Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Haruka Akahane"'
Autor:
Ryoko Takasawa, Akane Jona, Manami Inoue, Miku Azuma, Haruka Akahane, Yuto Ueno, Yuki Nakagawa, Ryusei Chimori, Yasunari Mano, Yuki Murata, Shuji Yasuike, Toshiyuki Kaji
Publikováno v:
The Journal of toxicological sciences. 47(12)
Organobismuth compounds, i.e., organic-inorganic hybrid molecules composed of an organic structure and bismuth metal, have been reported to induce cytotoxicity in cancer cells; however, the target proteins associated with this cytotoxicity have not b
Autor:
Miku Azuma, Haruka Akahane, Manami Inoue, Masataka Kitajima, Sei-ichi Tanuma, Atsushi Yoshimori, Shunsuke Natani, Hiromi Uchiro, Ryoko Takasawa, Ryusei Chimori, Yasunari Mano, Aya Nishida
Publikováno v:
Bioorganicmedicinal chemistry letters. 40
Glyoxalase I (GLO I) is a known therapeutic target in cancer. Even though TLSC702, a GLO I inhibitor that we discovered, induces apoptosis in tumor cells, exceptionally higher doses are required compared with those needed to inhibit GLO I activity in
Autor:
Atsushi Yoshimori, Hiroko Uchida-Maruki, Masahiko Sai, Haruka Akahane, Nami Shimada, Ryoko Takasawa, Takayuki Yamamoto, Sei-ichi Tanuma, Hikari Tanaka
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(5)
Human glyoxalase I (GLO I), a rate-limiting enzyme for detoxification of methylglyoxal (MG), a by-product of glycolysis, is known to be a potential therapeutic target for cancer. Here, we searched new scaffolds from natural compounds for designing no