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pro vyhledávání: '"Hasan, Rajabi"'
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Autor:
Yota Yasumizu, Hasan Rajabi, Caining Jin, Tsuyoshi Hata, Sean Pitroda, Mark D. Long, Masayuki Hagiwara, Wei Li, Qiang Hu, Song Liu, Nami Yamashita, Atsushi Fushimi, Ling Kui, Mehmet Samur, Masaaki Yamamoto, Yan Zhang, Ning Zhang, Deli Hong, Takahiro Maeda, Takeo Kosaka, Kwok K. Wong, Mototsugu Oya, Donald Kufe
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
MUC1-C is overexpressed in castration-resistant prostate cancer and neuroendocrine prostate cancer. Here, the authors show that MUC1-C drives lineage plasticity through MYC and BRN2, inducing neuroendocrine features and stemness in prostate cancer.
Externí odkaz:
https://doaj.org/article/122d971bc14145f181528834a1ae353b
Autor:
Somayeh Saadat, Mahdi Noureddini, Maryam Mahjoubin-Tehran, Sina Nazemi, Layla Shojaie, Michael Aschner, Behnaz Maleki, Mohammad Abbasi-kolli, Hasan Rajabi Moghadam, Behrang Alani, Hamed Mirzaei
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 7 (2021)
Unintended cardiac fibroblast proliferation in many pathophysiological heart conditions, known as cardiac fibrosis, results in pooling of extracellular matrix (ECM) proteins in the heart muscle. Transforming growth factor β (TGF-β) as a pivotal cyt
Externí odkaz:
https://doaj.org/article/518fd9fb6bda4710bbf170fb24642cf1
Autor:
Hasan Rajabi, Masayuki Hiraki, Ashujit Tagde, Maroof Alam, Audrey Bouillez, Camilla L. Christensen, Mehmet Samur, Kwok-Kin Wong, Donald Kufe
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract The EZH2 histone methyltransferase is a member of the polycomb repressive complex 2 (PRC2) that is highly expressed in diverse human cancers and is associated with a poor prognosis. MUC1-C is an oncoprotein that is similarly overexpressed in
Externí odkaz:
https://doaj.org/article/56075f33571249bb9a4c88495e6d72f5
Supplemental Figure S5AB. A. Lysates from H1299/CshRNA and H1299/MUC1shRNA cells were immunoblotted with the indicated antibodies. B. Representative images of tumorspheres derived from H1299/CshRNA and H1299/MUC1shRNA cells (left). Bar represents 100
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b90b58608c47dcb4352dd9d4d4351b9
https://doi.org/10.1158/1541-7786.22517952.v1
https://doi.org/10.1158/1541-7786.22517952.v1
Autor:
Donald Kufe, Mehmet Samur, Hidekazu Takahashi, Yozo Suzuki, Takahiro Maeda, Masayuki Hiraki, Masaaki Miyo, Deli Hong, Yota Yasumizu, Wei Li, Ling Kui, Yan Zhang, Rehan Ahmad, Caining Jin, Masaaki Yamamoto, Hasan Rajabi, Tsuyoshi Hata
Supplemental Figure S1. Targeting NF-kappaB p65 has little effect on TWIST1 expression; Supplemental Figure S2. Targeting MUC1-C is not associated with regulation of STAT3 mRNA levels; Supplemental Figure S3. Targeting STAT3 genetically or pharmacolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::039b35afddf65838388a9172067cba1a
https://doi.org/10.1158/1535-7163.22504599.v1
https://doi.org/10.1158/1535-7163.22504599.v1
PDF file - 338K, 293T cells were left untreated or treated with G0-203 each day for 4 days. The results (mean plus-minus SD of three replicates) are expressed as the percentage of cell death as determined by trypan blue staining on day 4.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98853ee9ef8cbecb3ccb66cf376949cc
https://doi.org/10.1158/1541-7786.22509643.v1
https://doi.org/10.1158/1541-7786.22509643.v1
Autor:
Donald Kufe, Mark D. Long, Song Liu, Henry Withers, Kwok-Kin Wong, Wenhao Suo, Zhou Luan, Yota Yasumizu, Masayuki Hagiwara, Caining Jin, Hasan Rajabi, Tatsuaki Daimon, Atrayee Bhattacharya, Nami Yamashita, Satoshi Ishikawa, Yoshihiro Morimoto, Atsushi Fushimi
Supplementary Figure from Dependence on the MUC1-C Oncoprotein in Classic, Variant, and Non–neuroendocrine Small Cell Lung Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5790caa7f84919492bc0965c704dcd60
https://doi.org/10.1158/1541-7786.22528077
https://doi.org/10.1158/1541-7786.22528077
PDF file - 622K, BT474/MUC1shRNA (A) and MCF-7/vector (B) cells were treated with fixed IC50 ratios of (i) GO-203 alone on days 0, 1, 2, 3 and 4, (ii) tamoxifen alone on days 0, 2 and 4 and (iii) the GO-203/tamoxifen combination. For tamoxifen-resist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dd462c93316129fccd21966da6b676d
https://doi.org/10.1158/1541-7786.22509640
https://doi.org/10.1158/1541-7786.22509640