Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Haruyoshi Shirai"'
Autor:
Naoki Harada, Kiyoshi Yoshinari, Kenji Takanashi, Noriyuki Furuichi, Ikumi Hyohdoh, Kazutomo Ori, Mitsuyasu Tabo, Fumio Watanabe, Haruyoshi Shirai, Yasushi Tomii, Nobuo Shimma, Pil-Su Ho, Toshihiro Aoki, Hitoshi Iikura, Sawako Ozawa, Masahiro Sakaitani, Yuko Aoki, Yoshiko Itezono, Masayuki Matsushita
Publikováno v:
ACS Medicinal Chemistry Letters. 4:1059-1063
A facile methodology effective in obtaining a set of compounds monofluorinated at various positions (fluorine scan) by chemical synthesis is reported. Direct and nonselective fluorination reactions of our lead compound 1a and key intermediate 2a work
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd743460b41c992b38ef8f3fe1eef0ac
https://doi.org/10.1021/ml4002419
https://doi.org/10.1021/ml4002419
Autor:
Takahide Watanabe, Toshikazu Yamazaki, Tomoaki Inoue, Yasuko Satoh, Kazuko Kobayashi, Kazunao Masubuchi, Takehiro Okada, Ikuo Horii, Eisaku Mizuguchi, Masahiro Aoki, Masahiro Sakaitani, Haruyoshi Shirai, Nobuo Shimma, Masami Kohchi, Osamu Kondoh
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:395-398
Highly potent 1,3-β- d -glucan synthase inhibitors, 7b , 10a , 10b and 12 , have been identified by the chemical modification of the ornithine residue of a fungicidal macrocyclic lipopeptidolactone, RO-09-3655 ( 1 ), isolated from the cultured broth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f374759851a3051aa561e0e41c116c5c
https://doi.org/10.1016/s0960-894x(00)00678-8
https://doi.org/10.1016/s0960-894x(00)00678-8
Autor:
Mitsuko Mori, Shoichi Ohshima, Kazuteru Yokose, Yoshiko Itezono, Noboru Nakayama, Masahiro Aoki, Haruyoshi Shirai, Tomoko Satoh, Haruo Seto, J. Watanabe
Publikováno v:
The Journal of Antibiotics. 44:635-645
Avidinorubicin (MW 1,214, C60H86N4O22) was isolated from the cultured broth of strain NR0576 (which was identified as Streptomyces avidinii Stapley et al.) by butyl alcohol extraction, Sephadex LH-20 column chromatography and preparative HPLC. Avidin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d4e30b7a1b75dd40f53635dbff19d31
https://doi.org/10.7164/antibiotics.44.635
https://doi.org/10.7164/antibiotics.44.635
Autor:
Nobuo Shimma, Yutaka Tanaka, Akiko Yamaguchi, Haruo Seto, Yoshiko Itezono, Kazuteru Yokose, Noboru Nakayama, Masahiro Aoki, Haruyoshi Shirai, Akiko Sakai
Publikováno v:
Tetrahedron Letters. 32:4737-4740
Vinaxanthone is a novel phospholipase C inhibitor produced by Penicillium vinaceum Gilman and About NR6815. Its structre (MW 576, C28H16O14) has been elucidated as a polycyclic xanthone with poly acidic functional groups based on various NMR studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89246046325d43b4c23601a60a48c2be
https://doi.org/10.1016/s0040-4039(00)92295-0
https://doi.org/10.1016/s0040-4039(00)92295-0
Autor:
Kohsuke Aso, Kotaroh Ogawa, Yoshiaki Isshiki, Eisaku Mizuguchi, Kiyoshi Yoshinari, Yukiko Inagaki, Masako Ura, Kazuo Hattori, Hideo Ishitsuka, Hisafumi Okabe, Masanori Miwa, Haruyoshi Shirai, Nobuo Shimma, Yasunori Chugai Seiyaku Kabushiki Kaisha Kohchi, Nobuhiro Oikawa
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(8)
DNA microarray analysis comparing human tumor tissues with normal tissues including hematopoietic progenitor cells resulted in identification of membrane dipeptidase as a prodrug activation enzyme. Novel prodrugs of 2'-deoxy-2'-methylidenecytidine (D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79635ebb83a9d1b378df558efd7545b6
https://pubmed.ncbi.nlm.nih.gov/17306533
https://pubmed.ncbi.nlm.nih.gov/17306533
Autor:
Yoshiko Itezono, Tatsuo Ohtsuka, Toru Okuda, Shoko Matsukuma, Nobuo Shimma, Kimihiro Watanabe, Kazuteru Yokose, Haruyoshi Shirai, Kotaki Hiromichi, Morio Fujiu, Noboru Nakayama, Takashi Sano
Publikováno v:
The Journal of antibiotics. 45(2)
A new series of antifungal antibiotics, Ro 09-1470 and its 6 congeners were isolated from the fermentation broth of Penicillium sp. NR6564. Their structures were determined as tetrahydropyran derivatives with an alkenyl side chain on the basis of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::757a8abf5559889e55c6bc004fe1d7eb
https://pubmed.ncbi.nlm.nih.gov/1556006
https://pubmed.ncbi.nlm.nih.gov/1556006
Autor:
Yoosuke Yamada, Hiromi B. Maruyama, Y. Ninomiya, Mitsuko Onitsuka, Haruyoshi Shirai, Yasuji Suhara
Publikováno v:
Chemical and Pharmaceutical Bulletin. 28:3157-3162
Pyrrothines, known as broad-spectrum antibiotics, showed potent membrane stabilization and platelet anti-aggregant activities. Thiolutin, the most potent among them, is three times as active as indomethacin in HH, APA and CPA, but has no activity in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14a79e6643efb87b0d0318309d9bfa68
https://doi.org/10.1248/cpb.28.3157
https://doi.org/10.1248/cpb.28.3157
Autor:
YASUJI SUHARA, HIROMI B. MARUYAMA, YOSHIAKI KOTOH, YUMIKO MIYASAKA, KAZUTERU YOKOSE, HARUYOSHI SHIRAI, KOUICHI TAKANO
Publikováno v:
The Journal of antibiotics. 28(9)
A new antibiotic fumaramidmycin produced by Streptomyces kurssanovii NR-7GG1 was isolated as colorless crystals. The structure was shown to be N-(phenylacetyl) fumaramide. Starting from fumaramic acid, fumaramidmycin has been synthesized in good yiel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cce420d2f201fa2519455dd9a0be53b9
https://pubmed.ncbi.nlm.nih.gov/1184478
https://pubmed.ncbi.nlm.nih.gov/1184478