Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Haruko Miyoshi"'
Autor:
Kei Takedomi, Eiji Kawanishi, Yumi Watanabe, Mayumi Kimura, Koki Kojima, Yoichi Kadoh, Yoshihito Tanaka, Takehiko Matsumura, Kenji Omori, Tamaki Kobayashi, Toshiaki Sakamoto, Haruko Miyoshi, Jun Kotera, Toshiyuki Himiyama, Mitsuya Hongu, Takashi Sasaki, Hiroyuki Taniguchi
Publikováno v:
Chemical and Pharmaceutical Bulletin. 66:243-250
Phosphodiesterase (PDE) 10A is a dual hydrolase of cAMP and cGMP and highly expressed in striatal medium spiny neurons. Inhibition of PDE10A modulates the activity of medium spiny neurons (MSN) via the regulation of cAMP and cGMP. Signal control of M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6843e881235274aefe3a3c26a35ba5a
https://doi.org/10.1248/cpb.c17-00783
https://doi.org/10.1248/cpb.c17-00783
Autor:
Takehiko Matsumura, Hiroyuki Taniguchi, Takashi Sasaki, Misae Takakuwa, Haruko Miyoshi, Yoichi Kadoh, Eiji Kawanishi, Mitsuya Hongu, Yoshihito Tanaka, Yumi Watanabe, Kei Takedomi, Nobuyuki Baba, Yuuki Koizumi, Jun Kotera, Koki Kojima, Itsuko Nakamura
Publikováno v:
Bioorganicmedicinal chemistry. 27(15)
We have developed a new class of PDE10A inhibitor, a pyrazolo[1,5-a]pyrimidine derivative MT-3014 (1). A previous compound introduced was deprioritized due to concerns for E/Z-isomerization and glutathione-adduct formation at the core stilbene struct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bd08f7ec18e9eee0e29fcebbf425ca7
https://pubmed.ncbi.nlm.nih.gov/31235264
https://pubmed.ncbi.nlm.nih.gov/31235264
Autor:
Yoichi, Kadoh, Haruko, Miyoshi, Takehiko, Matsumura, Yoshihito, Tanaka, Mitsuya, Hongu, Mayumi, Kimura, Kei, Takedomi, Kenji, Omori, Jun, Kotera, Takashi, Sasaki, Tamaki, Kobayashi, Hiroyuki, Taniguchi, Yumi, Watanabe, Koki, Kojima, Toshiaki, Sakamoto, Toshiyuki, Himiyama, Eiji, Kawanishi
Publikováno v:
Chemicalpharmaceutical bulletin. 66(3)
Phosphodiesterase (PDE) 10A is a dual hydrolase of cAMP and cGMP and highly expressed in striatal medium spiny neurons. Inhibition of PDE10A modulates the activity of medium spiny neurons (MSN) via the regulation of cAMP and cGMP. Signal control of M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ccbcba61a1f229d7503f09e9a5d3ec06
https://pubmed.ncbi.nlm.nih.gov/29491258
https://pubmed.ncbi.nlm.nih.gov/29491258
Publikováno v:
Angewandte Chemie (International ed. in English). 46(31)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e3e70bc12c615cd822fff10fbca3806
https://pubmed.ncbi.nlm.nih.gov/17615618
https://pubmed.ncbi.nlm.nih.gov/17615618