Zobrazeno 1 - 10
of 274
pro vyhledávání: '"Haruki Okamura"'
Autor:
Plamena Kabakchieva, Antoaneta Gateva, Tsvetelina Velikova, Tsvetoslav Georgiev, Kyosuke Yamanishi, Haruki Okamura, Zdravko Kamenov
Publikováno v:
Biomedicines, Vol 12, Iss 1, p 222 (2024)
Objective: Polycystic ovary syndrome (PCOS) is a prevalent hormonal and metabolic disorder, wherein the adipose tissue and gut microbiome have been demonstrated to contribute to its pathogenesis. This study aims to assess the concentrations of the ad
Externí odkaz:
https://doaj.org/article/1eecb608bfff40fea2696a86d01c575b
Autor:
Maho Nakashima, Yoshimasa Tanaka, Haruki Okamura, Takeharu Kato, Yoshitaka Imaizumi, Kazuhiro Nagai, Yasushi Miyazaki, Hiroyuki Murota
Publikováno v:
Cells, Vol 13, Iss 2, p 128 (2024)
γδ T cells and natural killer (NK) cells have attracted much attention as promising effector cell subsets for adoptive transfer for use in the treatment of malignant and infectious diseases, because they exhibit potent cytotoxic activity against a
Externí odkaz:
https://doaj.org/article/1dfdb0fe50c84c609a3d5091847efbca
Autor:
Kyosuke Yamanishi, Masaki Hata, Naomi Gamachi, Yuko Watanabe, Chiaki Yamanishi, Haruki Okamura, Hisato Matsunaga
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 24, p 17170 (2023)
Interleukin 18 (IL18) was originally identified as an inflammation-induced cytokine that is secreted by immune cells. An increasing number of studies have focused on its non-immunological functions, with demonstrated functions for IL18 in energy home
Externí odkaz:
https://doaj.org/article/a2421f894b4041709853318f8629496c
Autor:
Kyosuke Yamanishi, Nobutaka Doe, Keiichiro Mukai, Takuya Hashimoto, Naomi Gamachi, Masaki Hata, Yuko Watanabe, Chiaki Yamanishi, Hideshi Yagi, Haruki Okamura, Hisato Matsunaga
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Interleukin-18 (IL18) is an inflammatory cytokine that is related to psychiatric disorders such as depression and cognitive impairment. We previously found that IL18 deficiency may cause hippocampal impairment, resulting in depression-like b
Externí odkaz:
https://doaj.org/article/7e9d891138304446a4c48cacf658a1c5
Autor:
Iveta Nedeva, Antoaneta Gateva, Yavor Assyov, Vera Karamfilova, Julieta Hristova, Kyosuke Yamanishi, Zdravko Kamenov, Haruki Okamura
Publikováno v:
Iranian Journal of Immunology, Vol 19, Iss 2, Pp 199-206 (2022)
Background: Obesity and diabetes are related to a chronic low-grade inflammation. As a pro-inflammatory cytokine, IL-18 stimulates various cell types and has pleiotropic functions. Objective: To assess the levels of IL-18 in subjects from the entire
Externí odkaz:
https://doaj.org/article/2663f3fccc5246388f039142c0c60537
Autor:
Plamena Kabakchieva, Antoaneta Gateva, Tsvetelina Velikova, Tsvetoslav Georgiev, Kyosuke Yamanishi, Haruki Okamura, Zdravko Kamenov
Publikováno v:
Archives of Endocrinology and Metabolism, Vol 66, Iss 1, Pp 3-11 (2022)
ABSTRACT Objective: Our aim was to analyze levels of proinflammatory biomarker interleukin-18 (IL-18) in healthy controls and patients with polycystic ovary syndrome (PCOS) focusing on its association with obesity, clinical, hormonal, and metabolic c
Externí odkaz:
https://doaj.org/article/7bcb54afc7e9433184820f6b317430e0
Autor:
Daisuke Okuno, Noriho Sakamoto, Yoshiko Akiyama, Takatomo Tokito, Atsuko Hara, Takashi Kido, Hiroshi Ishimoto, Yuji Ishimatsu, Mohammed S. O. Tagod, Haruki Okamura, Yoshimasa Tanaka, Hiroshi Mukae
Publikováno v:
Cells, Vol 11, Iss 18, p 2816 (2022)
Idiopathic pulmonary fibrosis is a chronic intractable lung disease, leading to respiratory failure and death. Although anti-fibrotic agents delay disease progression, they are not considered curative treatments, and alternative modalities have attra
Externí odkaz:
https://doaj.org/article/4d25fd21797c489ebc755e37882149fb
Autor:
Kyosuke Yamanishi, Seishi Maeda, Sachi Kuwahara-Otani, Takuya Hashimoto, Kaoru Ikubo, Keiichiro Mukai, Keiji Nakasho, Naomi Gamachi, Yosif El-Darawish, Wen Li, Daisuke Okuzaki, Yuko Watanabe, Hiromichi Yamanishi, Haruki Okamura, Hisato Matsunaga
Publikováno v:
Journal of Translational Medicine, Vol 16, Iss 1, Pp 1-13 (2018)
Abstract Background The cytokine, interleukin-18 (IL-18), was originally identified as an interferon-γ-inducing proinflammatory factor; however, there is increasing evidence suggesting that it has non-immunological effects on physiological functions
Externí odkaz:
https://doaj.org/article/609714639d034e55b30dcb56c9471f8f
Autor:
Kyosuke Yamanishi, Keiichiro Mukai, Takuya Hashimoto, Kaoru Ikubo, Keiji Nakasho, Yosif El-Darawish, Wen Li, Daisuke Okuzaki, Yuko Watanabe, Tetsu Hayakawa, Hiroshi Nojima, Hiromichi Yamanishi, Haruki Okamura, Hisato Matsunaga
Publikováno v:
Journal of Translational Medicine, Vol 16, Iss 1, Pp 1-9 (2018)
Abstract Background The cytokine interleukin-18 was originally identified as an interferon-γ-inducing proinflammatory factor; however, there is increasing evidence to suggest that it has non-immunological effects on physiological functions. We previ
Externí odkaz:
https://doaj.org/article/a94f7a86e1094b818be60b359f52b4a6
Autor:
Emanuela Zaharieva, Zdravko Kamenov, Tsvetelina Velikova, Adelina Tsakova, Yosif El-Darawish, Haruki Okamura
Publikováno v:
Endocrine Connections, Vol 7, Iss 1, Pp 179-185 (2018)
Background: Interleukin-18 (IL-18) is an inflammatory cytokine found to be elevated in obesity, metabolic syndrome and type 2 diabetes (T2D) as a part of the chronic lowgrade inflammatory process in these states. The aim of the study was to evaluat
Externí odkaz:
https://doaj.org/article/ff44a8b8b91244c59f82ea32057813ac