Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Haruna Otsuka"'
Autor:
Takumi Itoh, Ryo Hatano, Yoshiya Horimoto, Taketo Yamada, Dan Song, Haruna Otsuka, Yuki Shirakawa, Shuji Mastuoka, Noriaki Iwao, Thomas M. Aune, Nam H. Dang, Yutaro Kaneko, Ko Okumura, Chikao Morimoto, Kei Ohnuma
Publikováno v:
Cell Death and Disease, Vol 12, Iss 6, Pp 1-17 (2021)
Abstract Triple-negative breast cancer (TNBC) has a poor prognosis compared to other breast cancer subtypes. Although epidermal growth factor receptor (EGFR) is overexpressed in TNBC, clinical trials with EGFR inhibitors including tyrosine kinase inh
Externí odkaz:
https://doaj.org/article/56e668697c254208a1ec8f6af7dc9a5a
Autor:
Ryo Hatano, Taketo Yamada, Hiroko Madokoro, Haruna Otsuka, Eriko Komiya, Takumi Itoh, Yuka Narita, Satoshi Iwata, Hiroto Yamazaki, Shuji Matsuoka, Nam H Dang, Kei Ohnuma, Chikao Morimoto
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0218330 (2019)
A 110-kDa type II transmembrane glycoprotein with dipeptidyl peptidase IV (DPPIV) activity in its extracellular region, CD26 has a multitude of biological functions and plays an important role in the regulation of inflammatory responses and tumor bio
Externí odkaz:
https://doaj.org/article/ea5881151b604172bb871051858118e6
Autor:
Ryo Hatano, Takumi Itoh, Haruna Otsuka, Harumi Saeki, Ayako Yamamoto, Dan Song, Yuki Shirakawa, Satoshi Iyama, Tsutomu Sato, Noriaki Iwao, Norihiro Harada, Thomas M. Aune, Nam H. Dang, Yutaro Kaneko, Taketo Yamada, Chikao Morimoto, Kei Ohnuma
Publikováno v:
American Journal of Transplantation. 22:2804-2820
IL-26 is a Th17 cytokine, with its gene being absent in rodents. To characterize the in vivo immunological effects of IL-26 in chronic systemic inflammation, we used human IL26 transgenic (hIL-26Tg) mice and human umbilical cord blood mononuclear cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63a071c234f77d496bca2fa1e08870f9
https://doi.org/10.1111/ajt.17178
https://doi.org/10.1111/ajt.17178
Autor:
Thomas M. Aune, Satoshi Iwata, Nam H. Dang, Kyoko Kuwahara-Arai, Ryo Hatano, Takumi Itoh, Sayo Okamoto, Eriko Komiya, Chikao Morimoto, Kei Ohnuma, Haruna Otsuka
Publikováno v:
MAbs
Interleukin (IL)-26, known as a Th17 cytokine, acts on various cell types and has multiple biological functions. Although its precise role still remains to be elucidated, IL-26 is suggested to be associated with the pathology of diverse chronic infla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbd3b4b6518ed3eda35b5d0652fe8119
https://pubmed.ncbi.nlm.nih.gov/31397631
https://pubmed.ncbi.nlm.nih.gov/31397631
Autor:
Hiroto Yamazaki, Takumi Itoh, Ryo Hatano, Haruna Otsuka, Satoshi Iwata, Nam H. Dang, Shuji Matsuoka, Taketo Yamada, Chikao Morimoto, Eriko Komiya, Hiroko Madokoro, Yuka Narita, Kei Ohnuma
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 6, p e0218330 (2019)
PLoS ONE, Vol 14, Iss 6, p e0218330 (2019)
A 110-kDa type II transmembrane glycoprotein with dipeptidyl peptidase IV (DPPIV) activity in its extracellular region, CD26 has a multitude of biological functions and plays an important role in the regulation of inflammatory responses and tumor bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90098a8f61a40822c7e5dba1ff04689a
http://europepmc.org/articles/PMC6564021
http://europepmc.org/articles/PMC6564021
Autor:
Mitsutoshi Tominaga, Chikao Morimoto, Kenji Takamori, Hisashi Naito, Shuji Matsuoka, Haruna Otsuka, Thomas M. Aune, Nam H. Dang, Ryo Hatano, Takumi Itoh, Kei Ohnuma, Yuka Narita, Eriko Komiya
Publikováno v:
The Journal of investigative dermatology. 139(4)
Psoriasis is a chronic inflammatory skin disease characterized mainly by epidermal hyperplasia, scaling, and erythema; T helper 17 cells have a role in its pathogenesis. Although IL-26, known as a T helper 17 cytokine, is upregulated in psoriatic ski
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca2ee0b3e660914c9fffcba3c95f9f7c
https://pubmed.ncbi.nlm.nih.gov/30423328
https://pubmed.ncbi.nlm.nih.gov/30423328
Autor:
Kei Ohnuma, Haruna Otsuka, Nam H. Dang, Ryo Hatano, Noriaki Iwao, Taketo Yamada, Chikao Morimoto, Eriko Komiya, Yutaro Kaneko, Takumi Itoh
Publikováno v:
Frontiers in bioscience (Landmark edition). 23(9)
CD26 is a 110 kDa surface glycoprotein with intrinsic dipeptidyl peptidase IV activity that is expressed on numerous cell types and has a multitude of biological functions. The role of CD26 in immune regulation has been extensively characterized, wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6013e4edf2c3ecd266b10d303adb5184
https://pubmed.ncbi.nlm.nih.gov/29772527
https://pubmed.ncbi.nlm.nih.gov/29772527
Autor:
Utako Kimura, Eriko Komiya, Kenji Takamori, Kei Ohnuma, Yasushi Suga, Nam H. Dang, Ryo Hatano, Hiroto Yamazaki, Haruna Otsuka, Takumi Itoh, Mitsutoshi Tominaga, Taketo Yamada, Chikao Morimoto
Publikováno v:
Journal of dermatological science. 86(3)
Background Psoriasis (PSO) is one of the most common chronic inflammatory skin diseases, and pruritus affects approximately 60–90% of patients with PSO. However, the pathogenesis of pruritus in PSO remains unclear. Dipeptidyl peptidase IV (DPPIV) e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e05005461476096daa1672d6cf222eb3
https://pubmed.ncbi.nlm.nih.gov/28365081
https://pubmed.ncbi.nlm.nih.gov/28365081
Autor:
Taketo Yamada, Chikao Morimoto, Eriko Komiya, Kenji Takamori, Kei Ohnuma, Ryo Hatano, Mitsutoshi Tominaga, Takumi Itoh, Haruna Otsuka
Publikováno v:
Journal of Dermatological Science. 86:e7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44504af15732733284659d8c69eb83cc
https://doi.org/10.1016/j.jdermsci.2017.02.019
https://doi.org/10.1016/j.jdermsci.2017.02.019
Autor:
Satoshi Iwata, Izumi Taki, Haruna Otsuka, Chikao Morimoto, Ko Okumura, Nam H. Dang, Ryo Hatano, Eriko Komiya, Kei Ohnuma
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 194(3)
CD26 is associated with T cell signal transduction processes as a costimulatory molecule, and CD26+ T cells have been suggested to be involved in the pathophysiology of diverse autoimmune diseases. Although the cellular and molecular mechanisms invol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64917ff40c9a3f949c5ff88427136937
https://pubmed.ncbi.nlm.nih.gov/25548232
https://pubmed.ncbi.nlm.nih.gov/25548232