Zobrazeno 1 - 10 of 271 pro vyhledávání: '"Haruo Sugi"'
1
Akademický článek
Tension Recovery following Ramp-Shaped Release in High-Ca and Low-Ca Rigor Muscle Fibers: Evidence for the Dynamic State of AMADP Myosin Heads in the Absence of ATP.
Autor: Haruo Sugi, Maki Yamaguchi, Tetsuo Ohno, Takakazu Kobayashi, Shigeru Chaen, Hiroshi Okuyama
Publikováno v: PLoS ONE, Vol 11, Iss 9, p e0162003 (2016)
During muscle contraction, myosin heads (M) bound to actin (A) perform power stroke associated with reaction, AMADPPi → AM + ADP + Pi. In this scheme, A • M is believed to be a high-affinity complex after removal of ATP. Biochemical studies on ex
Externí odkaz: https://doaj.org/article/c04639604dc449a2abafabc759811cbe
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2
Akademický článek
Definite differences between in vitro actin-myosin sliding and muscle contraction as revealed using antibodies to myosin head.
Autor: Haruo Sugi, Shigeru Chaen, Takakazu Kobayashi, Takahiro Abe, Kazushige Kimura, Yasutake Saeki, Yoshiki Ohnuki, Takuya Miyakawa, Masaru Tanokura, Seiryo Sugiura
Publikováno v: PLoS ONE, Vol 9, Iss 2, p e93272 (2014)
Muscle contraction results from attachment-detachment cycles between myosin heads extending from myosin filaments and actin filaments. It is generally believed that a myosin head first attaches to actin, undergoes conformational changes to produce fo
Externí odkaz: https://doaj.org/article/b660b70887ab47b89d8007d3e3edab4b
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3
Akademický článek
Enhancement of force generated by individual myosin heads in skinned rabbit psoas muscle fibers at low ionic strength.
Autor: Haruo Sugi, Takahiro Abe, Takakazu Kobayashi, Shigeru Chaen, Yoshiki Ohnuki, Yasutake Saeki, Seiryo Sugiura
Publikováno v: PLoS ONE, Vol 8, Iss 5, p e63658 (2013)
Although evidence has been presented that, at low ionic strength, myosin heads in relaxed skeletal muscle fibers form linkages with actin filaments, the effect of low ionic strength on contraction characteristics of Ca(2+)-activated muscle fibers has
Externí odkaz: https://doaj.org/article/7c08b0b84bc24eca8e460f59fd7e88b9
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4
Akademický článek
Dendritic cells pulsed with multifunctional Wilms’ tumor 1 (WT1) peptides combined with multiagent chemotherapy modulate the tumor microenvironment and enable conversion surgery in pancreatic cancer
Autor: Machi Suka, Hiroyuki Yanagisawa, Nobuhiro Sato, Shigetaka Shimodaira, Masayuki Saruta, Shigeo Koido, Junichi Taguchi, Masamori Shimabuku, Shin Kan, Tuuse Bito, Takeyuki Misawa, Zensho Ito, Kan Uchiyama, Shintaro Tsukinaga, Toshifumi Ohkusa, Haruo Sugiyama
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 12, Iss 10 (2024)
Background We aimed to develop a chemoimmunotherapy regimen consisting of a novel Wilms’ tumor 1 (WT1) peptide-pulsed dendritic cell (WT1-DC) vaccine and multiagent chemotherapy and to investigate the safety, clinical outcomes, and WT1-specific imm
Externí odkaz: https://doaj.org/article/3756c5f4da2747fd83b90f8049ea096a
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5
Akademický článek
Dendritic cell vaccination in combination with erlotinib in a patient with inoperable lung adenocarcinoma: a case report
Autor: Takuya Kosumi, Masanori Kobayashi, Shigetaka Shimodaira, Haruo Sugiyama, Shigeo Koido
Publikováno v: Journal of Medical Case Reports, Vol 18, Iss 1, Pp 1-6 (2024)
Abstract Background Satisfactory treatment for patients with unresectable advanced lung cancer has not yet been established. We report a case of unresectable advanced lung cancer (stage IIIb: T2aN3M0) treated with a total of 15 doses of dendritic cel
Externí odkaz: https://doaj.org/article/2a11a13b50cf4c7b849b3e9409165fe7
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6
X-ray Diffraction Studies on the Structural Origin of Dynamic Tension Recovery Following Ramp-Shaped Releases in High-Ca Rigor Muscle Fibers
Autor: Maki Yamaguchi, Haruo Sugi, Tetsuo Ohno, Hiroshi Okuyama, Naoto Yagi
Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 4, p 1244 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 4
It is generally believed that during muscle contraction, myosin heads (M) extending from myosin filament attaches to actin filaments (A) to perform power stroke, associated with the reaction, A-M-ADP-Pi &rarr
A-M + ADP + Pi, so that myosin heads
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b40eb99580a9775d16228d3ce9fb7c4
https://www.mdpi.com/1422-0067/21/4/1244
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8
Akademický článek
Enhancing the immunogenicity of Wilms tumor 1 epitope in mesothelioma cells with immunoproteasome inhibitors.
Autor: Masaki Ito, Shigeo Koido, Takeo Iwamoto, Soyoko Morimoto, Fumihiro Fujiki, Haruo Sugiyama, Saki Matsumoto, Clara Effenberger, Kazuma Kiyotani, Kiyotaka Shiba
Publikováno v: PLoS ONE, Vol 19, Iss 8, p e0308330 (2024)
The immunogenicity of cancer cells is influenced by several factors, including the expression of the major histocompatibility complex class I (MHC-I), antigen expression, and the repertoire of proteasome-produced epitope peptides. The malignant pleur
Externí odkaz: https://doaj.org/article/48eb8be2997a4476aa3cd46601614955
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10
Basic properties of ATP-induced myosin head movement in hydrated myosin filaments, studied using the gas environmental chamber
Autor: Haruo Sugi, Shigeru Chaen, Tsuyoshi Akimoto
Publikováno v: Micron (Oxford, England : 1993). 112
Although more than 50 years have passed since the monumental discovery of Huxley and Hanson that muscle contraction results from relative sliding between actin and myosin filaments, coupled with ATP hydrolysis, the mechanism underlying the filament s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edc19379068bf9d015e79675f4116032
https://pubmed.ncbi.nlm.nih.gov/29902615
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