Výsledky vyhledávání - "Haruka Furuta"

Akademický článek

Increased expression of glutathione peroxidase 3 prevents tendinopathy by suppressing oxidative stress

Autor: Haruka Furuta, Mari Yamada, Takuya Nagashima, Shuichi Matsuda, Kazuki Nagayasu, Hisashi Shirakawa, Shuji Kaneko

Publikováno v: Frontiers in Pharmacology, Vol 14 (2023)

Tendinopathy, a degenerative disease, is characterized by pain, loss of tendon strength, or rupture. Previous studies have identified multiple risk factors for tendinopathy, including aging and fluoroquinolone use; however, its therapeutic target rem

Externí odkaz: https://doaj.org/article/0011c3608a624e9eac34d97981d6da16

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Akademický článek

Quercetin 3,5,7,3′,4′-pentamethyl ether from Kaempferia parviflora directly and effectively activates human SIRT1

Autor: Mimin Zhang, Peng Lu, Tohru Terada, Miaomiao Sui, Haruka Furuta, Kilico Iida, Yukie Katayama, Yi Lu, Ken Okamoto, Michio Suzuki, Tomiko Asakura, Kentaro Shimizu, Fumihiko Hakuno, Shin-Ichiro Takahashi, Norimoto Shimada, Jinwei Yang, Tsutomu Ishikawa, Jin Tatsuzaki, Koji Nagata

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)

A compound from Thai black ginger, KPMF-8, was previously found to dramatically promote activation of SIRT1 towards a peptide substrate. Zhang et al. now show that KPMF-8 can be taken up by cells through culture media, directly interacts with SIRT1,

Externí odkaz: https://doaj.org/article/5a67ff013a7841da9cbb1ba0d1000592

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Akademický článek

Drug Repurposing Prediction and Validation From Clinical Big Data for the Effective Treatment of Interstitial Lung Disease

Autor: Soni Siswanto, Hiroki Yamamoto, Haruka Furuta, Mone Kobayashi, Takuya Nagashima, Gen Kayanuma, Kazuki Nagayasu, Yumiko Imai, Shuji Kaneko

Publikováno v: Frontiers in Pharmacology, Vol 12 (2021)

Interstitial lung diseases (ILDs) are a group of respiratory disorders characterized by chronic inflammation and fibrosis of the pulmonary interstitial tissues. Although the etiology of ILD remains unclear, some drug treatments are among the primary

Externí odkaz: https://doaj.org/article/104305cb44544327ab22b65762011b32

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The IGF-independent role of IRS-2 in the secretion of MMP-9 enhances the growth of prostate carcinoma cell line PC3

Autor: Fumihiko Hakuno, Haruka Furuta, Yina Sheng, Naoyuki Kataoka, claire perks, Rachel Barker, Shin-Ichiro Takahashi

Insulin receptor substrate-2 (IRS-2), a substrate of the insulin-like growth factor (IGF)-I receptor, is highly expressed in the prostate cancer cell line, PC3s. We recently demonstrated that extracellular signal-regulated kinase (Erk1/2), a kinase d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1b789dab4c5e841e8a5e52ffd44c87b5
https://doi.org/10.21203/rs.3.rs-1955907/v1

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Drug Repurposing Prediction and Validation From Clinical Big Data for the Effective Treatment of Interstitial Lung Disease

Autor: Kazuki Nagayasu, Hiroki Yamamoto, Shuji Kaneko, Soni Siswanto, Yumiko Imai, Mone Kobayashi, Gen Kayanuma, Haruka Furuta, Takuya Nagashima

Publikováno v: Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61ce5ef70d5a4966d555d3d3252747bc
https://www.frontiersin.org/articles/10.3389/fphar.2021.635293/full

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Quercetin 3,5,7,3′,4′-pentamethyl ether from Kaempferia parviflora directly and effectively activates human SIRT1

Autor: Michio Suzuki, Ken Okamoto, Fumihiko Hakuno, Yi Lu, Mimin Zhang, Tsutomu Ishikawa, Shinichiro Takahashi, Peng Lu, Tohru Terada, Kilico Iida, Tomiko Asakura, Yukie Katayama, Norimoto Shimada, Jin Tatsuzaki, Haruka Furuta, Kentaro Shimizu, Koji Nagata, Miaomiao Sui, Jinwei Yang

Publikováno v: Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)

Sirtuin 1 (SIRT1), an NAD+-dependent deacetylase, is a crucial regulator that produces multiple physiological benefits, such as the prevention of cancer and age-related diseases. SIRT1 is activated by sirtuin-activating compounds (STACs). Here, we re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0f6147906664cc68a2a0b4132b2692e
http://europepmc.org/articles/PMC7896056

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IRS-2 deubiquitination by USP9X maintains anchorage-independent cell growth via Erk1/2 activation in prostate carcinoma cell line

Autor: Yosuke Yoneyama, Toshiaki Fukushima, Kazuhiro Chida, Minoru Yoshida, Ada Girnita, Naoyuki Kataoka, Haruka Furuta, Leonard Girnita, Akihiro Ito, Shinichiro Takahashi, C. Worrall, Fumihiko Hakuno, Hidehito Yoshihara, Tomoichiro Asano, Masayuki Komada

Publikováno v: Oncotarget

// Haruka Furuta 1 , Hidehito Yoshihara 1 , Toshiaki Fukushima 2, 3 , Yosuke Yoneyama 1, 6 , Akihiro Ito 4 , Claire Worrall 5 , Ada Girnita 5 , Leonard Girnita 5 , Minoru Yoshida 4 , Tomoichiro Asano 2 , Masayuki Komada 3 , Naoyuki Kataoka 1 , Kazuhi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f92cd1ee7e7b07b11f64663736af7d76
http://europepmc.org/articles/PMC6188063

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