Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Haruhiko Kuno"'
Autor:
Atsushi Suzuki, Akiyoshi Kunugi, Yasukazu Tajima, Noriko Suzuki, Motohisa Suzuki, Masashi Toyofuku, Haruhiko Kuno, Satoshi Sogabe, Yohei Kosugi, Yasuyuki Awasaki, Tomohiro Kaku, Haruhide Kimura
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Agonistic profiles of AMPA receptor (AMPA-R) potentiators may be associated with seizure risk and bell-shaped dose-response effects. Here, we report the pharmacological characteristics of a novel AMPA-R potentiator, TAK-653, which exhibits m
Externí odkaz:
https://doaj.org/article/0d63b239f564462aba95ccd87d503257
Autor:
Atsushi Suzuki, Akiyoshi Kunugi, Yasukazu Tajima, Noriko Suzuki, Motohisa Suzuki, Masashi Toyofuku, Haruhiko Kuno, Satoshi Sogabe, Yohei Kosugi, Yasuyuki Awasaki, Tomohiro Kaku, Haruhide Kimura
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-3 (2021)
Externí odkaz:
https://doaj.org/article/8ad097acaf434529807db669202d1f2f
Autor:
Noriko Suzuki, Yasukazu Tajima, Akiyoshi Kunugi, Motohisa Suzuki, Atsushi Suzuki, Satoshi Sogabe, Yasuyuki Awasaki, Tomohiro Kaku, Masashi Toyofuku, Haruhiko Kuno, Haruhide Kimura, Yohei Kosugi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-3 (2021)
Publikováno v:
Japanese Geotechnical Journal. 13:297-308
Autor:
Kyoko Yoshikawa, Ikumi Chisaki, Toshitake Okui, Kazuyoshi Aso, Haruhiko Kuno, Kousuke Hidaka, Tawaraishi Taisuke, Nobuki Sakauchi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:3067-3072
CCR6 has been implicated in both autoimmune diseases and non-autoimmune diseases. Thus, inhibition of CCR6-dependent cell migration is an attractive strategy for their treatment. An orally available small molecule inhibitor of CCR6 could therefore be
Autor:
Junya Shirai, Masato Yoshida, Ayumu Sato, Nobuki Sakauchi, Haruhiko Kuno, Reiko Saikawa, Hideki Furukawa
Publikováno v:
European Journal of Medicinal Chemistry. 139:114-127
A series of phenoxyethylamine derivatives was designed and synthesized to discover potent and selective human α 1D adrenoceptor (α 1D adrenergic receptor; α 1D –AR) antagonists. Compound 7 was taken from our internal compound collection as an at
Autor:
Takashi Santou, Masakuni Kori, Jun Terauchi, Kenjiro Sato, Akira Kaieda, Yoshio Yamamoto, Hideyuki Oki, Hiroshi Nara, Haruhiko Kuno, Naoyuki Kanzaki, Osamu Uchikawa, Hideyuki Mototani, Takako Naito
Publikováno v:
Journal of Medicinal Chemistry. 60:608-626
On the basis of a superposition study of X-ray crystal structures of complexes of quinazoline derivative 1 and triazole derivative 2 with matrix metalloproteinase (MMP)-13 catalytic domain, a novel series of fused pyrimidine compounds which possess a
Autor:
Hironobu Maezaki, Maki Miyamoto, Miki Hara, Norio Tada, Hisashi Fujita, Junya Shirai, Katsuhiko Miwa, Nobuki Sakauchi, Haruhiko Kuno, Nagako Kameoka, Ayumu Sato, Hideki Furukawa
Publikováno v:
Tetrahedron. 72:6334-6339
5-Chloro-1-(5-chloro-2-(methylsulfonyl)benzyl)-2-imino-1,2-dihydropyridine-3-carboxamide hydrochloride (TAK-259) is a novel, selective, and orally active α1D adrenoceptor antagonist with anti-urinary frequency effect. A metabolite (2) of TAK-259 was
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 364(3)
Autor:
Nobuki, Sakauchi, Hideki, Furukawa, Junya, Shirai, Ayumu, Sato, Haruhiko, Kuno, Reiko, Saikawa, Masato, Yoshida
Publikováno v:
European journal of medicinal chemistry. 139
A series of phenoxyethylamine derivatives was designed and synthesized to discover potent and selective human α