Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Haruko Hayasaka"'
Publikováno v:
PLoS ONE, Vol 19, Iss 5, p e0303910 (2024)
Dach1 is highly expressed in normal podocytes, but this expression rapidly disappears after podocyte injury. To investigate the role of Dach1 in podocytes in vivo, we analyzed global, podocyte-specific, and inducible Dach1 knockout mice. Global Dach1
Externí odkaz:
https://doaj.org/article/720bbf0975db4ec699fc66986eb87c2e
Autor:
Masatsune Tsujioka, Keisuke Miyazawa, Masaki Ohmuraya, Yoichi Nibe, Tetsuya Shirokawa, Haruko Hayasaka, Tsunekazu Mizushima, Takeshi Fukuma, Shigeomi Shimizu
Publikováno v:
Cell Death and Disease, Vol 14, Iss 4, Pp 1-15 (2023)
Abstract Numerous studies have investigated the various cellular responses against genotoxic stress, including those mediated by focal adhesions. We here identified a novel type of focal adhesion remodelling that occurs under genotoxic stress conditi
Externí odkaz:
https://doaj.org/article/858a10e8d67f405eafff4ec2c1efad34
Autor:
Ryonosuke Fujie, Kaoru Kurowarabe, Yuki Yamada, Kakeru Fujiwara, Hayato Nakatani, Kenta Tsutsumi, Ryota Hayashi, Hinami Kawahata, Megumi Miyamoto, Madoka Ozawa, Tomoya Katakai, Yousuke Takahama, Izumi Ohigashi, Haruko Hayasaka
Publikováno v:
Heliyon, Vol 9, Iss 8, Pp e19215- (2023)
The chemokine CCL21 regulates immune and cancer cell migration through its receptor CCR7. The Ccl21a gene encodes the isoform CCL21-Ser, predominantly expressed in the thymic medulla and the secondary lymphoid tissues. This study examined the roles o
Externí odkaz:
https://doaj.org/article/534acb27c84d470f9741f98656fdfbca
Autor:
Arisa Shintani, Shoko Fukai, Reika Nobusawa, Kanako Taniguchi, Tomohiro Hatatani, Hayato Nagai, Tomohiro Sakai, Takuji Yoshimura, Masayuki Miyasaka, Haruko Hayasaka
Publikováno v:
Current Research in Immunology, Vol 3, Iss , Pp 175-185 (2022)
Lymphocytes regulate the immune response by circulating between the vascular and lymphatic systems. High endothelial venules, HEVs, special blood vessels expressing selective adhesion molecules, such as PNAd and MAdCAM-1, mediate naïve lymphocyte mi
Externí odkaz:
https://doaj.org/article/e6168282692643a9bd971a0c57bc3313
Publikováno v:
Biochemistry and Biophysics Reports, Vol 28, Iss , Pp 101128- (2021)
Chemotactic factors locally secreted from tissues regulate leukocyte migration via cell membrane receptors that induce intracellular signals. It has been suggested that neutrophils stimulated by bacterial peptides secrete a secondary stimulant that e
Externí odkaz:
https://doaj.org/article/763465b8e2584899b581d8390b5c74fe
Autor:
Daichi Kobayashi, Yuki Sugiura, Eiji Umemoto, Akira Takeda, Hisashi Ueta, Haruko Hayasaka, Shinsuke Matsuzaki, Tomoya Katakai, Makoto Suematsu, Itaru Hamachi, Gennady G. Yegutkin, Marko Salmi, Sirpa Jalkanen, Masayuki Miyasaka
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Whereas adenosine 5’-triphosphate (ATP) is the major energy source in cells, extracellular ATP (eATP) released from activated/damaged cells is widely thought to represent a potent damage-associated molecular pattern that promotes inflammatory respo
Externí odkaz:
https://doaj.org/article/97740f20ca8d49139c8d35c2edaa2c0f
Autor:
Daichi Kobayashi, Masataka Endo, Hirotaka Ochi, Hironobu Hojo, Masayuki Miyasaka, Haruko Hayasaka
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract The chemokine receptor CCR7 contributes to various physiological and pathological processes including T cell maturation, T cell migration from the blood into secondary lymphoid tissues, and tumor cell metastasis to lymph nodes. Although a pr
Externí odkaz:
https://doaj.org/article/db09bcb04bcd4684b0490d08f757b874
Autor:
Akira Takeda, Daichi Kobayashi, Keita Aoi, Naoko Sasaki, Yuki Sugiura, Hidemitsu Igarashi, Kazuo Tohya, Asuka Inoue, Erina Hata, Noriyuki Akahoshi, Haruko Hayasaka, Junichi Kikuta, Elke Scandella, Burkhard Ludewig, Satoshi Ishii, Junken Aoki, Makoto Suematsu, Masaru Ishii, Kiyoshi Takeda, Sirpa Jalkanen, Masayuki Miyasaka, Eiji Umemoto
Publikováno v:
eLife, Vol 5 (2016)
Lymph nodes (LNs) are highly confined environments with a cell-dense three-dimensional meshwork, in which lymphocyte migration is regulated by intracellular contractile proteins. However, the molecular cues directing intranodal cell migration remain
Externí odkaz:
https://doaj.org/article/8c5064af0fe4434a9e972e595071c07d
Autor:
Haruko Hayasaka, Daichi Kobayashi, Hiromi Yoshimura, Emi E Nakayama, Tatsuo Shioda, Masayuki Miyasaka
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0117454 (2015)
During human immunodeficiency virus (HIV) infection, enhanced migration of infected cells to lymph nodes leads to efficient propagation of HIV-1. The selective chemokine receptors, including CXCR4 and CCR7, may play a role in this process, yet the vi
Externí odkaz:
https://doaj.org/article/c35b21860c794dc89e35a54ec94b7f78
Autor:
Eiji Umemoto, Akira Takeda, Soojung Jin, Zhijuan Luo, Naoki Nakahogi, Haruko Hayasaka, Chun Man Lee, Toshiyuki Tanaka, Masayuki Miyasaka
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e83681 (2013)
Vascular endothelial cells often change their phenotype to adapt to their local microenvironment. Here we report that the vascular endothelial adhesion molecule nepmucin/CD300LG, which is implicated in lymphocyte binding and transmigration, shows uni
Externí odkaz:
https://doaj.org/article/89264e9ee60a4a20a31fb5ec7536f204