Overcoming Lot-to-Lot Variability in Protein Activity Using Epitope-Specific Calibration-Free Concentration Analysis.

Autor: Harvey IB; Translational Sciences and Diagnostics, Bristol-Myers Squibb, Princeton, New Jersey 08540, United States., Chilewski SD; Translational Sciences and Diagnostics, Bristol-Myers Squibb, Princeton, New Jersey 08540, United States., Bhosale D; Translational Sciences and Diagnostics, Bristol-Myers Squibb, Princeton, New Jersey 08540, United States., Tobia SE; Translational Sciences and Diagnostics, Bristol-Myers Squibb, Princeton, New Jersey 08540, United States., Gray C; Translational Sciences and Diagnostics, Bristol-Myers Squibb, Princeton, New Jersey 08540, United States., Gleason C; Global Biometrics and Data Sciences, Bristol-Myers Squibb, Princeton, New Jersey 08540, United States., Haulenbeek J; Translational Sciences and Diagnostics, Bristol-Myers Squibb, Princeton, New Jersey 08540, United States.

Publikováno v: Analytical chemistry [Anal Chem] 2024 Apr 23; Vol. 96 (16), pp. 6275-6281. Date of Electronic Publication: 2024 Apr 10.

A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2.

Autor: Hassan AO; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA., Kafai NM; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Dmitriev IP; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO 63110, USA., Fox JM; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA., Smith BK; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110, USA., Harvey IB; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Chen RE; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Winkler ES; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Wessel AW; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Case JB; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA., Kashentseva E; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO 63110, USA., McCune BT; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA., Bailey AL; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Zhao H; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., VanBlargan LA; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA., Dai YN; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Ma M; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Adams LJ; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Shrihari S; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA., Danis JE; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Gralinski LE; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA., Hou YJ; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA., Schäfer A; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA., Kim AS; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Keeler SP; Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA., Weiskopf D; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA., Baric RS; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA., Holtzman MJ; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA., Fremont DH; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110, USA; The Andrew M. and Jane M. Bursky Center for Human Immunology & Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO 63110, USA., Curiel DT; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO 63110, USA; The Andrew M. and Jane M. Bursky Center for Human Immunology & Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: dcuriel@wustl.edu., Diamond MS; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA; The Andrew M. and Jane M. Bursky Center for Human Immunology & Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: diamond@wusm.wustl.edu.

Publikováno v: Cell [Cell] 2020 Oct 01; Vol. 183 (1), pp. 169-184.e13. Date of Electronic Publication: 2020 Aug 19.

Replication-competent vesicular stomatitis virus vaccine vector protects against SARS-CoV-2-mediated pathogenesis.

Autor: Case JB; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Rothlauf PW; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.; Program in Virology, Harvard Medical School, Boston, MA, USA., Chen RE; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.; Departments of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, USA., Kafai NM; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.; Departments of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, USA., Fox JM; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Shrihari S; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., McCune BT; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Harvey IB; Departments of Biochemistry & Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USA., Smith B; Departments of Biochemistry & Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USA., Keeler SP; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.; Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO, USA., Bloyet LM; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA., Winkler ES; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.; Departments of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, USA., Holtzman MJ; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.; Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO, USA., Fremont DH; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.; Departments of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, USA.; Departments of Biochemistry & Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USA.; The Andrew M. and Jane M. Bursky Center for Human Immunology & Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, USA., Whelan SPJ; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA., Diamond MS; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.; Departments of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, USA.; The Andrew M. and Jane M. Bursky Center for Human Immunology & Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2020 Jul 10. Date of Electronic Publication: 2020 Jul 10.

Viral MHCI inhibition evades tissue-resident memory T cell formation and responses.

Autor: Lauron EJ; Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO., Yang L; Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO., Harvey IB; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO., Sojka DK; Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO., Williams GD; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO., Paley MA; Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO., Bern MD; Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO., Park E; Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO., Victorino F; Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO., Boon ACM; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO.; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO., Yokoyama WM; Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO yokoyama@wustl.edu.; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO.

Publikováno v: The Journal of experimental medicine [J Exp Med] 2019 Jan 07; Vol. 216 (1), pp. 117-132. Date of Electronic Publication: 2018 Dec 17.

An Intrinsically Disordered Peptide from Ebola Virus VP35 Controls Viral RNA Synthesis by Modulating Nucleoprotein-RNA Interactions.

Autor: Leung DW; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA., Borek D; Departments of Biophysics and Biochemistry and Center for Structural Genomics of Infectious Diseases, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA., Luthra P; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Binning JM; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA., Anantpadma M; Department of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, TX 78227, USA., Liu G; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA., Harvey IB; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA., Su Z; National Center for Macromolecular Imaging, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA., Endlich-Frazier A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Pan J; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA., Shabman RS; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Chiu W; National Center for Macromolecular Imaging, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA., Davey RA; Department of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, TX 78227, USA., Otwinowski Z; Departments of Biophysics and Biochemistry and Center for Structural Genomics of Infectious Diseases, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA., Basler CF; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Amarasinghe GK; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA. Electronic address: gamarasinghe@path.wustl.edu.

Publikováno v: Cell reports [Cell Rep] 2015 Apr 21; Vol. 11 (3), pp. 376-89. Date of Electronic Publication: 2015 Apr 09.