Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Haruka Tsuchiya"'
Publikováno v:
Immunological Medicine, Pp 1-13 (2024)
Single-cell RNA sequencing (scRNA-seq) has transformed our understanding of immune-mediated arthritis, which comprises rheumatoid arthritis and spondyloarthritis. This review outlines the key findings and advancements in scRNA-seq studies focused on
Externí odkaz:
https://doaj.org/article/e01f2c1100104fa68fa8a9edb02e73a9
Autor:
Haruka Tsuchiya, Mineto Ota, Haruka Takahashi, Hiroaki Hatano, Megumi Ogawa, Sotaro Nakajima, Risa Yoshihara, Tomohisa Okamura, Shuji Sumitomo, Keishi Fujio
Publikováno v:
Inflammation and Regeneration, Vol 44, Iss 1, Pp 1-14 (2024)
Abstract Background Current strategies that target cytokines (e.g., tumor necrosis factor (TNF)-α), or signaling molecules (e.g., Janus kinase (JAK)) have advanced the management for allergies and autoimmune diseases. Nevertheless, the molecular mec
Externí odkaz:
https://doaj.org/article/13196c734eea4dd9af939d9a92a133c4
Autor:
Mariko Inoue, Yasuo Nagafuchi, Mineto Ota, Haruka Tsuchiya, Shoko Tateishi, Hiroko Kanda, Keishi Fujio
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract HLA-DRB1 shared epitope risk alleles are the strongest genetic risk factors for rheumatoid arthritis (RA) and potential biomarkers for treatment response to biological disease-modifying antirheumatic drugs (bDMARDs). This study aimed to inve
Externí odkaz:
https://doaj.org/article/56cbc4b0b6a841e8ad9bc7ba693420e6
Autor:
Kensuke Yamaguchi, Kazuyoshi Ishigaki, Akari Suzuki, Yumi Tsuchida, Haruka Tsuchiya, Shuji Sumitomo, Yasuo Nagafuchi, Fuyuki Miya, Tatsuhiko Tsunoda, Hirofumi Shoda, Keishi Fujio, Kazuhiko Yamamoto, Yuta Kochi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Splicing QTL (sQTL), genetic variants regulating alternative splicing, can be biologically important, but complex to detect and interpret. Here, the authors identify sQTL by focusing on protein coding sequences, as an alternative to junction-based ap
Externí odkaz:
https://doaj.org/article/caffc154d21b4e51bfcdf1a24b7faf32
Autor:
Haruka Tsuchiya, Keishi Fujio
Publikováno v:
Immunological Medicine, Vol 45, Iss 1, Pp 27-34 (2022)
Rheumatoid arthritis (RA) is an autoimmune disease characterized by tumor-like hyperplasia and inflammation of the synovium, which causes synovial cell invasion into the bone and cartilage. In RA pathogenesis, various molecules in effector cells (i.e
Externí odkaz:
https://doaj.org/article/94b1a286d8b644be8b99eaeed8833f1a
Publikováno v:
Inflammation and Regeneration, Vol 41, Iss 1, Pp 1-6 (2021)
Abstract Background Rheumatoid arthritis (RA) is an autoimmune disease characterized by tumor-like hyperplasia and inflammation of the synovium, which causes synovial cell invasion into the bone and cartilage. In RA pathogenesis, various molecules in
Externí odkaz:
https://doaj.org/article/e2f83ea43506432284141358ccfda2c0
Autor:
Shuji Sumitomo, Yasuo Nagafuchi, Yumi Tsuchida, Haruka Tsuchiya, Mineto Ota, Kazuyoshi Ishigaki, Akari Suzuki, Yuta Kochi, Keishi Fujio, Kazuhiko Yamamoto
Publikováno v:
Inflammation and Regeneration, Vol 38, Iss 1, Pp 1-5 (2018)
Abstract In the era of precision medicine, transcriptome analysis of whole gene expression is an essential technology. While DNA microarray has a limited dynamic range and a problem of background hybridization, RNA sequencing (RNA-seq) has a broader
Externí odkaz:
https://doaj.org/article/db90aea427ec4d6cba14bb9feb21abcf
Autor:
Haruka Tsuchiya, Keishi Fujio
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 17, p 9534 (2021)
Rheumatoid arthritis (RA) is an autoimmune disease characterized by destructive synovitis. It is significantly associated with disability, impaired quality of life, and premature mortality. Recently, the development of biological agents (including tu
Externí odkaz:
https://doaj.org/article/a40ee192abba4eef9315e3e3de0a5d4b
Autor:
Shinichiro Nakachi, Shuji Sumitomo, Yumi Tsuchida, Haruka Tsuchiya, Masanori Kono, Rika Kato, Keiichi Sakurai, Norio Hanata, Yasuo Nagafuchi, Shoko Tateishi, Hiroko Kanda, Tomohisa Okamura, Kazuhiko Yamamoto, Keishi Fujio
Publikováno v:
Arthritis Research & Therapy, Vol 19, Iss 1, Pp 1-11 (2017)
Abstract Background Regulatory T cells (Tregs) play a role in the suppression of inflammation in autoimmune diseases, and lymphocyte activation gene 3 (LAG3) was reported as a marker of interleukin (IL)-10-producing Tregs. We aimed to clarify the fun
Externí odkaz:
https://doaj.org/article/d50a9a7ed4d849c5ba96b800362642d0
Autor:
Rika Kato, Shuji Sumitomo, Yumi Tsuchida, Haruka Tsuchiya, Shinichiro Nakachi, Keiichi Sakurai, Norio Hanata, Yasuo Nagafuchi, Kanae Kubo, Shoko Tateishi, Hiroko Kanda, Tomohisa Okamura, Kazuhiko Yamamoto, Keishi Fujio
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Systemic lupus erythematosus (SLE) is an autoimmune disease that involves multiple immune cell subsets. We analyzed immune cell subsets in human peripheral blood mononuclear cells (PBMC) in order to identify the cells that are significantly associate
Externí odkaz:
https://doaj.org/article/ad97a887c7e24284bfe1db008aee112a