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Akademický článek

Retrospective Assessment of Translational Pharmacokinetic–Pharmacodynamic Modeling Performance: A Case Study with Apitolisib, a Dual PI3K/mTOR Inhibitor

Autor: Anita Moein, Jin Y. Jin, Matthew R. Wright, Bruno Alicke, Harvey Wong

Publikováno v: Drugs in R&D, Vol 24, Iss 2, Pp 155-167 (2024)

Abstract Background and Objectives Despite significant progress in biomedical research, the rate of success in oncology drug development remains inferior to that of other therapeutic fields. Mechanistic models provide comprehensive understanding of t

Externí odkaz: https://doaj.org/article/edd67a37d356415091a99db705d813f0

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Akademický článek

Neutrophil elastase as a versatile cleavage enzyme for activation of αvβ3 integrin-targeted small molecule drug conjugates with different payload classes in the tumor microenvironment

Autor: Anne-Sophie Rebstock, Mareike Wiedmann, Beatrix Stelte-Ludwig, Harvey Wong, Amy J. Johnson, Raquel Izumi, Ahmed Hamdy, Hans-Georg Lerchen

Publikováno v: Frontiers in Pharmacology, Vol 15 (2024)

Introduction: The development of bioconjugates for the targeted delivery of anticancer agents is gaining momentum after recent success of antibody drug conjugates (ADCs) in the clinic. Smaller format conjugates may have several advantages including b

Externí odkaz: https://doaj.org/article/48196de27ca84870b273d09b3f4c3f6d

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Akademický článek

Time‐dependent clearance can confound exposure–response analysis of therapeutic antibodies: A comprehensive review of the current literature

Autor: Jeffrey R. Proctor, Harvey Wong

Publikováno v: Clinical and Translational Science, Vol 17, Iss 1, Pp n/a-n/a (2024)

Abstract Exposure–response (ER) analysis is used to optimize dose and dose regimens during clinical development. Characterization of relationships between drug exposure and efficacy or safety outcomes can be utilized to make dose adjustments that i

Externí odkaz: https://doaj.org/article/6501a33ae1d948689a848346cb263532

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Design and Measurement of Drug Tissue Concentration Asymmetry and Tissue Exposure-Effect (Tissue PK-PD) Evaluation

Autor: Richard Zang, Aline Barth, Harvey Wong, Jan Marik, Jie Shen, Julie Lade, Kerri Grove, Matthew R. Durk, Neil Parrott, Patrick J. Rudewicz, Sylvia Zhao, Tao Wang, Zhengyin Yan, Donglu Zhang

Publikováno v: Journal of Medicinal Chemistry. 65:8713-8734

The "free drug hypothesis" assumes that, in the absence of transporters, the steady state free plasma concentrations equal to that at the site of action that elicit pharmacologic effects. While it is important to utilize the free drug hypothesis, exc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed020e19b1e50a9215ac6334a3b2b529
https://doi.org/10.1021/acs.jmedchem.2c00502

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Physiologically Based Pharmacokinetic Models Can Be Used to Predict the Unique Nonlinear Absorption Profiles of Vismodegib

Autor: Louis, Lin, Matthew R, Wright, Cornelis E C A, Hop, Harvey, Wong

Publikováno v: Drug Metabolism and Disposition. 50:1170-1181

Predicting human pharmacokinetics (PK) during the drug discovery phase is valuable to assess doses required to reach therapeutic exposures. For orally administered compounds, however, this can be especially difficult, since the absorption process is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bec14b990ffa11253a076ca46a73d1f1
https://doi.org/10.1124/dmd.122.000885

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