Výsledky vyhledávání - "Haruko Nagai"

Comparison of immunotoxicity among tetrachloro-, pentachloro-, tetrabromo- and pentabromo-dibenzo-p-dioxins in mice

Autor: Michiyo Matsumoto, Kana Ao, Yoshimi Miyamoto, Hikari Murai, Haruko Nagai, Chiharu Tohyama, Keiko Nohara, Takehiro Suzuki

Publikováno v: Toxicology. 256:25-31

There is concern about the growing environmental levels of brominated dioxins. Brominated dioxins are known to bind and activate the transcription factor aryl hydrocarbon receptor (AhR), as their chlorinated congeners do. However, data on the potency

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::055c6cca3f45f20013e40a0444f03791
https://doi.org/10.1016/j.tox.2008.10.024

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Constitutive activation of the aryl hydrocarbon receptor in T-lineage cells induces thymus involution independently of the Fas/Fas ligand signaling pathway

Autor: Keiko Nohara, Haruko Nagai, Masato Kubo, Masayuki Yamamoto, Ryo Abe

Publikováno v: International Immunopharmacology. 6:279-286

Thymus involution is one of the most prominent consequences of exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). The characteristic features of TCDD-induced thymic changes include reductions in the number of the thymocytes and in the ratio of C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e33ebb56416dcf1f72aae4dc1c0d38b
https://doi.org/10.1016/j.intimp.2005.08.015

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Evaluation of relative potencies of PCB126 and PCB169 for the immunotoxicities in ovalbumin (OVA)-immunized mice

Autor: Tomohiro Ito, Yoko Takeuchi, Keiko Nohara, Chiharu Tohyama, Xiaoqing Pan, Kaoru Inouye, Yuichi Miyabara, Haruko Nagai

Publikováno v: Toxicology. 204:51-60

Dioxin-like polychlorinated biphenyls (PCBs) exert their toxicities by activating the arylhydrocarbon receptor (AhR), a ligand-dependent transcription factor, in a similar manner to the most toxic dioxin, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::239a474995d1c4fc8c7fa08164b5e256
https://doi.org/10.1016/j.tox.2004.06.024

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Long-term Graft Acceptance in Rat Heart Transplantation by CTLA4Ig Gene Transfection Combined with FTY720 Treatment

Autor: Haruko Nagai, Shin Enosawa, Shohei Ogoshi, Masanao Ohba, Yusuke Kita, Seiichi Suzuki, Hiroshi Amemiya, Xiao-Kang Li, Naoko Funeshima, Hui-qi Zhang, Torayuki Okuyama, Shiro Sasaguri

Publikováno v: World Journal of Surgery. 25:391-398

CTLA4Ig strongly adheres to B7 molecules on antigen-presenting cells to block intracellular signal transduction via CD28 on helper T cells, which eventually inhibits immune responses. We have demonstrated that the administration to recipient animals

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a58766242eb17cb95c8db69994ea0933
https://doi.org/10.1007/s002680020071

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Mixture diffusion of sulfonated dyes into cellulose membrane. III. Application of parallel diffusion model to binary system of direct dyes with different affinity

Autor: Haruko Nagai, Kayoko Magara, Masako Maekawa

Publikováno v: Colloids and Surfaces A: Physicochemical and Engineering Aspects. 170:191-198

Mixture diffusion of two dyes (C.I. Direct Blue 15 (DB15) and C.I. Direct Yellow 12 (DY12)) with different affinity onto the substrate into cellulose membrane from the binary solution was studied at 55°C. Uptake curves and concentration–distance p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c75870b7cb8cff1f0835ad7e5887d99b
https://doi.org/10.1016/s0927-7757(00)00549-5

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Organic Chemicals Adsorbed onto Diesel Exhaust Particles Directly Alter the Differentiation of Fetal Thymocytes Through Arylhydrocarbon Receptor but Not Oxidative Stress Responses

Autor: Tomohiro Ito, Haruko Nagai, Keiko Nohara, Tien-Min Lin, Richard E. Peterson, Takahiro Kobayashi, Chiharu Tohyama

Publikováno v: Journal of immunotoxicology. 3(1)

Diesel exhaust particles (DEP) were reported to have adverse effects on the immune system of laboratory animals and to induce thymic involution, particularly when exposure occurred during the fetal or lactational period. DEP consist of a carbon core

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48d6a173672751712d39b7b002c19b3f
https://pubmed.ncbi.nlm.nih.gov/18958682

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Constitutively active aryl hydrocarbon receptor expressed specifically in T-lineage cells causes thymus involution and suppresses the immunization-induced increase in splenocytes

Autor: Keiko Nohara, Yoshiaki Fujii-Kuriyama, Azumi Hida, Xiaoqing Pan, Hozumi Motohashi, Shin-ichi Tsukumo, Haruko Nagai, Chiharu Tohyama, Kaoru Inouye, Masayuki Yamamoto, Tomohiro Ito

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 174(5)

The aryl hydrocarbon receptor (AhR) is a transcription factor belonging to the basic helix-loop-helix-PER-ARNT-SIM superfamily. Xenobiotics, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin, bind the receptor and trigger diverse biological reactions. Thym

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ab2bb0430713bae7530e737e1225580
https://pubmed.ncbi.nlm.nih.gov/15728486

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Search for the target genes involved in the suppression of antibody production by TCDD in C57BL/6 mice

Autor: Chiharu Tohyama, Keiko Nohara, Haruko Nagai, Teiji Takei, Ryo Abe, Masato Kubo

Publikováno v: International immunopharmacology. 5(2)

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) suppresses antibody production through activation of a transcription factor, the aryl hydrocarbon receptor (AhR). To explore the genes that are involved in the suppression of antibody production by TCDD, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::062bebef8b446084ba3bfa8f7c101756
https://pubmed.ncbi.nlm.nih.gov/15652763

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