Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Haruna Nagayoshi"'
Autor:
Tsutomu Shimada, Haruna Nagayoshi, Norie Murayama, Atsuki Sawai, Vitchan Kim, Donghak Kim, Hiroshi Yamazaki, F. Peter Guengerich, Shigeo Takenaka
Publikováno v:
Xenobiotica
1. Oxidation of 3′-methoxyflavone, 4′-methoxyflavone, and 3′,4′-dimethoxyflavone and their derivatives containing 5,7-dihydroxyl groups by human cytochrome P450 (P450 or CYP) 1B1 and 2A13 was determined using LC-MS/MS systems. 2. 3′-Methoxy
Autor:
Donghak Kim, F. Peter Guengerich, Shigeo Takenaka, Norie Murayama, Masayuki Komori, Tsutomu Shimada, Hiroshi Yamazaki, Vitchan Kim, Haruna Nagayoshi
Publikováno v:
Xenobiotica
1. Nine forms of recombinant cytochrome P450 (P450 or CYP) enzymes were used to study roles of individual P450 enzymes in the oxidation of flavone and some other flavonoids, 4´-hydroxyflavone and 4´-, 3´-, and 2´-methoxyflavones, by human liver m
Autor:
Vitchan Kim, Tsutomu Shimada, Norie Murayama, Masayuki Komori, Donghak Kim, F. Peter Guengerich, Hiroshi Yamazaki, Shigeo Takenaka, Jun Katahira, Haruna Nagayoshi
Publikováno v:
Xenobiotica
2′-Hydroxyflavanone (2′OHFva), 3′OHFva, 4′OHFva, and 6OHFva, the major oxidative products of flavanone by human cytochrome P450 (P450, CYP) enzymes, were studied in regard to further oxidation by human CYP1A1, 1A2, 1B1.1, 1B1.3, and 2A6. The
Autor:
Tsutomu Shimada, Donghak Kim, Vitchan Kim, Norie Murayama, Masayuki Komori, Masaki Tsujino, Haruna Nagayoshi, Shigeo Takenaka, Jun Katahira, Hiroshi Yamazaki, F. Peter Guengerich
Publikováno v:
Xenobiotica. 50:1158-1169
2′-, 3′-, and 4′-Methoxyflavones (MeFs) were incubated with nine forms of recombinant human cytochrome P450 (P450 or CYP) enzymes in the presence of an NADPH-generating system and the products form...
Autor:
Takashi Kuramoto, Masahide Asano, Yukihiro Ohno, Ai Nishitani, Shigeo Takenaka, Saki Shimizu, Haruna Nagayoshi
Publikováno v:
Experimental Animals. 69:388-394
We recently demonstrated that aspartoacylase (Aspa) and hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 (Hcn1) genes were causative of essential tremor (ET) in rats. This finding was obtained using Aspaem34Kyo/Hcn1A354V double
Autor:
Ai, Nishitani, Haruna, Nagayoshi, Shigeo, Takenaka, Masahide, Asano, Saki, Shimizu, Yukihiro, Ohno, Takashi, Kuramoto
Publikováno v:
Experimental Animals
We recently demonstrated that aspartoacylase (Aspa) and hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 (Hcn1) genes were causative of essential tremor (ET) in rats. This finding was obtained using Aspaem34Kyo/Hcn1A354V double
Autor:
Haruna, Nagayoshi, Norie, Murayama, Masaki, Tsujino, Shigeo, Takenaka, Jun, Katahira, Vitchan, Kim, Donghak, Kim, Masayuki, Komori, Hiroshi, Yamazaki, F Peter, Guengerich, Tsutomu, Shimada
Publikováno v:
Xenobiotica
1. 2′-, 3′-, and 4′-Methoxyflavones (MeFs) were incubated with nine forms of recombinant human cytochrome P450 (P450 or CYP) enzymes in the presence of an NADPH-generating system and the products formed were analyzed with LC-MS/MS methods. 2. C
Autor:
Young-Ran Lim, Vitchan Kim, Haruna Nagayoshi, Donghak Kim, Tsutomu Shimada, F. Peter Guengerich, Shigeo Takenaka, Kensaku Kakimoto, Jun Katahira, Masayuki Komori, Hiroshi Yamazaki, Norie Murayama
Publikováno v:
Xenobiotica. 49:791-802
The roles of human cytochrome P450 (P450 or CYP) 2A6 in the oxidation of flavanone [(2R)- and (2S)-enantiomers] and flavone were studied in human liver microsomes and recombinant human P450 enzymes.CYP2A6 was highly active in oxidizing flavanone to f
Autor:
F. Peter Guengerich, Tsutomu Shimada, Haruna Nagayoshi, Young-Ran Lim, Shigeo Takenaka, Masayuki Komori, Vitchan Kim, Hiroshi Yamazaki, Donghak Kim, Kensaku Kakimoto, Norie Murayama
Publikováno v:
Xenobiotica. 49:131-142
1. We previously reported that flavone and flavanone interact spectrally with cytochrome P450 (P450 or CYP) 2A6 and 2A13 and other human P450s and inhibit catalytic activities of these P450 enzymes. In this study, we studied abilities of CYP1A1, 1A2,
Autor:
Yoshimasa Konishi, Akira Toriba, Fumio Matsumoto, Kazuichi Hayakawa, Naomi Tsukue, Haruna Nagayoshi, Ning Tang, Takeshi Nakano, Kensaku Kakimoto, Keiji Kajimura, Kazuhiko Akutsu, Tomoo Yoshino
Publikováno v:
Ecotoxicology and Environmental Safety. 147:367-372
The red-crowned crane ( Grus japonensis ) from eastern Hokkaido is classified as a Special Natural Monument in Japan. In this study, we determined the concentrations of persistent organic pollutants (POPs) in red-crowned crane muscle tissues (n = 47)