Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Haruka Tsutsui"'
Autor:
Chisato Kaneko, Haruka Tsutsui, Kazuhisa Ozeki, Masaki Honda, Kenta Haraya, Yoshinori Narita, Mika Kamata-Sakurai, Junichi Kikuta, Mitsuyasu Tabo, Masaru Ishii
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract STA551, a novel anti-CD137 switch antibody, binds to CD137 in an extracellular ATP concentration-dependent manner. Although STA551 is assumed to show higher target binding in tumor tissues than in normal tissues, quantitative detection of th
Externí odkaz:
https://doaj.org/article/c4d3885a5dc747a18ef3d9f7eaccf9fa
Publikováno v:
Pharmaceuticals, Vol 15, Iss 5, p 508 (2022)
Therapeutic monoclonal antibodies (mAbs) have been a promising therapeutic approach for several diseases and a wide variety of mAbs are being evaluated in clinical trials. To accelerate clinical development and improve the probability of success, pha
Externí odkaz:
https://doaj.org/article/df203e4d65ad459ea3bf350d1e9f8b11
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. :JPET-AR
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:338-349
Established guidelines have recommended a number of methods based on in vitro data to assess the CYP3A induction risk of new chemical entities in clinical practice. In this study, we evaluated the predictability of various assessment methods. We coll
Autor:
Chisato Kaneko, Haruka Tsutsui, Kazuhisa Ozeki, Masaki Honda, Kenta Haraya, Yoshinori Narita, Mika Kamata-Sakurai, Junichi Kikuta, Mitsuyasu Tabo, Masaru Ishii
STA551, a novel anti-CD137 switch antibody, binds to CD137 in an extracellular ATP (exATP) concentration dependent manner. Although STA551 was assumed to show higher target binding in tumor than normal tissues, quantitative detection of the target bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c42874c8699ef32676a4e1849f880e7
https://doi.org/10.21203/rs.3.rs-1126148/v1
https://doi.org/10.21203/rs.3.rs-1126148/v1
Autor:
Chisato Kaneko, Haruka Tsutsui, Kazuhisa Ozeki, Masaki Honda, Kenta Haraya, Yoshinori Narita, Mika Kamata-Sakurai, Junichi Kikuta, Mitsuyasu Tabo, Masaru Ishii
Publikováno v:
Scientific reports. 12(1)
STA551, a novel anti-CD137 switch antibody, binds to CD137 in an extracellular ATP concentration-dependent manner. Although STA551 is assumed to show higher target binding in tumor tissues than in normal tissues, quantitative detection of the target
Autor:
Haruka Tsutsui, Yasuhiro Kazuki, Miho Ayabe, Tatsuhiko Tachibana, Taiji Miyake, Shoko Takehara, Kayoko Morimoto, Kenta Haraya, Kaoru Kobayashi
Publikováno v:
British journal of pharmacologyREFERENCES. 178(21)
BACKGROUND AND PURPOSE P-glycoprotein (P-gp) exhibits a broad substrate specificity and affects pharmacokinetics, especially intestinal absorption. However, prediction, in vivo, of P-gp-mediated drug-drug interaction (DDI) and non-linear absorption a
Autor:
Motohiro Kato, Hidetoshi Shindoh, Haruka Tsutsui, Nobuo Sekiguchi, Kazuhisa Ozeki, Shino Kuramoto
This is the first report quantitatively evaluating the clinical induction of CYP3A in the liver and the intestine.To evaluate hepatic induction, we collected literature data on endogenous biomarkers of hepatic CYP3A induction which we then used to ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ae35ab178aee404ce1eb01e1cb1794e
Publikováno v:
Pharmaceutical research. 37(1)
Multiple time-point sampling is required in transcellular transport studies to accurately calculate the appropriate efflux ratio (ER). Our study sought to develop a simplified method to determine the ER in Caco-2 cells. The equation for the ER was de
Autor:
Haruka Tsutsui
Publikováno v:
Journal of the Japan Association for Philosophy of Science. 37:59-66