Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Haruo, Horiai"'
Autor:
Yutaka Kohno, Takahiro Kusunoki, Haruo Horiai, Youichi Shiokawa, Yoshio Uehara, Atushi Akahane, Takao Terai, Keizo Yoshida, Yasuhiro Kita
Publikováno v:
Cardiovascular Drug Reviews. 15:44-58
Adenosine is a purine nucleotide that is widely distributed throughout the body; it modulates a wide variety of physiological functions via extracellular receptors. Adenosine receptors, located on the cell membranes, are classified into two major sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73869628acf9bfe86f0e01b00593ab26
https://doi.org/10.1111/j.1527-3466.1997.tb00323.x
https://doi.org/10.1111/j.1527-3466.1997.tb00323.x
Autor:
Yutaka Kohno, Haruo Horiai, Yasuhiro Kita, Keiko Nakano, Yasuhiro Mine, Noriko Nishina, Takao Terai, Keizo Yoshida, Takahiro Kusunoki
Publikováno v:
Drug Development Research. 39:47-53
The purpose of the present study was to examine the protective effect of FK453, (+)-(R)-1-[(E)-3-(2-phenylpyrazolo [1,5-a] pyridin-3-yl) acryloyl]-2-piperidine ethanol, a potent non-xanthine (adenosine A1 receptor antagonist, on glycerol-induced acut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85b371a86e30e408f63eea9b71aa8451
https://doi.org/10.1002/(sici)1098-2299(19960901)39:1<47::aid-ddr6>3.0.co
https://doi.org/10.1002/(sici)1098-2299(19960901)39:1<47::aid-ddr6>3.0.co
Autor:
Takeshi Andoh, Takao Terai, Yasuhiro Kita, Haruo Horiai, Atsushi Akahane, Takahiro Kusunoki, Youichi Shiokawa, Keizo Yoshida, Itzuo Nagatomi
Publikováno v:
Drug Development Research. 36:25-34
The renal effects of FK453, a potent and selective non-xanthine adenosine A 1 receptor antagonist, were examined and compared with FR113452 (less active enantiomer of FK453), typical adenosine receptor antagonists, and diuretics. In rats FK453 posses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62bef2dd289f65594e6f92d670e269a9
https://doi.org/10.1002/ddr.430360105
https://doi.org/10.1002/ddr.430360105
Autor:
Takaharu Ono, Miho Sato, Yoshihiko Sakata, Haruo Horiai, Jiro Seki, Yasuko Namikawa, Yukio Motoyama
Publikováno v:
Thrombosis Research. 65:55-63
TFC-612 inhibited thrombus formation on wire coils inserted into the lumen of the inferior vena cava of rats after 5 oral doses of 1.0 and 3.2 mg/kg and subcutaneous doses of 1.0 and 3.2 pg/rat/hr. This compound showed slight inhibition of platelet a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e9677847c9c39e8e68eca285e478315
https://doi.org/10.1016/0049-3848(92)90225-y
https://doi.org/10.1016/0049-3848(92)90225-y
Autor:
Jiro Seki, Yukio Motoyama, Takashi Asada, Yoshihiko Sakata, Haruo Horiai, Yasuko Namikawa, Takaharu Ono
Publikováno v:
Thrombosis Research. 63:29-38
The anti-platelet activities of TFC-612, methyl 6-(((1R, 2S, 3R)-3-hydroxy-2-((1E, 3S, 5R)-3-hydroxy-5-methyl-1-nonenyl)-5- oxocyclopentyl) thio)hexanoate, were compared to prostaglandin E1 (PGE1). TFC-612 inhibited human, guinea-pig and rabbit plate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c37fc4fd8654915682ac4b5fdf4807b5
https://doi.org/10.1016/0049-3848(91)90267-z
https://doi.org/10.1016/0049-3848(91)90267-z
Autor:
Takeshi, Inoue, Haruo, Horiai, Chizuru, Aoki, Ikuo, Kawamura, Mariko, Ota, Hidekazu, Mizuhara, Masaaki, Tomoi, Seitaro, Mutoh
Publikováno v:
In vivo (Athens, Greece). 17(3)
The aim of this study was to evaluate the effect of insulin-like growth factor-I (IGF-I) on lethality and liver function in experimental acute liver failure. Intravenous co-administration of D-galactosamine (GalN) and lipopolysaccharide (LPS) to rats
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d246852b6d487ac0fec4ac44ef66e77b
https://pubmed.ncbi.nlm.nih.gov/12929583
https://pubmed.ncbi.nlm.nih.gov/12929583
Autor:
Masako Hayashi, Hitoshi Sasaki, Yoshinori Ishii, Masakazu Kobayashi, Shingo Suzuki, Haruo Horiai, Takashi Asada, Joji Notani, Mineo Niwa, Fumio Shibayama, Yoshimasa Saito, Satoshi Koyama
Publikováno v:
Annals of the New York Academy of Sciences. 613:452-454
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a92ca8fcaf4521edd0e5d418b395deee
https://doi.org/10.1111/j.1749-6632.1990.tb18199.x
https://doi.org/10.1111/j.1749-6632.1990.tb18199.x
Autor:
Masako Hayashi, Mineo Niwa, Takao Fujimura, Yuko Imai, Haruo Horiai, Hitoshi Sasaki, Yoshinori Ishii, Masakazu Kobayashi, Yoshimasa Saito, Takashi Asada, Joji Notani, Sachiko Nakamura, Shingo Suzuki
Publikováno v:
Biotechnology progress. 10(5)
We have created a novel thrombolytic agent by the combination of mutation with partial deletion of tissue-type plasminogen activator (t-PA). We constructed Escherichia coli expression vectors for (i) native t-PA (nt-PA) and its derivatives; (ii) K1K2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::804360384ee38f97b58e5e94ee3fb748
https://pubmed.ncbi.nlm.nih.gov/7765373
https://pubmed.ncbi.nlm.nih.gov/7765373
Autor:
Kyoichi Shimomura, Fusako Nishigaki, Takahiro Kusunoki, Haruo Horiai, H. Minoura, K. Nakano, Toshitaka Manda, Y. Kotino, Takao Terai, M. Otsuka
Publikováno v:
Japanese Journal of Pharmacology. 67:317
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6aae524a683fb09f711b8de5b753fb30
https://doi.org/10.1016/s0021-5198(19)47234-x
https://doi.org/10.1016/s0021-5198(19)47234-x
Autor:
Yutaka Kohno, Minoru Ohtsuka, Masahiro Takeda, Kimio Esumi, Haruo Horiai, Kyoichi Shimomura, Masashi Imai
Publikováno v:
Japanese Journal of Pharmacology. 64:176
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::157aae07744e53ea5f7e6c025d3d1ca7
https://doi.org/10.1016/s0021-5198(19)50348-1
https://doi.org/10.1016/s0021-5198(19)50348-1