Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Haruhiko Tsumura"'
Autor:
Kousuke Kuroda, Yoshinori Kitagawa, Toshihiro Komeda, Kazuo Kobayashi, Yoshifumi Jigami, Yasunori Chiba, Eiji Mori, Haruhiko Tsumura, Shiro Kataoka, Kazuhiro Motoki
Publikováno v:
FEMS Yeast Research. 7:1307-1316
When human antibody genes were expressed in the methylotrophic yeast Ogataea minuta, the secreted antibody became partially degraded. To suppress the degradation, a vacuolar protease-deficient strain was constructed and its antibody production was ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc6c2451b6d8f176732a88d154242c50
https://doi.org/10.1111/j.1567-1364.2007.00291.x
https://doi.org/10.1111/j.1567-1364.2007.00291.x
Autor:
Keiji Kondo, Toshihiro Komeda, Haruhiko Tsumura, Hiroyuki Honda, Takeshi Kobayashi, Takaharu Hayashi, Kenjiro Kano
Publikováno v:
JOURNAL OF CHEMICAL ENGINEERING OF JAPAN. 36:172-177
Purification of recombinant cathepsin C (CTC) from the fermentation broth of methylotrophic yeast, Candida boidinii was conducted. After centrifugation, fermentation supernatant was processed with four consecutive chromatography columns (cation excha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a37a44e51ea53ab7db8ba1a01b4805a7
https://doi.org/10.1252/jcej.36.172
https://doi.org/10.1252/jcej.36.172
Autor:
Kenjiro Kano, Hirokazu Kikuta, Keiji Kondo, Toshihiro Komeda, Haruhiko Tsumura, Takeshi Kobayashi, Hiroyuki Honda
Publikováno v:
JOURNAL OF CHEMICAL ENGINEERING OF JAPAN. 35:415-420
Bovine cathepsin C production from recombinant methylotrophic yeast, Candida boidinii, was conducted in a jar-fermentor culture of fed-batch mode. Changing the carbon source from glucose to methanol induced cathepsin C expression. After changing the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7cb8dd7076c3c4145ee775f28eea2c1
https://doi.org/10.1252/jcej.35.415
https://doi.org/10.1252/jcej.35.415
Publikováno v:
Bioscience, Biotechnology, and Biochemistry. 64:17-23
Transforming growth factor beta 1 (TGF-beta 1) is a regulator of cell growth and differentiation. It is produced in various of cells and tissues as a biologically latent complex, whose significance is still unknown. We established a Chinese hamster o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::574df045ea386dec017e5e8445dca7a3
https://doi.org/10.1271/bbb.64.17
https://doi.org/10.1271/bbb.64.17
Autor:
Makoto Takeuchi, Hirofumi Arai, Toshiko Kutsukake, Toshinori Watanabe, Hiroyuki Saitoh, Noboru Inoue, Haruhiko Tsumura
Publikováno v:
Glycoconjugate Journal. 16:707-718
Human thrombopoietin (TPO) that regulates the numbers of megakaryocytes and platelets is a heavily N- and O-glycosylated glycoprotein hormone with partial homology to human erythropoietin (EPO). We prepared recombinant human TPO produced in Chinese h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75990f5a385bb005ec703ffbddc63137
https://doi.org/10.1023/a:1007159409961
https://doi.org/10.1023/a:1007159409961
Autor:
Kouichi Takeuch, Takehiko Kamijo, Hirokazu Akiyama, Haruhiko Tsumura, Toshimi Kikuchi, Kenichi Koike, Tadashi Koike, Nobukuni Sawai, Tsukasa Higuchi, Eizaburo Ishii, Atsushi Komiyama
Publikováno v:
Leukemia Research. 21:1097-1106
In normal hematopoiesis, stem cell factor (SCF) stimulates survival, proliferation and differentiation of hematopoietic progenitors. Although SCF acts synergistically with a variety of cytokines, the mechanism of growth factor-cooperation remains to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94c7f9c84189f2437b8a0e7e6ae2033d
https://doi.org/10.1016/s0145-2126(97)00086-6
https://doi.org/10.1016/s0145-2126(97)00086-6
Publikováno v:
STEM CELLS. 15:144-153
Dendritic cells (DC) are a distinct population of leukocytes and specialized antigen-presenting cells for T cell responses. Prior work has shown that GM-CSF can induce the development of large numbers of DC from proliferating progenitors in mouse bon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf877e01c9c0a96ae7c62b0da7d79c60
https://doi.org/10.1002/stem.150144
https://doi.org/10.1002/stem.150144
Autor:
Takanori Muto, Haruhiko Tsumura, Hiroshi Watarai, Toshifumi Mikayama, Yoichi Kato, Ryota Kuroki, Kimishige Ishizaka, Takafumi Tomura
Publikováno v:
Proceedings of the National Academy of Sciences. 93:3007-3010
Glycosylation-inhibiting factor (GIF) is a cytokine that is involved in the regulation of IgE synthesis. The crystal structure of recombinant human GIF was determined by the multiple isomorphous replacement method. The structure was refined to an R f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8f01d8dd27d3a6de4db6b95771bb76e
https://doi.org/10.1073/pnas.93.7.3007
https://doi.org/10.1073/pnas.93.7.3007
Autor:
Mitsuo Nishikawa, Rika Ishikawa, Hideo Inoue, Masatake Osawa, Haruhiko Tsumura, Tadashi Sudo, Nobusuke Nishi
Publikováno v:
STEM CELLS. 13:517-523
It is known that treatment of mice with 5-fluorouracil (5-FU, 150 mg/kg) confers radioprotection. To investigate this effect, we performed bone marrow transplantation (BMT) using C57BL/6-Ly5 congenic mice treated with 5-FU five days prior to experime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7f2607b7e0308c6ce030bdb0abdcf20
https://doi.org/10.1002/stem.5530130509
https://doi.org/10.1002/stem.5530130509
Autor:
Haruhiko Tsumura, Shigeru Matsuki, Katsuhiko Asano, Yuji Okada, Rika Ishikawa, Masaharu Ishikawa
Publikováno v:
Biotechnology Letters. 15:673-678
Recombinant human granulocyte-colony stimulating factor (rhG-CSF) was modified by site-directed mutagenesis and chemical modification in order to improve its pharmacological activity and its thermostability. The mutant rhG CSF which 17th cysteine was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f21c3cbed4b21207a7ab9c4d07872052
https://doi.org/10.1007/bf01080138
https://doi.org/10.1007/bf01080138