Genetic Architecture of Primary Open-Angle Glaucoma in Individuals of African Descent

Autor: Rajendra Bansal, Swapan K Das, Christopher A. Girkin, Lama A. Al-Aswad, Radha Ayyagari, Felipe A. Medeiros, Xiuqing Guo, Joseph F. Panarelli, Jeffrey M. Liebmann, Harvey Dubiner, Yii-Der Ida Chen, Yang Hai, Jasmin Divers, Kent D. Taylor, Garvin H. Davis, Donald W. Bowden, Barry I. Freedman, Robert N. Weinreb, Celso Tello, Nicholas P. Bell, Jeremy Cotliar, Robert Ritch, Paul A Sidoti, John P Mitchell, Nicholette D. Palmer, George A. Cioffi, Lauren S. Blieden, Sung Chul Park, Maggie C.Y. Ng, Brian C Samuels, Jerome I. Rotter, Linda M. Zangwill, Dana M. Blumberg, Carl D. Langefeld, African Descent, Robert M. Feldman

Publikováno v: Ophthalmology. 126:38-48

Purpose To find genetic contributions to glaucoma in African Americans. Design Cross-sectional, case-control study. Participants One thousand eight hundred seventy-five primary open-angle glaucoma (POAG) patients and 1709 controls, self-identified as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a33f8d29db78af600149183ef84dced
https://doi.org/10.1016/j.ophtha.2018.10.031

Association of Genetic Variants With Primary Open-Angle Glaucoma Among Individuals With African Ancestry

Autor: Carly J. van der Heide, Jessica N. Cooke Bailey, Susan Williams, Dan Milea, José Paulo Cabral de Vasconcellos, Sadiq M. Abdullahi, Douglas E. Gaasterland, Ifeoma N. Asimadu, Sayoko E. Moroi, Hasnaa Lamari, Sarah J. Garnai, Janey L. Wiggs, Donald L. Budenz, R. Rand Allingham, Julia E. Richards, Jonathan L. Haines, Jerome I. Rotter, Michael G. Anderson, Xiuqing Guo, Robert M. Feldman, Michael A. Hauser, Yii-Der Ida Chen, Hugo Freire Nunes, Leon W. Herndon, John F. Ervin, Stephen Akafo, Radha Ayyagari, Thomas J. Hoffmann, Rachel W. Kuchtey, Michèle Ramsay, Prisca Biangoup Nyamsi, Zheng Li, Eric Jorgenson, Kar Seng Sim, Ebenezer Obeng-Nyarkoh, William C. Bromley, Christopher A. Girkin, Robert N. Weinreb, Alberta A H J Thiadens, Serge Resnikoff, William E. Sponsel, Maggie C.Y. Ng, Christine M. Hulette, Donald W. Bowden, Saydou Bakayoko, Jeffrey M. Liebmann, Harvey Dubiner, Suhanya Okeke, Abba Hydara, Ruth J. F. Loos, Adeyinka O. Ashaye, Olusegun Olaniyi, Mahmoud B. Alhassan, Khaled K. Abu-Amero, Christopher J Hammond, Tin Aung, John H. Fingert, Robert P. Igo, Shih-Hsiu Wang, Rui Barroso Schimiti, Pratap Challa, Robert F. Mullins, Rodolfo A. Perez-Grossmann, Nouhoum Guirou, Margaret A. Pericak-Vance, Anthony Okeke, Pieter W.M. Bonnemaijer, Paulo Vinicius Svidnicki, Abdoulaye Napo, Louise R. Pasquale, Joyce Kabwe, Chiea Chuen Khor, Mônica Barbosa de Melo, Girish N. Nadkarni, CM Chuka-Okosa, Neil Risch, Nkiru Kizor-Akaraiwe, Miles J. Flamme-Wiese, Cornelia M. van Duijn, N J Uche, Joseph Msosa, Olusola Olawoye, Linda M. Zangwill, Mariana B. Oliveira, Caroline C W Klaver, Allison E. Ashley Koch, Vital Paulino Costa, Ngoy Janvier Kilangalanga, Trevor R. Carmichael, Xue Qin, Kent D. Taylor, Yutao Liu, Dianne A. Cruz

Publikováno v: JAMA-Journal of the American Medical Association, 322(17), 1682-1691. American Medical Association
Jama : Journal of the American Medical Association, 322, 17, pp. 1682-1691
JAMA
Jama : Journal of the American Medical Association, 322, 1682-1691

Importance: Primary open-angle glaucoma presents with increased prevalence and a higher degree of clinical severity in populations of African ancestry compared with European or Asian ancestry. Despite this, individuals of African ancestry remain unde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f34e3cbd9097c136f4a002c78cbfea9
https://doi.org/10.1001/jama.2019.16161

Ocular hypotensive effect of fixed-combination brinzolamide/brimonidine adjunctive to a prostaglandin analog: a randomized clinical trial

Autor: Harvey Dubiner, Robert D. Fechtner, D. L. Budenz, Douglas A Hubatsch, Jonathan S. Myers

Publikováno v: Eye

Purpose To determine whether intraocular pressure (IOP) lowering with fixed-combination brinzolamide/brimonidine (BBFC) adjunctive to a prostaglandin analog (PGA) was superior to that of vehicle+PGA in patients with open-angle glaucoma or ocular hype

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48770378bfbd7874e869a694b1be6892
https://doi.org/10.1038/eye.2016.126

Oral administration of the 11β-hydroxysteroid-dehydrogenase type 1 inhibitor RO5093151 to patients with glaucoma: an adaptive, randomised, placebo-controlled clinical study

Autor: Agnès Portron, Dietmar Schwab, Harvey Dubiner, Carolina Sturm, Paul Jordan, Sabine Fuerst-Recktenwald, William C. Stewart, Michael E Tepedino, Dominik Hainzl

Publikováno v: BMJ Open Ophthalmology

Background/aims Cortisol is involved in the regulation of intraocular pressure (IOP). This study aimed to assess the effect of 11β-hydroxysteroid-dehydrogenase type 1 (11βHSD1) inhibition by oral administration of RO5093151 on IOP. Methods The expo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38c65cc9a6d0003729a16e9eb67b41a9
http://europepmc.org/articles/PMC5721631

A Dose-Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of 2 and 4 Weeks of Twice-Daily Ocular Trabodenoson in Adults with Ocular Hypertension or Primary Open-Angle Glaucoma

Autor: Cadmus C Rich, Mcvicar William K, Kenneth N Sall, Rudolf A. Baumgartner, Harvey Dubiner, Natanya Slomowitz, Jonathan S. Myers

Publikováno v: Journal of Ocular Pharmacology and Therapeutics

Purpose: To evaluate the safety and ocular hypotensive efficacy of 4 trabodenoson doses administered twice daily over 14 or 28 days in subjects with ocular hypertension or primary open-angle glaucoma (POAG). Methods: In this multicenter, randomized,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::501dfbed3a67c181fe65e293b82c2c10
https://pubmed.ncbi.nlm.nih.gov/27002298