Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Harutsugu, Tatebe"'
Autor:
Kenji Tagai, Harutsugu Tatebe, Sayo Matsuura, Zhang Hong, Naomi Kokubo, Kiwamu Matsuoka, Hironobu Endo, Asaka Oyama, Kosei Hirata, Hitoshi Shinotoh, Yuko Kataoka, Hideki Matsumoto, Masaki Oya, Shin Kurose, Keisuke Takahata, Masanori Ichihashi, Manabu Kubota, Chie Seki, Hitoshi Shimada, Yuhei Takado, Kazunori Kawamura, Ming-Rong Zhang, Yoshiyuki Soeda, Akihiko Takashima, Makoto Higuchi, Takahiko Tokuda
Publikováno v:
Translational Neurodegeneration, Vol 13, Iss 1, Pp 1-5 (2024)
Externí odkaz:
https://doaj.org/article/7c34e3413c9e47fabe9c650ddabe1a10
Autor:
Keita Hiraga, Makoto Hattori, Yuki Satake, Daigo Tamakoshi, Taiki Fukushima, Takashi Uematsu, Takashi Tsuboi, Maki Sato, Katsunori Yokoi, Keisuke Suzuki, Yutaka Arahata, Yukihiko Washimi, Akihiro Hori, Masayuki Yamamoto, Hideaki Shimizu, Masakazu Wakai, Harutsugu Tatebe, Takahiko Tokuda, Akinori Nakamura, Shumpei Niida, Masahisa Katsuno
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-11 (2024)
Abstract Comorbid Alzheimer’s disease (AD) neuropathology is common in Lewy body disease (LBD); however, AD comorbidity in the prodromal phase of LBD remains unclear. This study investigated AD comorbidity in the prodromal and symptomatic phases of
Externí odkaz:
https://doaj.org/article/6c580b4813af4d3f98397e9dbd06a241
Autor:
Gen Sobue, Hirofumi Maruyama, Keiko Imamura, Yuishin Izumi, Satoshi Morita, Naohiro Egawa, Takashi Ayaki, Makiko Nagai, Kazutoshi Nishiyama, Yasuhiro Watanabe, Ritsuko Hanajima, Koji Fujita, Naoto Takahashi, Akiko Morinaga, Ryosuke Takahashi, Haruhisa Inoue, Naoki Atsuta, Osamu Kano, Takehisa Hirayama, Takao Kiriyama, Hiroshi Kataoka, Takahiko Tokuda, Kazuma Sugie, Takenobu Murakami, Hitoki Nanaura, Masahiro Nakamori, Shotaro Haji, Harutsugu Tatebe, Riko Tabuchi, Motoki Oe, Mihoko Kobayashi, Kasia Lobello
Publikováno v:
BMJ Open, Vol 14, Iss 10 (2024)
Introduction Amyotrophic lateral sclerosis (ALS) is a progressive, severe neurodegenerative disease caused by motor neuron death. Development of a medicine for ALS is urgently needed, and induced pluripotent cell-based drug repurposing identified a S
Externí odkaz:
https://doaj.org/article/63d3495d00e24d60a205cd5377da8720
Enzymatic properties and clinical associations of serum alpha‐galactosidase A in Parkinson's disease
Autor:
Yasuaki Mizutani, Kazuki Nawashiro, Reiko Ohdake, Harutsugu Tatebe, Sayuri Shima, Akihiro Ueda, Junichiro Yoshimoto, Mizuki Ito, Takahiko Tokuda, Tatsuro Mutoh, Hirohisa Watanabe
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 10, Iss 9, Pp 1662-1672 (2023)
Abstract Objective Recent studies have revealed an association between Parkinson's disease (PD) and Fabry disease, a lysosomal storage disorder; however, the underlying mechanisms remain to be elucidated. This study aimed to investigate the enzymatic
Externí odkaz:
https://doaj.org/article/683fb3ea79ea4fa19bfde6213ef17128
Publikováno v:
Heliyon, Vol 10, Iss 2, Pp e24672- (2024)
The level of TAR DNA-binding protein 43 (TDP-43) in human blood was reported to have potential for use as a specific fluid biomarker, which represents disease-specific pathologies, for TDP-43 proteinopathies, including amyotrophic lateral sclerosis (
Externí odkaz:
https://doaj.org/article/9c46ca2f42b64796a90c49ab0959c0e7
Autor:
Kiwamu Matsuoka, Kosei Hirata, Naomi Kokubo, Takamasa Maeda, Kenji Tagai, Hironobu Endo, Keisuke Takahata, Hitoshi Shinotoh, Maiko Ono, Chie Seki, Harutsugu Tatebe, Kazunori Kawamura, Ming-Rong Zhang, Hitoshi Shimada, Takahiko Tokuda, Makoto Higuchi, Yuhei Takado
Publikováno v:
NeuroImage: Clinical, Vol 41, Iss , Pp 103560- (2024)
In Alzheimer’s disease (AD), aggregated abnormal proteins induce neuronal dysfunction. Despite the evidence supporting the association between tau proteins and brain atrophy, further studies are needed to explore their link to neuronal dysfunction
Externí odkaz:
https://doaj.org/article/e8deeb2471ab4de6915f76e8acd8bb04
Autor:
Makiko Shinomoto, Takashi Kasai, Harutsugu Tatebe, Fukiko Kitani-Morii, Takuma Ohmichi, Yuzo Fujino, David Allsop, Toshiki Mizuno, Takahiko Tokuda
Publikováno v:
Translational Neurodegeneration, Vol 10, Iss 1, Pp 1-3 (2021)
Externí odkaz:
https://doaj.org/article/68fb567fa5ee4e27844fbe696160536b
Autor:
Takashi Kasai, Yuta Kojima, Takuma Ohmichi, Harutsugu Tatebe, Yukiko Tsuji, Yu‐ichi Noto, Fukiko Kitani‐Morii, Makiko Shinomoto, David Allsop, Toshiki Mizuno, Takahiko Tokuda
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 6, Iss 12, Pp 2489-2502 (2019)
Abstract Objective To determine the diagnostic and prognostic significance of neurofilament light chain (NfL), TAR DNA‐binding protein 43 (TDP‐43), and total tau (t‐tau) in cerebrospinal fluid (CSF) and plasma of patients with amyotrophic later
Externí odkaz:
https://doaj.org/article/86f29760cde3462d884f3cfd82198694
Autor:
Yuta Kojima, Takashi Kasai, Yu-Ichi Noto, Takuma Ohmichi, Harutsugu Tatebe, Takamasa Kitaoji, Yukiko Tsuji, Fukiko Kitani-Morii, Makiko Shinomoto, David Allsop, Satoshi Teramukai, Toshiki Mizuno, Takahiko Tokuda
Publikováno v:
PLoS ONE, Vol 16, Iss 11, p e0260323 (2021)
ObjectivesWe previously reported the diagnostic and prognostic performance of neurofilament light chain (NfL), TAR DNA-binding protein 43 (TDP-43), and total tau (t-tau) in cerebrospinal fluid (CSF) and plasma as amyotrophic lateral sclerosis (ALS) b
Externí odkaz:
https://doaj.org/article/f8604d5267cb4fb499b7d4aabba5829d
Autor:
Takuma Ohmichi, Takashi Kasai, Makiko Shinomoto, Jun Matsuura, Takashi Koizumi, Fukiko Kitani-Morii, Harutsugu Tatebe, Hidenao Sasaki, Toshiki Mizuno, Takahiko Tokuda
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Caffeine is considered to be a neuroprotective agent against Parkinson's disease (PD) and is expected to offer a blood-based biomarker for the disease. We herein investigated the ability of this biomarker to discriminate between PD and neurodegenerat
Externí odkaz:
https://doaj.org/article/9fd87767385e4b8eb25577f7a1f5ef65