Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Haruyuki Nishida"'
Autor:
Yasunobu Hori, Akio Imanishi, Naoki Tarui, Yasushi Fujioka, Toshihiro Imaeda, Fumio Itoh, Mitsuyo Kondo, Haruyuki Nishida, Koji Ono, Masahiro Kajino, Kazuo Nakai, Nobuhiro Inatomi, Jun Matsukawa, Terufumi Takagi
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:3719-3735
With the aim to discover a gastric antisecretory agent more potent than the existing proton pump inhibitors, novel 3,4-dihydro-1H-spiro(naphthalene-2,2'-piperidin)-1-one derivatives, which could occupy two important lipophilic pockets (described as L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b24660c0fa82967a04b22a0fe1f9f9a0
https://doi.org/10.1016/j.bmc.2017.05.012
https://doi.org/10.1016/j.bmc.2017.05.012
Publikováno v:
Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 152(3)
Proton pump inhibitors (PPIs) inhibit H+, K+-ATPase, an enzyme which is the final step of gastric acid secretion and is selectively located in the gastric parietal cells. PPIs block the enzyme in a covalent and irreversible binding manner, thus provi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d24ecb75fb8a934d8032c29934a7557b
https://pubmed.ncbi.nlm.nih.gov/30185727
https://pubmed.ncbi.nlm.nih.gov/30185727
Autor:
Hideo Fukui, Ikuo Fujimori, Nobuhiro Inatomi, Koji Ono, Keizo Hirase, Haruyuki Nishida, Akio Imanishi, Yasuyoshi Arikawa, Fumio Itoh, Yasunobu Hori, Jun Matsukawa, Kazuo Nakai, Yasushi Fujioka
Publikováno v:
Bioorganicmedicinal chemistry. 25(13)
With the aim to discover a novel excellent potassium-competitive acid blocker (P-CAB) that could perfectly overcome the limitations of proton pump inhibitors (PPIs), we tested various approaches based on pyrrole derivative 1 as a lead compound. As pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbc7a1db9c3bce976c446c8b740f5b32
https://pubmed.ncbi.nlm.nih.gov/28483454
https://pubmed.ncbi.nlm.nih.gov/28483454
Autor:
Yasuyoshi Arikawa, Yasushi Fujioka, Motoo Iida, Mitsuyoshi Nishitani, Jun Matsukawa, Toshihiro Imaeda, Teruki Hamada, Yasunobu Hori, Fumio Itoh, Keizo Hirase, Nobuhiro Inatomi, Akio Imanishi, Haruyuki Nishida, Hideo Fukui, Masahiro Kajino
Publikováno v:
Bioorganicmedicinal chemistry. 25(13)
With the aim to find a novel long-lasting potassium-competitive acid blocker (P-CAB) that would perfectly overcome the limitations of proton pump inhibitors (PPIs), we tried various approaches based on pyrrole derivative 1b as a lead compound. As par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bac684f5eccfc18c3228e16d7323bb0
https://pubmed.ncbi.nlm.nih.gov/28442261
https://pubmed.ncbi.nlm.nih.gov/28442261
Autor:
Haruyuki Nishida
Publikováno v:
Successful Drug Discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6be790750a19e8a373f7eb2b1c918ba
https://doi.org/10.1002/9783527800315.ch10
https://doi.org/10.1002/9783527800315.ch10
Autor:
Hitomi Yamasaki, Keiichi Otsuka, Yoshihiko Tagawa, Masatoshi Karashima, Yuuichi Sakurai, Kazuyoshi Otake, Haruyuki Nishida, Nobuhiro Inatomi, Hideo Fukui
Publikováno v:
Advances in therapy. 33(7)
Proton pump inhibitors (PPIs) are widely prescribed as first-line therapy for the treatment of acid-related diseases, such as peptic ulcers and gastro-esophageal reflux disease, and for the eradication of Helicobacter pylori. However, the therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c7e00345505408f4047d40eb0468cc6
https://pubmed.ncbi.nlm.nih.gov/27287852
https://pubmed.ncbi.nlm.nih.gov/27287852
Autor:
Mitsuyo Kondo, Haruyuki Nishida, Akio Imanishi, Naoki Tarui, Osamu Kurasawa, Masahiro Kajino, Atsushi Hasuoka, Terufumi Takagi, Yasunobu Hori, Nobuhiro Inatomi, Yasuyoshi Arikawa, Fumihiko Sato, Keizo Hirase
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:3925-3938
To discover a gastric antisecretory agent more potent than existing proton pump inhibitors, novel pyrrole derivatives were synthesized, and their H(+),K(+)-ATPase inhibitory activities and inhibitory action on histamine-stimulated gastric acid secret
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d11ebe86ca05c17801e0975dc7cca300
https://doi.org/10.1016/j.bmc.2012.04.014
https://doi.org/10.1016/j.bmc.2012.04.014
Autor:
Atsushi Hasuoka, Mitsuyo Kondo, Haruyuki Nishida, Yasuyoshi Arikawa, Terufumi Takagi, Akio Imanishi, Nobuhiro Inatomi, Osamu Kurasawa, Yasunobu Hori, Keizo Hirase, Masahiro Kajino, Naoki Tarui, Teruki Hamada, Jun Matsukawa, Toshiyuki Takeuchi
Publikováno v:
Journal of Medicinal Chemistry. 55:4446-4456
In our pursuit of developing a novel and potent potassium-competitive acid blocker (P-CAB), we synthesized pyrrole derivatives focusing on compounds with low log D and high ligand-lipophilicity efficiency (LLE) values. Among the compounds synthesized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11eb3b6a9b221556449e78c91290c08b
https://doi.org/10.1021/jm300318t
https://doi.org/10.1021/jm300318t
Autor:
Makiko Kawamoto, Yasuyoshi Arikawa, Masahiro Kajino, Fumio Itoh, Naoki Tarui, Atsushi Hasuoka, Nobuhiro Inatomi, Keizo Hirase, Akio Imanishi, Terufumi Takagi, Haruyuki Nishida
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(10)
On the basis of a series of novel and potent potassium-competitive acid blockers represented by 1-sulfonylpyrrole derivative 7 , we prepared several five-membered heterocyclic analogues ( 8 ) and evaluated their H + ,K + -ATPase activities in vitro.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fbd9af2102df0d430832c5da6ce8e8e
https://pubmed.ncbi.nlm.nih.gov/25891103
https://pubmed.ncbi.nlm.nih.gov/25891103
Autor:
Jun Matsukawa, Haruyuki Nishida, Yasunobu Hori, Nobuhiro Inatomi, Masahiro Kajino, Toshiyuki Takeuchi
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 337(3)
Proton pump inhibitors (PPIs) are widely used for the treatment of acid-related diseases. However, several medical needs such as suppression of night-time acid secretion and rapid symptom relief remain unmet. In this study, we investigated the effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b39139f00625d79848726f1bf8558c5
https://pubmed.ncbi.nlm.nih.gov/21411494
https://pubmed.ncbi.nlm.nih.gov/21411494