Výsledky vyhledávání - "Haruna Nagumo"

Human PBMC-transferred murine MHC class I/II-deficient NOG mice enable long-term evaluation of human immune responses

Autor: Takashi Inozume, Takashi Iwata, Ryoji Ito, Yutaka Kawakami, Asuka Kobayashi, Ikumi Katano, Haruna Nagumo, Tomonori Yaguchi, Kenji Morii, Yuyo Ka, Mamoru Ito, Hiroshi Nishio

Publikováno v: Cellular & Molecular Immunology

Immunodeficient mice engrafted with human peripheral blood cells are promising tools for in vivo analysis of human patient individual immune responses. However, when human peripheral blood mononuclear cells (PBMCs) are transferred into NOG (NOD/Shi-s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::398c2e7282d4198e6a1a9acd126cb3a8
https://doi.org/10.1038/cmi.2017.106

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Determination of poor prognostic immune features of tumour microenvironment in non-smoking patients with lung adenocarcinoma

Publikováno v: European Journal of Cancer. 86:15-27

We have previously demonstrated that the prognostic significance of tumour-infiltrating CD8+ T cells significantly differs according to histological type and patient smoking habits in non-small cell lung cancer (NSCLC). This work suggested that infil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b22872a5a046aad9acb3860ad46284cd
https://doi.org/10.1016/j.ejca.2017.08.026

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Prognostic value of tumor-infiltrating lymphocytes differs depending on histological type and smoking habit in completely resected non-small-cell lung cancer

Autor: Ikuo Kamiyama, Hisao Asamura, Tomonobu Fujita, Takashi Ohtsuka, Takehisa Sakurai, R. Muramatsu, Tomonori Yaguchi, Haruna Nagumo, Yutaka Kawakami, Yuichiro Hayashi, Nobuo Tsukamoto, Chie Kudo-Saito, Tomonari Kinoshita, E. Takahata, Shinobu Noji

Publikováno v: Annals of oncology : official journal of the European Society for Medical Oncology. 27(11)

Background T-cell infiltration in tumors has been used as a prognostic tool in non-small-cell lung cancer (NSCLC). However, the influence of smoking habit and histological type on tumor-infiltrating lymphocytes (TILs) in NSCLC remains unclear. Patien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc42668a5be1d811bd039acdf3831a16
https://pubmed.ncbi.nlm.nih.gov/27502728

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Personalized Cancer Immunotherapy: Immune Biomarkers and Combination Immunotherapy

Publikováno v: Immunotherapy of Cancer ISBN: 9784431550303

Cancer immunotherapies utilizing tumor-specific T-cell responses, immune-checkpoint blockade, and T-cell-based adoptive cell therapy, have recently shown durable responses in advanced patients with various cancers. However, there are still cancer typ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ef52d4f2072799124265b06187c1c60
https://doi.org/10.1007/978-4-431-55031-0_24

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Development of Personalized Combination Cancer Immunotherapy Based on the Patients’ Immune Status

Publikováno v: Inflammation and Immunity in Cancer ISBN: 9784431553267

Cancer immunotherapies, particularly immune-checkpoint blockade and T cell-based adoptive cell therapy, have recently been recognized as cancer treatments that show strong and durable responses even for advanced cancer patients with multiple metastas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::43ac882dd444b3b10cf9642b049b31e2
https://doi.org/10.1007/978-4-431-55327-4_20

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The presence of phorbol ester responsive and non-responsive forms of the ζ isozyme of protein kinase C in mouse epidermal cells

Autor: Satoshi Yamamoto, Kouichi Maruyama, Ryuichi Kato, Kiyotaka Nishikawa, Haruna Nagumo

Publikováno v: Cellular Signalling. 7:491-504

The possible involvement of zeta isozyme of protein kinase C (PKC zeta) in phorbol ester-induced signal transduction was investigated in mouse epidermal cells. Western blot analysis of RESOURCE Q column chromatography eluates obtained from 105,000 g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8f77f46f2f1ddaa357f54ca8f897661
https://doi.org/10.1016/0898-6568(95)00019-l

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Induction of protein kinase Czeta-related protein kinase by growth suppression in carcinogen-initiated epidermal cell-line WYF31 cells

Autor: Junken Aoki, Hisamitsu Sameda, Ryuichi Kato, Hiroyuki Arai, Keizo Inoue, Jian Chun Wang, Kiyotaka Nishikawa, Yasuhiko Tsuzuki, Haruna Nagumo, Satoshi Yamamoto, Hiroyasu Kudo

Publikováno v: Cellular signalling. 12(1)

In primary cultured mouse epidermal cells, protein kinase C isozyme zeta (PKCzeta) consists of multiple forms, for example, low-salt eluted PKCzeta (1-PKCzeta; 79 and 85 kDa) and high-salt eluted PKCzeta (h-PKCzeta; 79 and 85 kDa) on anion-exchange c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaa35298ccfec3b13327e00471808ec6
https://pubmed.ncbi.nlm.nih.gov/10676843

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KP-10, a novel protein kinase C substrate in intact mouse epidermal cells, is phosphorylated by novel protein kinase C eta and/or zeta

Autor: Norie Murayama, Kiyotaka Nishikawa, Motoko Ishihara, Haruna Nagumo, Satoshi Yamamoto, Ryuichi Kato

Publikováno v: Cellular signalling. 6(5)

Recently this group found an endogenous substrate protein for Ca(2+)-independent novel protein kinase C (nPKC), i.e. KP-10 (pI 4.7/25,500 M(r)), in primary cultured mouse epidermal cells [Nishikawa, K. et al. (1992) Cell. Signal. 4, 757-776]. In the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9958f618ce5f1dc3dc26843c6a4a778f
https://pubmed.ncbi.nlm.nih.gov/7818986

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