Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Haruka Hirose"'
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 2950-2959 (2023)
The presence of some amino acid mutations in the amino acid sequence that determines a protein’s structure can significantly affect that 3D structure and its biological function. However, the effects upon structural and functional changes differ fo
Externí odkaz:
https://doaj.org/article/f8f1f7c5e38a4f7791b34000f17b9280
Autor:
Akira Nakamizo, Yuichiro Miyamatsu, Haruka Hirose, Toshiyuki Amano, Satoshi Matsuo, Minako Fujiwara, Teppei Shimamura, Koji Yoshimoto
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Glioblastoma is the most common brain tumor with dismal outcomes in adults. Metabolic remodeling is now widely acknowledged as a hallmark of cancer cells, but glioblastoma-specific metabolic pathways remain unclear. Here we show, using a lar
Externí odkaz:
https://doaj.org/article/b6be1e111b754462a0793c2a673efe96
Autor:
Hiroaki Itakura, Tsuyoshi Hata, Daisuke Okuzaki, Koki Takeda, Kenji Iso, Yamin Qian, Yoshihiro Morimoto, Tomohiro Adachi, Haruka Hirose, Yuhki Yokoyama, Takayuki Ogino, Norikatsu Miyoshi, Hidekazu Takahashi, Mamoru Uemura, Tsunekazu Mizushima, Takao Hinoi, Masaki Mori, Yuichiro Doki, Hidetoshi Eguchi, Hirofumi Yamamoto
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106478- (2023)
Summary: Somatic cell reprogramming using the microRNAs miR-200c, miR-302s, and miR-369s leads to increased expression of cyclin-dependent kinase inhibitors in human colorectal cancer (CRC) cells and suppressed tumor growth. Here, we investigated whe
Externí odkaz:
https://doaj.org/article/9a45a3748f274a3eba11f287c9aa056a
Autor:
Satoshi Ishikawa, Donald Kufe, Constantine Mitsiades, Nami Yamashita, Atsushi Fushimi, Atrayee Bhattacharya, Yoshihiro Morimoto, Tatsuaki Daimon, Haruka Hirose, Shizuka Yamano, Naoki Haratake, Rehan Ahmad, Hidekazu Takahashi, Olga Dashevsky
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 2 (2023)
Background The MUC1-C protein evolved in mammals to protect barrier tissues from loss of homeostasis; however, MUC1-C promotes oncogenesis in association with chronic inflammation. Aberrant expression of MUC1-C in cancers has been linked to depletion
Externí odkaz:
https://doaj.org/article/4da912c6510f4d72bcbe786c63f92cda
Autor:
Yuki Ozato, Yasuhiro Kojima, Yuta Kobayashi, Yuuichi Hisamatsu, Takeo Toshima, Yusuke Yonemura, Takaaki Masuda, Kouichi Kagawa, Yasuhiro Goto, Mitsuaki Utou, Mituko Fukunaga, Ayako Gamachi, Kiyomi Imamura, Yuta Kuze, Junko Zenkoh, Ayako Suzuki, Atsushi Niida, Haruka Hirose, Shuto Hayashi, Jun Koseki, Eiji Oki, Satoshi Fukuchi, Kazunari Murakami, Taro Tobo, Satoshi Nagayama, Mamoru Uemura, Takeharu Sakamoto, Masanobu Oshima, Yuichiro Doki, Hidetoshi Eguchi, Masaki Mori, Takeshi Iwasaki, Yoshinao Oda, Tatsuhiro Shibata, Yutaka Suzuki, Teppei Shimamura, Koshi Mimori
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 111929- (2023)
Summary: The cellular interactions in the tumor microenvironment of colorectal cancer (CRC) are poorly understood, hindering patient treatment. In the current study, we investigate whether events occurring at the invasion front are of particular impo
Externí odkaz:
https://doaj.org/article/36523fb8ccbc455a9c49d7317c9ee01e
Autor:
Naoto Tsujimura, Takayuki Ogino, Masayuki Hiraki, Taisei Kai, Hiroyuki Yamamoto, Haruka Hirose, Yuhki Yokoyama, Yuki Sekido, Tsuyoshi Hata, Norikatsu Miyoshi, Hidekazu Takahashi, Mamoru Uemura, Tsunekazu Mizushima, Yuichiro Doki, Hidetoshi Eguchi, Hirofumi Yamamoto
Publikováno v:
Pharmaceuticals, Vol 16, Iss 4, p 618 (2023)
The incidence of inflammatory bowel disease (IBD) is increasing worldwide. It is reported that TGF-β/Smad signal pathway is inactivated in patients with Crohn’s disease by overexpression of Smad 7. With expectation of multiple molecular targeting
Externí odkaz:
https://doaj.org/article/b7086f3b7dce4215a60749c7e4094c66
Publikováno v:
Applied Sciences, Vol 13, Iss 1, p 510 (2022)
Theoretical methods, such as molecular mechanics and molecular dynamics, are very useful in understanding differences in interactions at the single molecule level. In the life sciences, small conformational changes, including substituent modification
Externí odkaz:
https://doaj.org/article/202cff0e47c94f66b02d2adbd13fc839
Autor:
Yu Hara, Jun Tsukiji, Aya Yabe, Yoshika Onishi, Haruka Hirose, Masaki Yamamoto, Makoto Kudo, Takeshi Kaneko, Toshiaki Ebina
Publikováno v:
PLoS ONE, Vol 17, Iss 8, p e0273500 (2022)
Background and objectiveA cytokine storm is caused by inflammatory cells, including pro-inflammatory macrophage phenotype (M1), and play a critical role in the pathogenesis of COVID-19, in which diffuse alveolar damage occurs in the lungs due to oxid
Externí odkaz:
https://doaj.org/article/76cac692b54244e4815df0b304e2afbb
Autor:
Tadafumi Fukata, Tsunekazu Mizushima, Junichi Nishimura, Daisuke Okuzaki, Xin Wu, Haruka Hirose, Yuhki Yokoyama, Yui Kubota, Kazuya Nagata, Naoto Tsujimura, Akira Inoue, Norikatsu Miyoshi, Naotsugu Haraguchi, Hidekazu Takahashi, Taishi Hata, Chu Matsuda, Hisako Kayama, Kiyoshi Takeda, Yuichiro Doki, Masaki Mori, Hirofumi Yamamoto
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 12, Iss , Pp 658-671 (2018)
The incidence of inflammatory bowel disease (IBD) is increasing. Nucleic acid-based medicine has potential as a next-generation treatment, but it is rarely successful with IBD. The aim of this study was to establish a microRNA-based therapy in an IBD
Externí odkaz:
https://doaj.org/article/a357d8bcac204df6adfa5d2c188773cb
Publikováno v:
Photonics, Vol 1, Iss 4, Pp 432-441 (2014)
Modal characteristics of resonantly-guided modes (RGMs) in microstructured fibers were investigated through numerical simulation. The modes of interest are supported in a class of fibers consisting of a circularly arranged periodic array of high inde
Externí odkaz:
https://doaj.org/article/c4d55652b084448b80cada52956ed1f6