derived from 5-methylcytosine (5mC), accounts for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b76d3b0a54d9c06bb374004c15dbf5d8
Publikováno v:
Journal of Neurochemistry. 109:584-594
The glutamate receptor 2 (GluR2) subunit determines many of the functional properties of the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate subtype of glutamate receptor. The roles of untranslated regions (UTRs) in mRNA stability, transport, or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d2b7e51687a11c4a4db1e2625cf3966
https://doi.org/10.1111/j.1471-4159.2009.05992.x
https://doi.org/10.1111/j.1471-4159.2009.05992.x
Autor:
Scott J. Myers, Phuong Le, Raymond Dingledine, Dennis C. Liotta, Hasan A. Irier, Adam French, Matthew T. Geballe, Yesim Altas Tahirovic, Robert Kotloski, Ewa Gruszecka-Kowalik, Woo-Baeg Choi, Hongjie Yuan, Lawrence J. Wilson, Stephen F. Traynelis, Polina Lyuboslavsky, James O. McNamara, James P. Snyder, Keith W Easterling
Publikováno v:
Journal of Medicinal Chemistry. 51:5506-5521
Enantiomeric propanolamines have been identified as a new class of NR2B-selective NMDA receptor antagonists. The most effective agents are biaryl structures, synthesized in six steps with overall yields ranging from 11-64%. The compounds are potent a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::873377656192885b3c6bec2d946da06f
https://doi.org/10.1021/jm8002153
https://doi.org/10.1021/jm8002153
Autor:
Anup K. Upadhyay, Chun-Xiao Song, Qiang Chang, Aparna Vasanthakumar, Hao Wu, Xuekun Li, Marla Gearing, Allan I. Levey, Qing Dai, Keith E. Szulwach, Xiaodong Cheng, Chuan He, Peng Jin, Lucy A. Godley, Hasan A. Irier, Yujing Li
Publikováno v:
Nature neuroscience. 14(12)
DNA methylation dynamics influence brain function and are altered in neurological disorders. 5-hydroxymethylcytosine (5-hmC), a DNA base that is derived from 5-methylcytosine, accounts for ~40% of modified cytosine in the brain and has been implicate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf9d9ef0eabc14c786efac9b66671e27
https://pubmed.ncbi.nlm.nih.gov/22119946
https://pubmed.ncbi.nlm.nih.gov/22119946
Autor:
Mingjing Xia, Baoji Xu, Yue Feng, Hasan A. Irier, James Q. Zheng, Jiaping Gu, Donghua Tian, Brita Fritsch, Bai Lu, Anthony G. Lau, Guanglu Liu, Li Ku, Raymond Dingledine
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 107(36)
Expression of the brain-derived neurotrophic factor (BDNF) is under tight regulation to accommodate its intricate roles in controlling brain function. Transcription of BDNF initiates from multiple promoters in response to distinct stimulation cues. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8e85fc77fb5323b53965637227a015d
https://pubmed.ncbi.nlm.nih.gov/20733072
https://pubmed.ncbi.nlm.nih.gov/20733072
Publikováno v:
Molecular pharmacology. 76(6)
Four major glutamate receptor 2 (GluR2) transcripts differing in size (approximately 4 and approximately 6 kilobases) due to alternative 3' untranslated regions (UTRs), and also containing alternative 5'UTRs, exist in the brain. Both the long 5'UTR a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cddf96a136e917015c0ccf40d389f5a3
https://pubmed.ncbi.nlm.nih.gov/19794129
https://pubmed.ncbi.nlm.nih.gov/19794129
Publikováno v:
Experimental neurology. 201(2)
Astrocytes are relatively resistant to injury compared to neurons and oligodendrocytes. Here, we report transient region-specific loss of astrocytes in mice early after pilocarpine-induced status epilepticus (SE). In the dentate hilus, immunoreactivi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af023158e017d03f3b9978b606fd06d5
https://pubmed.ncbi.nlm.nih.gov/16793040
https://pubmed.ncbi.nlm.nih.gov/16793040
Autor:
Hasan A. Irier, Peng Jin
Publikováno v:
DNA and Cell Biology. 31:S-42
Gene expression is modulated by epigenetic factors that come in varying forms, such as DNA methylation, histone modifications, microRNAs, and long noncoding RNAs. Recent studies reveal that these epigenetic marks are important regulatory factors in b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b1474be294e7ea6279da01707584d77
https://doi.org/10.1089/dna.2011.1565
https://doi.org/10.1089/dna.2011.1565