Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Haruna Ebisu"'
Publikováno v:
BMJ Open, Vol 14, Iss 6 (2024)
Introduction Insomnia is a common health problem and cognitive–behavioural therapy (CBT) is recommended as a treatment. As there is a critical shortage of CBT-trained therapists, we developed a digital CBT application (IIIP MED: Sleepy Med) as Soft
Externí odkaz:
https://doaj.org/article/beac7e8a89934267a15b2e123ee6b94c
Autor:
Haruna Ebisu, Kana Shintani, Takumi Chinen, Yoko Nagumo, Shuya Shioda, Taisei Hatanaka, Akira Sakakura, Ichiro Hayakawa, Hideo Kigoshi, Takeo Usui
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2021)
α/β-Tubulin inhibitors that alter microtubule (MT) dynamics are commonly used in cancer therapy, however, these inhibitors also cause severe side effects such as peripheral neuropathy. γ-Tubulin is a possible target as antitumor drugs with low sid
Externí odkaz:
https://doaj.org/article/538758ef14db4b708215884f46c3aa3d
Autor:
Haruna Ebisu, Taisei Hatanaka, Ichiro Hayakawa, Daisuke Takao, Kana Shintani, Yoko Nagumo, Takumi Chinen, Takeo Usui, Minagi Mukaiyama, Akira Sakakura
Publikováno v:
ACS Med Chem Lett
[Image: see text] Gatastatin (O(7)-benzyl glaziovianin A) is a γ-tubulin-specific inhibitor that is used to investigate γ-tubulin function in cells. We have previously reported that the unsubstituted phenyl ring of the O(7)-benzyl group in gatastat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::410c4dfb2e2059677e6df2e35b5cc53f
https://pubmed.ncbi.nlm.nih.gov/32550991
https://pubmed.ncbi.nlm.nih.gov/32550991
Autor:
Ichiro Hayakawa, Shuya Shioda, Takumi Chinen, Hideo Kigoshi, Takeo Usui, Akira Sakakura, Haruna Ebisu, Taisei Hatanaka
Publikováno v:
Bioorganic & Medicinal Chemistry. 24:5639-5645
We have discovered O6-benzyl glaziovianin A, which showed stronger inhibition of microtubule polymerization (IC50 = 2.1 μM) than known α,β-tubulin inhibitors, such as colchicine and glaziovianin A. Also, we performed competition binding experiment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f99350f86169976da717630c6b510b5e
https://doi.org/10.1016/j.bmc.2016.09.026
https://doi.org/10.1016/j.bmc.2016.09.026
Autor:
Shun Ichiro Uesugi, Takamichi Imaizumi, Tsubasa Watanabe, Masatoshi Shibuya, Yu Ota, Yoko Nagumo, Takumi Chinen, Takeo Usui, Keisuke Yoshida, Haruna Ebisu, Yoshiharu Iwabuchi, Naoki Kanoh
Publikováno v:
The Journal of Organic Chemistry. 80:12333-12350
Irciniastatin A (a.k.a. psymberin) and irciniastatin B are members of the pederin natural product family, which have potent antitumor activity and structural complexity. Herein, we describe a full account of our total synthesis of (+)-irciniastatin A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28fb1d269437a6cf50ca6e48e9e6c487
https://doi.org/10.1021/acs.joc.5b02256
https://doi.org/10.1021/acs.joc.5b02256
Autor:
Ichiro, Hayakawa, Shuya, Shioda, Takumi, Chinen, Taisei, Hatanaka, Haruna, Ebisu, Akira, Sakakura, Takeo, Usui, Hideo, Kigoshi
Publikováno v:
Bioorganicmedicinal chemistry. 24(21)
We have discovered O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d1a83964b7a77270c43586f7f01eebfc
https://pubmed.ncbi.nlm.nih.gov/27665177
https://pubmed.ncbi.nlm.nih.gov/27665177