Elevation of Chemosensitivity of Lung Adenocarcinoma A549 Spheroid Cells by Claudin-2 Knockdown through Activation of Glucose Transport and Inhibition of Nrf2 Signal

Autor: Haruka Nasako, Ayaka Ito, Risa Akizuki, Yuta Yoshino, Akira Ikari, Yui Takashina, Satoshi Endo, Hiroaki Eguchi, Toshiyuki Matsunaga

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 6582, p 6582 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 12

Claudin-2 (CLDN2), a tight junctional protein, is involved in the chemoresistance in a three-dimensional spheroid culture model of human lung adenocarcinoma A549 cells. However, the mechanism has not been fully clarified. We found that the knockdown

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f0fe0a5e7f450478057e16a9552991b
https://pubmed.ncbi.nlm.nih.gov/34205320

Claudin-2 binding peptides, VPDSM and DSMKF, down-regulate claudin-2 expression and anticancer resistance in human lung adenocarcinoma A549 cells

Autor: Yoshinobu Ishikawa, Toshiyuki Matsunaga, Tomohiro Asai, Akira Ikari, Haruka Nasako, Yui Takashina, Risa Akizuki, Mikako Shirouzu, Takehiro Shinoda, Satoshi Endo

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1867:118642

Claudin-2 (CLDN2), a tight junctional protein, is involved in the chemoresistance in spheroid culture models of human lung adenocarcinoma A549 cells. However, there is no chemical which can improve the sensitivity to anticancer drugs. So far, we repo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e1a00c1782bd985f66be868f731f1a1
https://doi.org/10.1016/j.bbamcr.2019.118642