Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Harushige Ozaki"'
Publikováno v:
Frontiers in Neural Circuits, Vol 15 (2021)
Subarachnoid hemorrhage (SAH) is a life-threatening condition that can also lead to permanent paralysis. However, the mechanisms that underlying neurobehavioral deficits after SAH have not been fully elucidated. As theta burst stimulation (TBS) can i
Externí odkaz:
https://doaj.org/article/2391f0873e0f4a6a84d90aa514ecb5fb
Autor:
Hironobu YASUNO, Yasushi MASUDA, Harushige OZAKI, Tomoya SANO, Tadahiro SHINOZAWA, Takeshi WATANABE
Publikováno v:
Journal of Toxicologic Pathology.
Autor:
Harushige Ozaki
Publikováno v:
Folia Pharmacologica Japonica. 156:364-369
In vivo cardiovascular experiments as part of safety pharmacology studies have been developed for small molecule drug candidates to maximize detection power for potential undesirable pharmacodynamic effects of a drug candidate on physiological functi
Drug-induced convulsions-often caused by the inhibition of GABA receptors and stimulation of glutamate receptors-are difficult to predict in animals. In this study, we attempted to detect the proconvulsant potential using motor-evoked potentials (MEP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19084e21515d4db45d9fbb719591dbe6
Publikováno v:
Journal of pharmacological and toxicological methods. 112
Drug-induced convulsion is a severe adverse event; however, no useful biomarkers for it have been discovered. We propose a new method for predicting drug-induced convulsions in monkeys based on heart rate variability (HRV) and a machine learning tech
Autor:
Yukio Takahashi, Masahiro Bando, Tatsuya Jikuzono, Hiroshi Mizuno, Tomomichi Ishizaka, Jun Handa, Akihiro Kanno, Katsuyoshi Chiba, Harushige Ozaki, Akihito Ito, Tadashi Kakoi, Ryuichi Komatsu, Tadashi Koga
Publikováno v:
Journal of pharmacological and toxicological methods. 99
Introduction The preclinical in vivo assay for QT prolongation is critical for predicting torsadogenic risk, but still difficult to extrapolate to humans. This study ran preclinical tests in cynomolgus monkeys on seven QT reference drugs containing t
Autor:
Matthew Wagoner, Yoshiko Okai, Tadahiro Shinozawa, Keiko Matsune, Hiroshi Kohara, Emily Pfeiffer Kaushik, Kosuke Harada, Toshikatsu Matsui, Harushige Ozaki, Akimitsu Miyawaki, Kazunori Yamanaka
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 105:106893
Introduction Drug-induced inotropic change is a risk factor in drug development; thus, de-risking is desired in the early stages of drug development. Unlike proarrhythmic risk assessment using human induced pluripotent stem cell-derived cardiomyocyte
Autor:
Tatsuya Jikuzono, Tadashi Koga, Yukio Takahashi, Akihiro Kanno, Masahiro Bando, Harushige Ozaki, Tadashi Kakoi, Jun Handa, Katsuyoshi Chiba, Hiroshi Mizuno, Tomomichi Ishizaka, Akihito Ito, Ryuichi Komatsu
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 88:183-184
Autor:
Toshio Hashimoto, Yoshiyuki Motokawa, Katsuyoshi Chiba, Toshiki Kagawa, Kenta Watanabe, Kengo Sakamoto, Hisashi Nogawa, Jun Handa, Yukio Takahashi, Fuminori Matsubara, Akihiro Kanno, Harushige Ozaki, Ryouta Hayashi, Yuko Semi, Hiromi Negishi
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 88:184-185
Publikováno v:
Journal of Toxicologic Pathology. 11:33-40