The second law of black hole mechanics in effective field theory

Autor: Stefan Hollands, Áron D. Kovács, Harvey S. Reall

Publikováno v: Journal of High Energy Physics, Vol 2022, Iss 8, Pp 1-63 (2022)

Abstract We investigate the second law of black hole mechanics in gravitational theories with higher derivative terms in the action. Wall has described a method for defining an entropy that satisfies the second law to linear order in perturbations ar

Externí odkaz: https://doaj.org/article/2a8f7c9b6dd8470d92709d0774856568

Primary complex motor stereotypies are associated with de novo damaging DNA coding mutations that identify KDM5B as a risk gene.

Autor: Thomas V Fernandez, Zsanett P Williams, Tina Kline, Shreenath Rajendran, Farhan Augustine, Nicole Wright, Catherine A W Sullivan, Emily Olfson, Sarah B Abdallah, Wenzhong Liu, Ellen J Hoffman, Abha R Gupta, Harvey S Singer

Publikováno v: PLoS ONE, Vol 18, Iss 10, p e0291978 (2023)

Motor stereotypies are common in children with autism spectrum disorder (ASD), intellectual disability, or sensory deprivation, as well as in typically developing children ("primary" stereotypies, pCMS). The precise pathophysiological mechanism for m

Externí odkaz: https://doaj.org/article/b5acaf4738a646d28eb9d773e4b5a7cf

Pandemic intake questionnaire to improve quality, effectiveness, and efficiency of outpatient neurologic and developmental care at the Kennedy Krieger institute during the COVID-19 pandemic

Autor: Pooja Vedmurthy, Connor Murray, Belinda Chen, Akua Asiedu, Kristin Baranano, Mihee Bay, Harolyn Belcher, Vera Burton, Charles Conlon, Amena Fine, Ryan Gill, Jacqueline Harris, Khaylynn Hart, Shannon Inches, Jennifer Johnson, Eboni Lance, Paul H. Lipkin, Deepa U. Menon, Tiffany McIntyre, Meghna Rajaprakash, Albert Recio, Harvey S. Singer, Lindsay Smegal, Constance L. Smith-Hicks, Hilary Vernon, Anna Maria Wilms Floet, Joyce Wong, Karina Yelin, Mary L. O’Connor Leppert, T. Andrew Zabel, Anne M. Comi

Publikováno v: Frontiers in Rehabilitation Sciences, Vol 3 (2022)

BackgroundThe COVID-19 pandemic uniquely affects patients with neurologic and developmental disabilities at the Kennedy Krieger Institute. These patients are at increased risk of co-morbidities, increasing their risk of contracting COVID-19. Disrupti

Externí odkaz: https://doaj.org/article/def6c26024944610819643db055fa846

Synaptic processes and immune-related pathways implicated in Tourette syndrome

Autor: Fotis Tsetsos, Dongmei Yu, Jae Hoon Sul, Alden Y. Huang, Cornelia Illmann, Lisa Osiecki, Sabrina M. Darrow, Matthew E. Hirschtritt, Erica Greenberg, Kirsten R. Muller-Vahl, Manfred Stuhrmann, Yves Dion, Guy A. Rouleau, Harald Aschauer, Mara Stamenkovic, Monika Schlögelhofer, Paul Sandor, Cathy L. Barr, Marco A. Grados, Harvey S. Singer, Markus M. Nöthen, Johannes Hebebrand, Anke Hinney, Robert A. King, Thomas V. Fernandez, Csaba Barta, Zsanett Tarnok, Peter Nagy, Christel Depienne, Yulia Worbe, Andreas Hartmann, Cathy L. Budman, Renata Rizzo, Gholson J. Lyon, William M. McMahon, James R. Batterson, Danielle C. Cath, Irene A. Malaty, Michael S. Okun, Cheston Berlin, Douglas W. Woods, Paul C. Lee, Joseph Jankovic, Mary M. Robertson, Donald L. Gilbert, Lawrence W. Brown, Barbara J. Coffey, Andrea Dietrich, Pieter J. Hoekstra, Samuel Kuperman, Samuel H. Zinner, Michael Wagner, James A. Knowles, A. Jeremy Willsey, Jay A. Tischfield, Gary A. Heiman, Nancy J. Cox, Nelson B. Freimer, Benjamin M. Neale, Lea K. Davis, Giovanni Coppola, Carol A. Mathews, Jeremiah M. Scharf, Peristera Paschou, on behalf of the Tourette Association of America International Consortium for Genetics, Sabrina Darrow, Roger Kurlan, James F. Leckman, Jan H. Smit, the Gilles de la Tourette GWAS Replication Initiative, Harald Aschauer Harald Aschauer, Anastasios Konstantinidis, Kirsten Müller-Vahl, Tomasz Wolanczyk, the Tourette International Collaborative Genetics Study, Lawrence Brown, Keun-Ah Cheon, Blanca Garcia-Delgar, Donald Gilbert, Dorothy E. Grice, Julie Hagstrøm, Tammy Hedderly, Isobel Heyman, Chaim Huyser, Young Key Kim, Young-Shin Kim, Yun-Joo Koh, Sodahm Kook, Bennett L. Leventhal, Marcos Madruga-Garrido, Pablo Mir, Astrid Morer, Alexander Münchau, Kerstin J. Plessen, Veit Roessner, Eun-Young Shin, Dong-Ho Song, Jungeun Song, Samuel Zinner, and the Psychiatric Genomics Consortium Tourette Syndrome Working Group, Thomas Fernandez, Gary Heiman, Pieter Hoekstra, Jay Tischfield, Douglas Woods

Publikováno v: Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)

Abstract Tourette syndrome (TS) is a neuropsychiatric disorder of complex genetic architecture involving multiple interacting genes. Here, we sought to elucidate the pathways that underlie the neurobiology of the disorder through genome-wide analysis

Externí odkaz: https://doaj.org/article/1e03ee514141459ab171b2316307b113

Cardiac CT angiography in current practice: An American society for preventive cardiology clinical practice statement✰

Autor: Matthew J. Budoff, Suvasini Lakshmanan, Peter P. Toth, Harvey S. Hecht, Leslee J. Shaw, David J. Maron, Erin D. Michos, Kim A. Williams, Khurram Nasir, Andrew D. Choi, Kavitha Chinnaiyan, James Min, Michael Blaha

Publikováno v: American Journal of Preventive Cardiology, Vol 9, Iss , Pp 100318- (2022)

In this clinical practice statement, we represent a summary of the current evidence and clinical applications of cardiac computed tomography (CT) in evaluation of coronary artery disease (CAD), from an expert panel organized by the American Society f

Externí odkaz: https://doaj.org/article/c46a2c06e1004badb4b1b3c8e7bd882a