Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Harvey J. Kliman"'
Autor:
Kimberly C. Olney, Seema B. Plaisier, Tanya N. Phung, Michelle Silasi, Lauren Perley, Jane O’Bryan, Lucia Ramirez, Harvey J. Kliman, Melissa A. Wilson
Publikováno v:
Biology of Sex Differences, Vol 13, Iss 1, Pp 1-18 (2022)
Highlights Sex differences in gene expression in late first trimester placentas are positively correlated with sex differences in gene expression in full-term placentas; sex differences develop early and are maintained. Sex differences in gene expres
Externí odkaz:
https://doaj.org/article/7b29db30d1954adfa66300c64ec18551
Autor:
Tanya N. Phung, Kimberly C. Olney, Brendan J. Pinto, Michelle Silasi, Lauren Perley, Jane O’Bryan, Harvey J. Kliman, Melissa A. Wilson
Publikováno v:
HGG Advances, Vol 3, Iss 4, Pp 100142- (2022)
Externí odkaz:
https://doaj.org/article/63d685054dd84d2987e43962bcdd2707
Autor:
Anika K. Anam, Katherine M. Cooke, Milana Bochkur Dratver, Jane V. O'Bryan, Lauren E. Perley, Seth M. Guller, Janice J. Hwang, Hugh S. Taylor, Leigh Goedeke, Harvey J. Kliman, Daniel F. Vatner, Clare A. Flannery
Publikováno v:
Molecular Metabolism, Vol 64, Iss , Pp 101574- (2022)
Objective: Maternal obesity increases the incidence of excess adiposity in newborns, resulting in lifelong diabetes risk. Elevated intrauterine fetal adiposity has been attributed to maternal hyperglycemia; however, this hypothesis does not account f
Externí odkaz:
https://doaj.org/article/a8bb53ee4a7c489ab796cfa2fd1ff271
Autor:
Daniel Feliciano, Carolyn M. Ott, Isabel Espinosa-Medina, Aubrey V. Weigel, Lorena Benedetti, Kristin M. Milano, Zhonghua Tang, Tzumin Lee, Harvey J. Kliman, Seth M. Guller, Jennifer Lippincott-Schwartz
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Cells in many tissues fuse into syncytia acquiring new functions. By investigating whether physical remodelling promotes differentiation, here, the authors show that plasma membrane diminution post-fusion causes transient nutrient stress that inhibit
Externí odkaz:
https://doaj.org/article/d6d425d62b8e4205a0ee1957f8d2d03b
Autor:
Morgan R. Firestein, Harvey J. Kliman, Ayesha Sania, Lucy T. Brink, Parker H. Holzer, Katherine M. Hofmann, Kristin M. Milano, Nicolò Pini, Lauren C. Shuffrey, Hein J. Odendaal, William P. Fifer
Publikováno v:
PLoS ONE, Vol 17, Iss 3 (2022)
Objective Trophoblast inclusions—cross sections of abnormal trophoblast bilayer infoldings—have previously been associated with aneuploidy, placenta accreta, and prematurity. This study was conducted to establish the relationship between trophobl
Externí odkaz:
https://doaj.org/article/5dd9a2743a374342a7de01ef71cf46ff
Publikováno v:
F&S Reports, Vol 1, Iss 1, Pp 2-4 (2020)
Externí odkaz:
https://doaj.org/article/3f5d9ceeb62f4edfaadf219ef95f8ec2
Publikováno v:
Placenta. 114:133-138
Introduction Trophoblast inclusions (TIs) are associated with aneuploidy and pregnancy loss and have thus been considered to be a marker of genetic abnormality. However, to date, no study has specifically explored whether TIs are a manifestation of f
Autor:
Harvey J. Kliman, Lorena Benedetti, Zhonghua Tang, Tzumin Lee, Isabel Espinosa-Medina, Jennifer Lippincott-Schwartz, Kristin M. Milano, Seth Guller, Aubrey V. Weigel, Carolyn Ott, Daniel Feliciano
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications
Cells in many tissues, such as bone, muscle, and placenta, fuse into syncytia to acquire new functions and transcriptional programs. While it is known that fused cells are specialized, it is unclear whether cell-fusion itself contributes to programma
Publikováno v:
Am J Pathol
Hyperactivation of the CXCL12-CXCR4 axis occurs in endometriosis; the therapeutic potential of treatments aimed at global inhibition of the axis was recently reported. Because CXCR4 is predominantly expressed on epithelial cells in the uterus, this s
Autor:
Harvey J. Kliman, Parker H. Holzer, Lucy Brink, Katherine M. Hofmann, Kristin M. Milano, Hein J. Odendaal, Morgan R. Firestein, William P. Fifer
Publikováno v:
Placenta
We sought to examine placentas enriched for trophoblast inclusions (TIs) in order to characterize, quantify, and examine the interrelations between subtypes of TIs to better understand their underlying biology. We examined a cohort of 600 placentas f