Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Haruna Sakurai"'
Autor:
Hiroshi Kawai, Takuo Suzuki, Tetsu Kobayashi, Akiko Ishii-Watabe, Haruna Sakurai, Hisayuki Ohata, Kazuo Honda, Kazutaka Momose, Takao Hayakawa, Toru Kawanishi
Publikováno v:
Journal of Pharmacological Sciences, Vol 103, Iss 2, Pp 159-167 (2007)
The caspase activation cascade and mitochondrial changes are major biochemical reactions in the apoptotic cell death machinery. We attempted to clarify the temporal relationship between caspase activation, cytochrome c release, mitochondrial depolari
Externí odkaz:
https://doaj.org/article/5204b19b73cb489da5b4d138021a2fec
Autor:
Hiroshi Kawai, Takuo Suzuki, Tetsu Kobayashi, Haruna Sakurai, Hisayuki Ohata, Kazuo Honda, Kazutaka Momose, Iyuki Namekata, Hikaru Tanaka, Koki Shigenobu, Ryu Nakamura, Takao Hayakawa, Toru Kawanishi
Publikováno v:
Journal of Pharmacological Sciences, Vol 97, Iss 3, Pp 361-368 (2005)
Fluorescence resonance energy transfer (FRET) with green fluorescent protein (GFP) variants has become widely used for biochemical research. In order to expand the choice of fluorescent range in FRET analysis, we designed various color versions of th
Externí odkaz:
https://doaj.org/article/43d6ebd1e59c4a6f8f9eec54544820e9
Autor:
Hirotaka Ojima, Libo Zhou, Jun Shimizu, Naohiko Yano, Haruna Sakurai, Teppei Onuki, Takeyuki Yamamoto
Publikováno v:
The Proceedings of Ibaraki District Conference. :714
Autor:
Haruna Sakurai
Publikováno v:
YAKUGAKU ZASSHI. 131:1461-1464
RecQ5 belongs to the family of RecQ DNA helicases. There are 5 RecQ homologs in mammals, and defects in 3 of them (BLM, WRN, and RECQL4) give rise to cancer predisposition syndromes in humans. Although no human disease has yet been genetically linked
Publikováno v:
FEBS Letters. 585:1923-1928
Drosophila melanogaster RecQ5, a member of the RecQ family, is expressed in early embryos. The loss of maternally-derived RecQ5 leads to spontaneous mitotic defects in syncytial embryos. We demonstrate that the mitotic defects are derived from anapha
Autor:
Takao Hayakawa, Haruna Sakurai, Hiroyuki Mizuguchi, Asami Kondo, Kenji Kawabata, Koichi Yamanishi, Katsuhisa Tashiro, Fuminori Sakurai
Publikováno v:
Biochemical and Biophysical Research Communications. 379:127-132
Bone marrow stromal cells (BMSCs) are expected to be a source for tissue regeneration because they can differentiate into multiple cell types. Establishment of efficient gene transfer systems for BMSCs is essential for their application to regenerati
Publikováno v:
International Journal of Pharmaceutics. 354:9-15
Gene therapy is a clinical strategy that has the potential to treat an array of genetic and nongenetic diseases. Vectors for gene transfer are the essential tools of gene therapy. For gene therapy to be successful, an appropriate amount of the therap
Autor:
Kenji Kawabata, Katsuhisa Tashiro, Naoya Koizumi, Hiroyuki Mizuguchi, Fuminori Sakurai, Haruna Sakurai, Shinnosuke Kurachi, Shinsaku Nakagawa
Publikováno v:
Journal of Controlled Release. 127:88-95
Adenovirus (Ad) vector application in gene therapy is limited by its naïve tropism. We previously developed protein IX (pIX)-modified and hexon-modified Ad vectors in order to alter Ad vector tropism. However, these modified Ad vectors failed to inf
Autor:
K Yayama, Hiroyuki Mizuguchi, Shinnosuke Kurachi, Haruna Sakurai, Katsuhisa Tashiro, Shinsaku Nakagawa, Kenji Kawabata, H Okamoto, Fuminori Sakurai
Publikováno v:
Gene Therapy. 14:1160-1165
The interaction between viral capsid proteins and specific molecules exposed on the plasma membrane of the cells is involved in the viral tropism. A human adenovirus (Ad) belonging to subgroups A, C, D, E and F infects cells via the interaction betwe
Autor:
Kazutaka Momose, Takuo Suzuki, Haruna Sakurai, Hisayuki Ohata, Tetsu Kobayashi, Kazuo Honda, Akiko Ishii-Watabe, Hiroshi Kawai, Takao Hayakawa, Toru Kawanishi
Publikováno v:
Journal of Pharmacological Sciences, Vol 103, Iss 2, Pp 159-167 (2007)
The caspase activation cascade and mitochondrial changes are major biochemical reactions in the apoptotic cell death machinery. We attempted to clarify the temporal relationship between caspase activation, cytochrome c release, mitochondrial depolari