Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Haruo, Nishimura"'
Autor:
Mitsuyo Shintani, Yoshihiro Ogawa, Kazuwa Nakao, Gen Inoue, Haruo Nishimura, Kiminori Hosoda, Shin Yonemitsu, Tatsuya Hayashi
Publikováno v:
Diabetes. 50:2296-2300
Thiazolidinediones, insulin-sensitizing agents, have been reported to increase glucose uptake along with the expression of glucose transporters in adipocytes and cardiomyocytes. Recently, we have further suggested that the translocation of GLUT4 is s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::021cdab8bd77ada3c7e9268316905753
https://doi.org/10.2337/diabetes.50.10.2296
https://doi.org/10.2337/diabetes.50.10.2296
Autor:
Yuji Yamamoto, Mitsuyo Shintani, Kazuwa Nakao, Ryou Inoue, Kiminori Hosoda, Hiroaki Masuzaki, Shin Yonemitsu, Haruo Nishimura, Gen Inoue, Tatsuya Hayashi, Yoshihiro Ogawa
Publikováno v:
Diabetes. 50:1093-1101
A number of studies have demonstrated that insulin resistance in the skeletal muscle plays a pivotal role in the insulin resistance associated with obesity and type 2 diabetes. A decrease in GLUT4 translocation from the intracellular pool to the plas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be163860411684316d76f8201de30f71
https://doi.org/10.2337/diabetes.50.5.1093
https://doi.org/10.2337/diabetes.50.5.1093
Autor:
Yasunao Yoshimasa, Hiroaki Masuzaki, Yoshihiko Watanabe, Junko Suga, Yoshihiro Ogawa, Yuji Yamamoto, Kiminori Hosoda, Kazuwa Nakao, Makoto Koh, Gen Inoue, Haruo Nishimura
Publikováno v:
Diabetes. 49:332-339
To address a role of mitogen-activated protein kinase (MAPK) in the regulation of glucose transport, we made a constitutively active mutant of MAPK kinase (MAPKK) and introduced it into 3T3-L1 preadipocytes by using a retrovirus-mediated transfection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a59ddcf3288bd3dc9c8a26ddbed2d06
https://doi.org/10.2337/diabetes.49.3.332
https://doi.org/10.2337/diabetes.49.3.332
Autor:
Hiroaki Masuzaki, Shin Yonemitsu, Yoshihiro Ogawa, Mitsuyo Shintani, Kazuwa Nakao, Gen Inoue, Yasunao Yoshimasa, Kiminori Hosoda, Haruo Nishimura
Publikováno v:
Metabolism. 49:326-330
Free fatty acid (FFA) has been reported to decrease leptin mRNA levels in 3T3-L1 adipocytes. When using this cell line, it is difficult to determine the protein levels because a very small amount of leptin is secreted into the medium. The effect of F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22a7098e5b1187f3aea25171058454f4
https://doi.org/10.1016/s0026-0495(00)90154-9
https://doi.org/10.1016/s0026-0495(00)90154-9
Autor:
Yoshihiro Ogawa, Shin Yonemitsu, Takashi Akamizu, Hiroaki Masuzaki, Gen Inoue, Haruo Nishimura, Kiminori Hosoda, Mitsuyo Shintani, Kazuwa Nakao, Yasunao Yoshimasa
Publikováno v:
Metabolism. 48:1570-1574
Leptin, which is secreted from adipocytes, has a role in the regulation of appetite and energy expenditure. The thyrotropin receptor (TSH-R) was recently found in adipocytes. We examined the effects of TSH on leptin production and lipolysis in rat ep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::069fe92b326cd133de7de25c6a23fb57
https://doi.org/10.1016/s0026-0495(99)90247-0
https://doi.org/10.1016/s0026-0495(99)90247-0
Increased glucose metabolism and insulin sensitivity in transgenic skinny mice overexpressing leptin
Autor:
Junko Suga, Megumi Aizawa-Abe, Hiroaki Masuzaki, Hidenori Iwai, Haruo Nishimura, Yukio Fujisawa, Ken Ebihara, Yoshihiro Ogawa, Yasunao Yoshimasa, Hisao Kasuga, Gen Inoue, Hiroyuki Odaka, Noriko Satoh, Michio Suda, Kiminori Hosoda, Kazuwa Nakao, Naoki Matsuoka
Publikováno v:
Diabetes. 48:1822-1829
Excess of body fat, or obesity, is a major health problem and confers a higher risk of cardiovascular and metabolic disorders such as diabetes, hypertension, and coronary heart disease. Leptin is an adipocyte-derived satiety factor that plays an impo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54f7c5b5351896d6ac3be164b8b11395
https://doi.org/10.2337/diabetes.48.9.1822
https://doi.org/10.2337/diabetes.48.9.1822
Autor:
Hiroaki Masuzaki, Megumi Aizawa-Abe, Gen Inoue, Haruo Nishimura, Ken Ebihara, Kazuwa Nakao, Hidenori Iwai, Kiminori Hosoda, Junko Suga, Yoshihiro Ogawa, Yasunao Yoshimasa, Noriko Satoh
Publikováno v:
Diabetes. 48:1615-1622
Leptin acts as an adipocyte-derived blood-borne satiety factor that can increase glucose metabolism. To elucidate the therapeutic implications of leptin for obesity-associated diabetes, we crossed transgenic skinny mice overexpressing leptin (Tg/+),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8757d4cd13f8fe8ef9803227a86b105b
https://doi.org/10.2337/diabetes.48.8.1615
https://doi.org/10.2337/diabetes.48.8.1615
Autor:
Mitsuyo Shintani, Gen Inoue, Mayumi Inoue, Naoya Sawada, Yasutomo Fukunaga, Tokuji Tanaka, Jun K. Yamashita, Kiminori Hosoda, Yasunao Yoshimasa, Kazuwa Nakao, Ken Masatsugu, Tae Hwa Chun, Takatoshi Saito, Haruo Nishimura, Hiroshi Itoh, Kentaro Doi
Publikováno v:
Diabetologia. 42:702-710
Aims/hypothesis. Previous studies show that inflammatory cytokines play a part in the development of insulin resistance. Thiazolidinediones were developed as insulin-sensitizing drugs and are ligands for the peroxisome proliferator-activated receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ac879ea8e5fb0609e0d46d63f119b04
https://doi.org/10.1007/s001250051218
https://doi.org/10.1007/s001250051218
Autor:
Tokuji Tanaka, Nobuyuki Azuma, Naoki Matsuoka, Toshio Igaki, Takaaki Yoshimasa, Yasunao Yoshimasa, Noriko Satoh, Kazuwa Nakao, Kiminori Hosoda, Junko Suga, Haruo Nishimura, Yuji Yamamoto, Hiroshi Itoh, Hiroaki Masuzaki, Michika Shigemoto, Shigeo Nishi, Yoshihiro Miyamoto
Publikováno v:
Metabolism. 47:456-460
It has been reported that the Trp 64 Arg mutation of the human beta3-adrenergic receptor (beta3-AR) gene is related to an earlier age of onset of non-insulin-dependent diabetes mellitus (NIDDM) and features of insulin resistance and weight gain in mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d3f461d281a55847920d9ef1f8fda6d
https://doi.org/10.1016/s0026-0495(98)90059-2
https://doi.org/10.1016/s0026-0495(98)90059-2
Autor:
Kazuwa Nakao, Takashi Miyawaki, Yoshihiro Ogawa, Nobuyuki Azuma, Haruo Nishimura, Koshi Natsui, Junichi Matsuda, S. Nishi, Kiminori Hosoda, Hiroaki Masuzaki, Naoki Matsuoka, Yasunao Yoshimasa, D. B. Thompson
Publikováno v:
Diabetologia. 40:1204-1210
Leptin is an adipocyte-derived blood-borne satiety factor that acts on its cognate leptin receptor (Ob-R) in the hypothalamus, thereby regulating food intake and energy expenditure. To explore whether mutations in the Ob-R gene cause obesity in human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd93e3bd9c02f121d1e2dfa4a5ebd8d2
https://doi.org/10.1007/s001250050808
https://doi.org/10.1007/s001250050808