Zobrazeno 1 - 10
of 162
pro vyhledávání: '"Haruhiro Okuda"'
Autor:
Hiroko Shibata, Hiroyuki Yoshida, Ken-ichi Izutsu, Chikako Yomota, Yukihiro Goda, Haruhiro Okuda
Publikováno v:
AAPS Open, Vol 2, Iss 1, Pp 1-11 (2016)
Abstract The rapidly growing medical expense going with aging population in Japan requires the use of generic products derived from off-patent active pharmaceutical ingredients (APIs) formulations to reduce the financial burden for the national healt
Externí odkaz:
https://doaj.org/article/b2205ae2870e4f5d995b63cc51038396
Autor:
Hiro Takahashi, Kimie Sai, Yoshiro Saito, Nahoko Kaniwa, Yasuhiro Matsumura, Tetsuya Hamaguchi, Yasuhiro Shimada, Atsushi Ohtsu, Takayuki Yoshino, Toshihiko Doi, Haruhiro Okuda, Risa Ichinohe, Anna Takahashi, Ayano Doi, Yoko Odaka, Misuzu Okuyama, Nagahiro Saijo, Jun-ichi Sawada, Hiromi Sakamoto, Teruhiko Yoshida
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105160 (2014)
Interindividual variation in a drug response among patients is known to cause serious problems in medicine. Genomic information has been proposed as the basis for "personalized" health care. The genome-wide association study (GWAS) is a powerful tech
Externí odkaz:
https://doaj.org/article/c1db012794544cb3b3b8b0dc8cff9f2d
Autor:
Nahoko Uchiyama, Sayaka Masada, Yosuke Demizu, Haruhiro Okuda, Ken-ichi Izutsu, Yukihiro Goda, Naomi Tomita, Hiroyuki Yoshida, Yasuhiro Abe, Takashi Hakamatsuka, Hitomi Kanno, Hidetomo Yokoo, Genichiro Tsuji, Eiichi Yamamoto, Akiko Usui
Publikováno v:
Chemical and Pharmaceutical Bulletin. 68:1008-1012
The purpose of this study was to elucidate the effect of high-temperature storage on the stability of ranitidine, specifically with respect to the potential formation of N-nitrosodimethylamine (NDMA), which is classified as a probable human carcinoge
Autor:
Satoshi Obika, Hideya Kawaji, Yuki Naito, Kiyomi Sasaki, Jun Kawai, Mikihiko Naito, Takao Inoue, Hidenori Yasuhara, Tokuyuki Yoshida, Haruhiro Okuda
Publikováno v:
Genes to Cells
Antisense oligonucleotide (ASO) has the potential to induce off‐target effects due to complementary binding between the ASO and unintended RNA with a sequence similar to the target RNA. Conventional animal studies cannot be used to assess toxicity
Autor:
Ryoko Arai, Takashi Hakamatsuka, Ken-ichi Izutsu, Genichiro Tsuji, Nahoko Uchiyama, Haruhiro Okuda, Yukihiro Goda, Yosuke Demizu, Yasuhiro Abe, Hiroshi Akiyama, Sayaka Masada, Tomoaki Tsutsumi
Publikováno v:
Biological and Pharmaceutical Bulletin. 42:547-551
Valsartan products, commonly used to treat high blood pressure and heart failure, have been recalled in many countries due to the presence of an impurity, N-nitrosodimethylamine (NDMA), in the recalled products. We present and evaluate a GC-MS-based
Autor:
Li Bo, Jarbas Barbosa de Silva Junior, Primal Silva, Hans-Georg Eichler, Chia-Ding Liao, Tara S. Barton-Maclaren, Mary Lou Valdez, Meiruze Freitas, Thalita Antony de Souza Lima, Maurice Whelan, Frank D. Sistare, William Slikker, Shraddha Thakkar, Carl Sactitono, Gary Van Domselaar, Kenneth Lee, Davide Archella, Anil K. Patri, Orish Ebere Orisakwe, Leming Shi, Anna Zhao-Wong, Barry Hardy, Peiying Chuan, Danitza Buvinich, Lit-Hsin Loo, Qasim Chaudhry, Marta Hugas, Haruhiro Okuda, Weida Tong, Hubert Deluyker
Publikováno v:
Regulatory Toxicology and Pharmacology. 98:115-128
Emerging technologies are playing a major role in the generation of new approaches to assess the safety of both foods and drugs. However, the integration of emerging technologies in the regulatory decision-making process requires rigorous assessment
Autor:
Elke Anklam, Marta Hugas, Arnd Hoeveler, Anil K. Patri, Hubert Rauscher, Birgit Sokull-Kluettgen, Haruhiro Okuda, Primal Silva, Jacqueline Allan, Susanne Belz, Weida Tong, William Slikker
Publikováno v:
Regulatory Toxicology and Pharmacology
Nanotechnology and more particularly nanotechnology-based products and materials have provided a huge potential for novel solutions to many of the current challenges society is facing. However, nanotechnology is also an area of product innovation tha
Autor:
Haruhiro Okuda, Yukihiro Goda, Nahoko Uchiyama, Takahiro Goda, Takashi Hakamatsuka, Seiji Tanaka, Tetsuo Iida, Eiichi Yamamoto, Ryoko Arai, Sayaka Masada, Shinnosuke Horie
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 204:114253
A simple and rapid on-line SFE/SFC/quadrupole TOF-MS method to simultaneously analyze active pharmaceutical ingredients and impurities from metered-dose inhalers (MDIs) was developed using ciclesonide MDI (CIC-MDI) as an example. CIC-MDI, as drug Alv
Autor:
Haruhiro Okuda, Tomoko Osawa
Publikováno v:
YAKUGAKU ZASSHI. 140:757-758
Identification of Pseudopolymorphism of Magnesium Stearate by Using Low-Frequency Raman Spectroscopy
Autor:
Yukihiro Goda, James Carriere, Hiroshi Hisada, Haruhiro Okuda, Tatsuo Koide, Randy Heyler, Toshiro Fukami, Motoki Inoue, Noriko Katori
Publikováno v:
Organic Process Research & Development. 20:1906-1910
Magnesium stearate (Mg-St), which is currently available on the market, has a wide variety of properties, including pseudopolymorphism, relative content of stearic acid in fatty acid, and particle size. These properties of Mg-St influence manufacturi