Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Harvey W. Smith"'
Autor:
Ipshita Nandi, Linjia Ji, Harvey W. Smith, Daina Avizonis, Vasilios Papavasiliou, Cynthia Lavoie, Alain Pacis, Sherif Attalla, Virginie Sanguin-Gendreau, William J. Muller
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Metabolic reprogramming, a hallmark of tumorigenesis, involves alterations in glucose and fatty acid metabolism. Here, we investigate the role of Carnitine palmitoyl transferase 1a (Cpt1a), a key enzyme in long-chain fatty acid (LCFA) oxidat
Externí odkaz:
https://doaj.org/article/052dee2b00604ae3ada71ece23a9fb36
Autor:
Catherine R. Dufour, Hui Xia, Wafa B’chir, Marie-Claude Perry, Uros Kuzmanov, Anastasiia Gainullina, Kurt Dejgaard, Charlotte Scholtes, Carlo Ouellet, Dongmei Zuo, Virginie Sanguin-Gendreau, Christina Guluzian, Harvey W. Smith, William J. Muller, Etienne Audet-Walsh, Alexey A. Sergushichev, Andrew Emili, Vincent Giguère
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-17 (2022)
Murine hearts deficient in ErbB2 and/or ERRα are used to profile the adverse cardiac remodeling associated with potential targeted breast cancer treatments by phosphoproteomic, transcriptomic and metabolomic profiling.
Externí odkaz:
https://doaj.org/article/ddcceb39187b47f3a0dc86d4bc298e2e
Autor:
Ipshita Nandi, Harvey W. Smith, Virginie Sanguin-Gendreau, Linjia Ji, Alain Pacis, Vasilios Papavasiliou, Dongmei Zuo, Stella Nam, Sherif S. Attalla, Sung Hoon Kim, Sierra Lusson, Hellen Kuasne, Anne-Marie Fortier, Paul Savage, Constanza Martinez Ramirez, Morag Park, John A. Katzenellenbogen, Benita S. Katzenellenbogen, William J. Muller
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 7 (2023)
Activation of the tyrosine kinase c-Src promotes breast cancer progression and poor outcomes, yet the underlying mechanisms are incompletely understood. Here, we have shown that deletion of c-Src in a genetically engineered model mimicking the lumina
Externí odkaz:
https://doaj.org/article/6febccb2e0664106aef4e61bab5617dd
Autor:
Harvey W. Smith, Alison Hirukawa, Virginie Sanguin-Gendreau, Ipshita Nandi, Catherine R. Dufour, Dongmei Zuo, Kristofferson Tandoc, Matthew Leibovitch, Salendra Singh, Jonathan P. Rennhack, Matthew Swiatnicki, Cynthia Lavoie, Vasilios Papavasiliou, Carolin Temps, Neil O. Carragher, Asier Unciti-Broceta, Paul Savage, Mark Basik, Vincent van Hoef, Ola Larsson, Caroline L. Cooper, Ana Cristina Vargas Calderon, Jane Beith, Ewan Millar, Christina Selinger, Vincent Giguère, Morag Park, Lyndsay N. Harris, Vinay Varadan, Eran R. Andrechek, Sandra A. O’Toole, Ivan Topisirovic, William J. Muller
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Polycomb Repressor Complex 2 (PRC2) is frequently up-regulated in cancers. Here, the authors show that the tyrosine kinase c-Src stimulates mitochondrial function to signal energy sufficiency to mTORC1, increasing translation of the PRC2 subunits EZH
Externí odkaz:
https://doaj.org/article/4b4ac9959bb3404bb739e2634c53409f
Autor:
Alison Hirukawa, Salendra Singh, Jarey Wang, Jonathan P. Rennhack, Matthew Swiatnicki, Virginie Sanguin-Gendreau, Dongmei Zuo, Kamilia Daldoul, Cynthia Lavoie, Morag Park, Eran R. Andrechek, Thomas F. Westbrook, Lyndsay N. Harris, Vinay Varadan, Harvey W. Smith, William J. Muller
Publikováno v:
Cell Reports, Vol 29, Iss 2, Pp 249-257.e8 (2019)
Summary: Monoclonal antibodies (mAbs) targeting the oncogenic receptor tyrosine kinase ERBB2/HER2, such as Trastuzumab, are the standard of care therapy for breast cancers driven by ERBB2 overexpression and activation. However, a substantial proporti
Externí odkaz:
https://doaj.org/article/d72321d9dd27483ea95dfcd6db827f5b
Autor:
Alison Hirukawa, Harvey W. Smith, Dongmei Zuo, Catherine R. Dufour, Paul Savage, Nicholas Bertos, Radia M. Johnson, Tung Bui, Guillaume Bourque, Mark Basik, Vincent Giguère, Morag Park, William J. Muller
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Histone modifications in cancer can contribute to pathogenesis. Here, the authors demonstrate that targeting epigenetic modifier Ezh2 hinders metastatic behaviour in Luminal B breast cancer models, and highlight a mechanism where Ezh2 contributes to
Externí odkaz:
https://doaj.org/article/08e7c695e7a0496dbcbb93d281626f1b
Autor:
Jennifer F. Knight, Vanessa Y.C. Sung, Elena Kuzmin, Amber L. Couzens, Danielle A. de Verteuil, Colin D.H. Ratcliffe, Paula P. Coelho, Radia M. Johnson, Payman Samavarchi-Tehrani, Tina Gruosso, Harvey W. Smith, Wontae Lee, Sadiq M. Saleh, Dongmei Zuo, Hong Zhao, Marie-Christine Guiot, Ryan R. Davis, Jeffrey P. Gregg, Christopher Moraes, Anne-Claude Gingras, Morag Park
Publikováno v:
Cell Reports, Vol 22, Iss 12, Pp 3191-3205 (2018)
Summary: Triple-negative breast cancers (TNBCs) display a complex spectrum of mutations and chromosomal aberrations. Chromosome 5q (5q) loss is detected in up to 70% of TNBCs, but little is known regarding the genetic drivers associated with this eve
Externí odkaz:
https://doaj.org/article/f4500191f8be42e7bd824f4c692561b2
Autor:
Elaine Ngan, Konstantin Stoletov, Harvey W. Smith, Jessica Common, William J. Muller, John D. Lewis, Peter M. Siegel
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Lipoma preferred partner (LPP) mediates TGFβ-induced breast cancer cell migration and invasion. Here the authors show that LPP is a Src-family kinase substrate that regulates the formation of protrusions of the plasma membrane -called invadopodia- r
Externí odkaz:
https://doaj.org/article/7ea97a33e3164d48a89da3953228c9fb
Autor:
Geneviève Deblois, Harvey W. Smith, Ingrid S. Tam, Simon-Pierre Gravel, Maxime Caron, Paul Savage, David P. Labbé, Louis R. Bégin, Michel L. Tremblay, Morag Park, Guillaume Bourque, Julie St-Pierre, William J. Muller, Vincent Giguère
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Despite initial benefits in treating HER2-positive breast cancer patients with lapatinib, resistance is prevalent. Here the authors show that lapatinib resistance can be ascribed to mTOR-mediated re-activation of ERRα and to the consequent induction
Externí odkaz:
https://doaj.org/article/a807b71593d5451987bf6593688f61a3
Autor:
Josie Ursini-Siegel, William J. Muller, Claudia L. Kleinman, Young Kyuen Im, Eduardo Cepeda Cañedo, Steven Hébert, Valerie Sabourin, Harvey W. Smith, Ryuhjin Ahn, Jacqueline R. Ha
The commonality between most phospho-tyrosine signaling networks is their shared use of adaptor proteins to transduce mitogenic signals. ShcA (SHC1) is one such adaptor protein that employs two phospho-tyrosine binding domains (PTB and SH2) and key p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a1b890a55ac69f6fffa4d137ea60e32
https://doi.org/10.1158/1541-7786.c.6541126
https://doi.org/10.1158/1541-7786.c.6541126