Výsledky vyhledávání - "Haruhiko Kouhara"

Gitelman syndrome with a novel frameshift variant in SLC12A3 gene accompanied by chronic kidney disease and type 2 diabetes mellitus

Autor: Motoko Chiga, Masaki Hatanaka, Yosuke Imai, Takayasu Mori, Kenichiro Iio, Shinichi Uchida, Saki Bessho, Eisei Sohara, Haruhiko Kouhara, Jun-ya Kaimori, Hiroki Omori

Publikováno v: CEN Case Rep

Gitelman syndrome is an autosomal recessive genetic disease caused by pathogenic variants in SLC12A3 resulting in the loss of function of the Na–Cl co-transporter (NCC) in the distal tubules. Hypokalemia and diuretic effects can cause secondary typ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1333b08eb127e2e6d21476fab903267e
https://pubmed.ncbi.nlm.nih.gov/34617250

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Plasma aldosterone level within the normal range is less associated with cardiovascular and cerebrovascular risk in primary aldosteronism

Autor: Haruhiko Kouhara, Michio Otsuki, Kunihiko Hashimoto, Daisuke Tamada, Masahiko Murata, Sachi Takeiri, Shogo Kurebayashi, Iichiro Shimomura, Tsunehiko Yamamoto, Reiko D Hayashi, Kosuke Mukai, Toshimitsu Hamasaki, Yoshitaka Kajimoto, Tetsuhiro Kitamura, Makoto Nakao

Publikováno v: Journal of Hypertension. 35:1079-1085

BACKGROUND Previous studies showed higher risk of cardiovascular and cerebrovascular (CCV) events in primary aldosteronism compared with essential hypertension, but the patients of these studies were limited to primary aldosteronism patients with hig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcf7a78e0238de8c60ce255eeadb0db7
https://doi.org/10.1097/hjh.0000000000001251

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Clinical and endocrinological characteristics of adrenal incidentaloma in Osaka region, Japan

Autor: Keisuke Kosugi, Akihisa Imagawa, Soji Kasayama, Mamiko Tsugawa, Michio Otsuki, Shogo Kurebayashi, Haruhiko Kouhara, Tsunehiko Yamamoto, Tohru Funahashi, Tadashi Nakamura, Iichiro Shimomura, Taka-aki Matsuoka, Hideki Taki, Makoto Ohashi, Ikuo Mineo, Yuya Yamada, Yutaka Umayahara, Kunihiko Hashimoto, Yukiko Tabuchi

Publikováno v: Endocrine Journal. 63:29-35

The aim of this study was to investigate the clinical and endocrinological characteristics of adrenal incidentalomas in Osaka region, Japan. The study was a multicenter retrospective analysis of 150 patients with adrenal incidentalomas who underwent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::510c7f40f6d299f5ec200f2d71c90569
https://doi.org/10.1507/endocrj.ej15-0404

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Effects of Pitavastatin on Serum Lipids and High Sensitivity C-Reactive Protein in Type 2 Diabetic Patients

Autor: Soji Kasayama, Makoto Nakao, Shogo Kurebayashi, Maki Okamoto, Bunzo Sato, Kazumasa Nshii, Satoru Sumitani, Kunihiko Hashimoto, Haruhiko Kouhara, Miki Takagi, Hiroyasu Yamamoto, Tetsuhiro Kitamura, Michio Otsuki, Hiroshi Saito, Yasuhiko Morimoto, Masafumi Koga, Nobuyuki Asanuma, Takashi Motomura

Publikováno v: Journal of Atherosclerosis and Thrombosis. 16:546-552

Aim: Previous studies have been inconsistent results about the effects of statins on serum triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and high sensitivity C-reactive protein (hsCRP) levels. We therefore investigated the effects o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71240e41559d9004265bfe1fa4c45b7b
https://doi.org/10.5551/jat.992

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The thiazolidinedione drug troglitazone up-regulates nitric oxide synthase expression in vascular endothelial cells

Autor: Haruhiko Kouhara, Hiroyasu Yamamoto, Xin Xu, Shogo Kurebayashi, Kayoko Goya, Hiroshi Saito, Soji Kasayama, Michio Otsuki, Satoru Sumitani

Publikováno v: Journal of Diabetes and its Complications. 20:336-342

Endothelial dysfunction is a phenomenon often observed in diabetic patients, which is a cause for vascular complications of diabetes mellitus. Endothelium-derived nitric oxide (NO) is responsible for vasodilatation, and NO-dependent vasodilatation is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18ea3d2a4c62eb8c47aab568d1d963aa
https://doi.org/10.1016/j.jdiacomp.2005.08.003

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Reduction of a Pancreatic Tumor after Total Removal of an ACTH Secreting Pituitary Tumor: Differential Diagnosis of Cushing's Syndrome

Autor: Soji Kasayama, Toshiki Yoshimine, Tomoyuki Maruo, Toshiyuki Fujinaka, Haruhiko Kouhara, Youichi Saitoh, Nobuyuki Asanuma, Tetsuo Hashiba

Publikováno v: Endocrine Journal. 53:203-208

Endocrinologic tests sometimes fail to distinguish adrenocorticotropic hormone (ACTH)-secreting pituitary adenoma from ectopic ACTH-secreting tumor. The authors experienced a case of Cushing's disease associated with a pancreatic tumor. Venous sampli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0ac74c0b1a784c24b1a358bf527eb3a
https://doi.org/10.1507/endocrj.53.203

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A novel thiazolidinedione MCC-555 down-regulates tumor necrosis factor-α-induced expression of vascular cell adhesion molecule-1 in vascular endothelial cells

Autor: Shogo Kurebayashi, Soji Kasayama, Muneshige Shiraishi, Xin Xu, Haruhiko Kouhara, Shinichi Ishii

Publikováno v: Atherosclerosis. 182:71-77

Thiazolidinediones (TZDs) are anti-diabetic agents that enhance insulin sensitivity through activating peroxisome proliferator-activated receptor (PPAR) gamma. Besides their glucose-lowering effects, TZDs are shown to exhibit anti-inflammatory proper

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::342195acc9ec7cfff4551fda09432c63
https://doi.org/10.1016/j.atherosclerosis.2005.02.004

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Suppressor of cytokine signaling 1 suppresses muscle differentiation through modulation of IGF-I receptor signal transduction

Autor: Satoru Sumitani, Haruhiko Kouhara, Tadamitsu Kishimoto, Toshio Tanaka, Hiroshi Saito, Makiko Inaba, Tetsuji Naka, Tomoharu Ohkawara, Minoru Fujimoto, Soji Kasayama, Ichiro Kawase

Publikováno v: Biochemical and Biophysical Research Communications. 328:953-961

Suppressor of cytokine signaling (SOCS) 1 was initially identified as an intracellular negative feedback regulator of the JAK-STAT signal pathway. Recently, it has been suggested that SOCS1 affects signals of growth factors and hormones. One of them,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::931f39fc91dc764b0545fa735a10e976
https://doi.org/10.1016/j.bbrc.2005.01.046

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RU486 antagonizes the inhibitory effect of peroxisome proliferator-activated receptor α on interleukin-6 production in vascular endothelial cells

Autor: Haruhiko Kouhara, Soji Kasayama, Michio Otsuki, Xin Xu, Hiroshi Saito, Satoru Sumitani

Publikováno v: The Journal of Steroid Biochemistry and Molecular Biology. 81:141-146

Peroxisome proliferator-acitivated receptor alpha (PPARalpha) is a member of nuclear receptor superfamily. Recent studies have shown that the activators for PPARalpha inhibit the expression of some inflammatory molecules in vascular endothelial cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::040569784ee0fb4b474baaa6cb047caa
https://doi.org/10.1016/s0960-0760(02)00055-9

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