Systematic Evaluation of 1,2-Migratory Aptitude in Alkylidene Carbenes

Autor: Carl Poree, Harvey J. A. Dale, Guy C. Lloyd-Jones, Chris Nottingham

Publikováno v: Dale, H J A, Nottingham, C, Poree, C & Lloyd-Jones, G C 2021, ' Systematic Evaluation of 1,2-Migratory Aptitude in Alkylidene Carbenes ', Journal of the American Chemical Society, vol. 143, no. 4, pp. 2097-2107 . https://doi.org/10.1021/jacs.0c12400
Dale, H, Nottingham, C, Poree, C & Lloyd-Jones, G 2021, ' Systematic Evaluation of 1,2-Migratory Aptitude in Alkylidene Carbenes ', Journal of the American Chemical Society, vol. 143, no. 4, pp. 2097-2107 . https://doi.org/10.1021/jacs.0c12400

Alkylidene carbenes undergo rapid inter- and intramolecular reactions and rearrangements, including 1,2-migrations of β-substituents to generate alkynes. Their propensity for substituent migration exerts profound influence over the broader utility o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6e236f84c531fe65674eae3315cd05f
https://hdl.handle.net/20.500.11820/8ffc77c5-716e-4b45-b242-140ea203a6e1

Taming Ambident Triazole Anions: Regioselective Ion-Pairing Catalyzes Direct N-Alkylation with Atypical Regioselectivity

Autor: Harvey J. A. Dale, George Robert Hodges, Guy C. Lloyd-Jones

Publikováno v: Dale, H J A, Hodges, G & Lloyd-jones, G C 2019, ' Taming Ambident Triazole Anions: Regioselective Ion-Pairing Catalyzes Direct N-Alkylation with Atypical Regioselectivity ', Journal of the American Chemical Society . https://doi.org/10.1021/jacs.9b02786

Controlling the regioselectivity of ambident nucleophiles towards alkylating agents is a fundamental problem in heterocyclic chemistry. Unsubstituted triazoles are particularly challenging, often requiring inefficient stepwise protection-deprotection

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be17898ddcba22d85b034e3c47372d90
https://hdl.handle.net/20.500.11820/d44d7680-ad0d-4bad-8cda-4f657c48d38f