Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Harumi Nakao"'
Autor:
Toshiya Matsukawa, Takashi Yagi, Tohru Uchida, Mashito Sakai, Masaru Mitsushima, Takao Naganuma, Hiroyuki Yano, Yuka Inaba, Hiroshi Inoue, Keisuke Yanagida, Masaaki Uematsu, Kazuki Nakao, Harumi Nakao, Atsu Aiba, Yoji Nagashima, Tetsuya Kubota, Naoto Kubota, Yoshihiko Izumida, Naoya Yahagi, Hiroyuki Unoki-Kubota, Yasushi Kaburagi, Shun-ichiro Asahara, Yoshiaki Kido, Hideo Shindou, Michiko Itoh, Yoshihiro Ogawa, Shiro Minami, Yasuo Terauchi, Kazuyuki Tobe, Kohjiro Ueki, Masato Kasuga, Michihiro Matsumoto
Publikováno v:
JCI Insight, Vol 8, Iss 17 (2023)
Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes are interacting comorbidities of obesity, and increased hepatic de novo lipogenesis (DNL), driven by hyperinsulinemia and carbohydrate overload, contributes to their pathogenesis. Fatty aci
Externí odkaz:
https://doaj.org/article/e5ab1c9c4a954f56823c71beefd37326
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract Genetic engineering of non-human primates, which are most closely related to humans, has been expected to generate ideal animal models for human genetic diseases. The common marmoset (Callithrix jacchus) is a non-human primate species adequa
Externí odkaz:
https://doaj.org/article/16bd25af222946dd8e654cb9a9d2af38
Autor:
Yuta Hiraike, Shuichi Tsutsumi, Takahito Wada, Misato Oguchi, Kaede Saito, Masahiro Nakamura, Satoshi Ota, Michinori Koebis, Harumi Nakao, Atsu Aiba, Gaku Nagano, Haruya Ohno, Kenji Oki, Masayasu Yoneda, Takashi Kadowaki, Hiroyuki Aburatani, Hironori Waki, Toshimasa Yamauchi
Publikováno v:
iScience, Vol 25, Iss 8, Pp 104729- (2022)
Summary: Thermogenic brown and beige adipocytes counteract obesity by enhancing energy dissipation via uncoupling protein-1 (Ucp1). However, the effect of genetic variation on these cells, a major source of disease susceptibility, has been less well
Externí odkaz:
https://doaj.org/article/01de9396aecc4b60a77d354c4c154676
Autor:
Maria Harbers, Harumi Nakao, Takaki Watanabe, Kyoko Matsuyama, Shoichi Tohyama, Kazuki Nakao, Yasushi Kishimoto, Masanobu Kano, Atsu Aiba
Publikováno v:
Cells, Vol 11, Iss 13, p 2004 (2022)
Group I metabotropic glutamate receptors (mGluRs) include mGluR1 and mGluR5, which are coupled to the Gq family of heterotrimeric G-proteins and readily activated by their selective agonist 3,5-dihydroxyphenilglycine (DHPG). mGluR1 and mGluR5 exhibit
Externí odkaz:
https://doaj.org/article/addd30c62fbf4d849ca120dfa65d33c9
Autor:
Yuta, Hiraike, Shuichi, Tsutsumi, Takahito, Wada, Misato, Oguchi, Kaede, Saito, Masahiro, Nakamura, Satoshi, Ota, Michinori, Koebis, Harumi, Nakao, Atsu, Aiba, Gaku, Nagano, Haruya, Ohno, Kenji, Oki, Masayasu, Yoneda, Takashi, Kadowaki, Hiroyuki, Aburatani, Hironori, Waki, Toshimasa, Yamauchi
Publikováno v:
iScience. 25(8)
Thermogenic brown and beige adipocytes counteract obesity by enhancing energy dissipation via uncoupling protein-1 (Ucp1). However, the effect of genetic variation on these cells, a major source of disease susceptibility, has been less well studied.
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Genetic engineering of non-human primates, which are most closely related to humans, has been expected to generate ideal animal models for human genetic diseases. The common marmoset (Callithrix jacchus) is a non-human primate species adequate for th
Autor:
Yuta Hiraike, Shuichi Tsutsumi, Takahito Wada, Misato Oguchi, Kaede Saito, Masahiro Nakamura, Satoshi Ota, Michinori Koebis, Harumi Nakao, Atsu Aiba, Gaku Nagano, Haruya Ohno, Kenji Oki, Masayasu Yoneda, Takashi Kadowaki, Hiroyuki Aburatani, Hironori Waki, Toshimasa Yamauchi
Publikováno v:
iScience. 25:104729
Autor:
Yasushi Kishimoto, Kouichi Hashimoto, Kazuo Kitamura, Yutaka Kirino, Masahiko Watanabe, Kazuki Nakao, Harumi Nakao, Miwako Yamasaki, Atsu Aiba, Masanobu Kano
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports
Scientific Reports
Classical eyeblink conditioning is a representative associative motor learning that requires both the cerebellar cortex and the deep cerebellar nucleus (DCN). Metabotropic glutamate receptor subtype 1 (mGluR1) is richly expressed in Purkinje cells (P
Autor:
Harumi Nakao, Hiroshi Kiyonari, Kenichi Inoue, Takeshi Harada, Kazuki Nakao, Atsu Aiba, Yasuhide Furuta
Publikováno v:
genesis. 54:65-77
The CRISPR/Cas system has rapidly emerged recently as a new tool for genome engineering, and is expected to allow for controlled manipulation of specific genomic elements in a variety of species. A number of recent studies have reported the use of CR
Autor:
Ferdinando Nicoletti, Giorgio Carmignoto, Roberto Gradini, Serena Notartomaso, Valeria Bruno, Francesca Liberatore, Masahiko Watanabe, Cristina Zappulla, Atsu Aiba, Marta Motolese, Milena Cannella, Giuseppe Battaglia, Pamela Scarselli, Michele Madonna, Harumi Nakao, Giada Mascio, Micaela Zonta
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Scientific Reports
Scientific Reports
In cerebellar Purkinje cells (PCs) type-1 metabotropic glutamate (mGlu1) receptors play a key role in motor learning and drive the refinement of synaptic innervation during postnatal development. The cognate mGlu5 receptor is absent in mature PCs and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10238ca0cdf1cb4ca618fd7e9e2ccc81
http://hdl.handle.net/11573/1177286
http://hdl.handle.net/11573/1177286