Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Haruko Kakumitsu"'
Autor:
Kazuya Shimoda, Katsuto Takenaka, Mine Harada, Tadashi Matsuda, Haruko Kakumitsu, Ken Yamamoto, Akihiko Numata, Kenjirou Kamezaki, Takashi Kumano, Fumihiko Ishikawa, Kotaro Shide
Publikováno v:
Leukemia Research. 31:1077-1084
A single somatic mutation, V617F, in the pseudokinase domain of the Jak2 is the primary cause of many chronic myeloproliferative diseases. As valine 617 of Jak2 is conserved as valine 678 of Tyk2, we examined the effect of a homologous mutation in Ty
Autor:
Takashi Haro, Haruko Kakumitsu, Yoshihiro Yamashita, Koutarou Shide, Akihiko Numata, Hisashi Gondo, Hideaki Nakajima, Yasuo Oshima, Kazuya Shimoda, Ken Takase, Hiroyuki Mano, Toshihiro Miyamoto, Kouji Kato, Atsushi Iwama, Mine Harada, Kenjiro Kamezaki, Kenichi Aoki
Publikováno v:
Journal of Biological Chemistry. 280:12621-12629
The Janus kinase (Jak)-Stat pathway plays an essential role in cytokine signaling. Granulocyte colony-stimulating factor (G-CSF) promotes granulopoiesis and granulocytic differentiation, and Stat3 is the principle Stat protein activated by G-CSF. Upo
Publikováno v:
Internal Medicine. 42:98-101
The association of malignancy with nephrotic syndrome and renal histopathologic abnormalities is well documented. We report a case of intravascular lymphomatosis (IVL) presenting as nephrotic syndrome which was diagnosed by renal biopsy. Histological
Autor:
Yuichi Sekine, Mine Harada, Kenjirou Kamezaki, Taisuke Kanaji, Koutarou Shide, Haruko Kakumitsu, Jun Okamura, Akihiko Numata, Seiichi Okamura, Tadashi Matsuda, Hitoshi Nakashima, Yoshiyuki Niho, Toshihiro Yokoyama, Yumi Mizuno, Kazuya Shimoda, Yoshinobu Asano
Publikováno v:
International journal of hematology. 82(1)
We analyzed the structure of the granulocyte colony-stimulating factor (G-CSF) receptor gene in a 6-year-old female patient with severe congenital neutropenia (SCN) who experienced severe recurrent infections since 1 month of age. There is no family
Autor:
Takashi Haro, Haruko Kakumitsu, Tadashi Matsuda, Kazuya Shimoda, Masahiro Yamamoto, Katsuhiro Ogawa, Akihiko Numata, Kenjirou Kamezaki, Masumi Yoshie, Shizuo Akira, Kiyoshi Takeda, Mine Harada
Publikováno v:
Stem cells (Dayton, Ohio). 23(2)
G-CSF specifically stimulates the proliferation and differentiation of cells that are committed to the neutrophil-granulocyte lineage. Although Stat3 was thought to be essential for the transduction of G-CSF-induced cell proliferation and differentia
Autor:
Takashi Haro, Kennosuke Karube, Kazuya Shimoda, Haruko Kakumitsu, Koutarou Shide, Akihiko Numata, Mine Harada, Kenjirou Kamezaki, Kouichi Oshima, Tadashi Matsuda
Publikováno v:
Leukemia research. 29(7)
Thrombopoietin (TPO) regulates megakaryocytopoiesis and platelet production in vivo and in vitro. Exogenous overexpression of TPO in vivo by viral-mediated gene transfer induced bone marrow (BM) fibrosis and osteosclerosis. On the other hand, transge
Autor:
Mine Harada, Yuichi Sekine, Tadashi Matsuda, Akihiko Numata, Kenjirou Kamezaki, Fumihiko Ishikawa, Ryuta Muromoto, Haruko Kakumitsu, Kazuya Shimoda, Takashi Haro
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 173(2)
Receptor for activated C kinase (Rack)-1 is a protein kinase C-interacting protein, and contains a WD repeat but has no enzymatic activity. In addition to protein kinase C, Rack-1 also binds to Src, phospholipase Cγ, and ras-GTPase-activating protei
Autor:
Haruko Kakumitsu, Takashi Haro, Takashi Kumano, Kotaro Shide, Katsuto Takenaka, Kenjirou Kamezaki, Akihiko Numata, Kazuya Shimoda, Mine Harada, Seido Oku
Publikováno v:
Blood. 108:1726-1726
Jak-Stat pathway is essential to transduce cytokine signalings. We previously reported that tyrosine kinase 2 (Tyk2), one of the Jak kinases, was essential but Stat1 was dispensable in IFN-alpha-induced B lymphocyte apoptosis. This indicates the exis
Autor:
Haruko Kakumitsu, Takashi Kumano, Akihiko Numata, Fumihiko Ishikawa, Kenjirou Kamezaki, Kotaro Shide, Kazuya Shimoda, Seido Oku, Katsuto Takenaka, Mine Harada
Publikováno v:
Blood. 108:4888-4888
A single somatic mutation, V617F, in the pseudokinase domain of the Jak2 is the cause of the majority of polycythaemia vera (PV) cases and one-third of essential thrombocythaemia (ET) cases. PV is characterized by an increase in RBC and erythropoiesi
Autor:
Takashi Haro, Haruko Kakumitsu, Kazuya Shimoda, Atsuhiko Numata, Kenjirou Kamezaki, Mine Harada
Publikováno v:
Blood. 104:2184-2184
We recently reported that Tyk2 was essential for IFN-a-induced B lymphocyte growth inhibition, although Stat1 is not required for this IFN-a-mediated inhibition. This means that other signaling molecules besides Stat1, and which are activated by Tyk2