Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Harumi Matsuda"'
Publikováno v:
Blucher Design Proceedings.
Autor:
Atsushi Kitamura, Atsushi Suwa, Mutsuko Sakai, Takeshi Enomoto, Harumi Matsuda, Yasuko Konishi, Kentaro Takai, Kengo Tojo, Yoshiharu Uruno, Tomokazu Nakako, Takaaki Sumiyoshi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:5357-5361
We designed and synthesized a series of dihydroquinazolinone derivatives as selective M1 and M4 muscarinic acetylcholine receptors agonists. Introduction of the N-carbethoxy piperidine unit into a HTS hit compound followed by optimization of the amin
Publikováno v:
Journal of Photopolymer Science and Technology. 28:197-200
Autor:
Yoshiharu Uruno, Atsushi Kitamura, Takeshi Enomoto, Akihiko Kiyoshi, Yoshiaki Ochi, Takaaki Sumiyoshi, Yasuko Konishi, Tomokazu Nakako, Atsushi Suwa, Harumi Matsuda, Kentaro Takai, Mutsuko Sakai, Yasuaki Uematsu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:2909-2912
We designed and synthesized novel N-sulfonyl-7-azaindoline derivatives as selective M4 muscarinic acetylcholine receptor agonists. Modification of the N-carbethoxy piperidine moiety of compound 2, an M4 muscarinic acetylcholine receptor (mAChR)-prefe
Autor:
Yoko Takahashi, Yasuaki Uematsu, Mutsuko Sakai, Atsushi Kitamura, Harumi Matsuda, Kentaro Takai, Akihiko Kiyoshi, Takaaki Sumiyoshi, Yasuko Konishi, Tomokazu Nakako, Kengo Tojo, Atsushi Suwa, Yoshiharu Uruno, Takeshi Enomoto
Publikováno v:
ACS Medicinal Chemistry Letters. 4:244-248
Activation of the M1 and M4 muscarinic acetylcholine receptors is thought to play an important role in improving the symptoms of schizophrenia. However, discovery of selective agonists for these receptors has been a challenge, considering the high se
Publikováno v:
Journal of the Japanese Society of Revegetation Technology. 35:194-197
Autor:
Masanori Yamamoto, Keiko Nakamichi, Satoko Baba, Harumi Matsuda, Kenji Matsumoto, Yuji Matsumoto, Taro Kato, Kazuki Yabuuchi, Haruka Nishimuta
Publikováno v:
Pharmacology Research & Perspectives
Enhancement of serotonergic neurotransmission has been the main stream of treatment for patients with depression. However, delayed therapeutic onset and undesirable side effects are major drawbacks for conventional serotonin reuptake inhibitors. Here
Autor:
Atsushi Suwa, Harumi Matsuda, Kentaro Takai, Atsushi Kitamura, Tomokazu Nakako, Yasunao Inoue, Akihiko Kiyoshi, Takeshi Enomoto, Mutsuko Sakai, Gakuji Hashimoto, Yasuko Konishi, Yoshiharu Uruno, Yasuaki Uematsu, Takaaki Sumiyoshi, Hiroyuki Nishikawa
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(14)
We designed and synthesized novel N-substituted 7-azaindoline derivatives as selective M1 and M4 muscarinic acetylcholine receptors (mAChRs) agonists. Hybridization of compound 2 with the HTS hit compound 5 followed by optimization of the N-substitue
Autor:
Kentaro Takai, Atsushi Suwa, Harumi Matsuda, Akihiko Kiyoshi, Takaaki Sumiyoshi, Gakuji Hashimoto, Hiroyuki Nishikawa, Mutsuko Sakai, Yoshiharu Uruno, Takeshi Enomoto, Atsushi Kitamura, Tomokazu Nakako, Yasuaki Uematsu, Yasunao Inoue, Yasuko Konishi
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(16)
We designed and synthesized N-substituted 8-azatetrahydroquinolone derivatives as selective M1 and M4 muscarinic acetylcholine receptors agonists. Optimization of selected derivatives led to the discovery of compound 7 as a highly potent M1 and M4 ag
Autor:
Yutaka Shimada, Harumi Matsuda, Katsumi Umeno, Takashi Itoh, Katsutoshi Terasawa, Naotoshi Shibahara
Publikováno v:
Journal of the Autonomic Nervous System. 61:109-115
This study was designed to evaluate the peripheral circulation response to cold wind stimulation. Skin blood flow (SBF), ECG R-R intervals (RRs) and mean arterial pressure (MAP) were measured in ten healthy men under strictly controlled conditions. C