Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Haruhiko Kosek"'
Autor:
Shih-Yun Chen, Tse-En Wang, Wei-Yun Lee, Ya-Yi Yang, Hong-Chun Lai, Fuko Matsuda, Haruhiko Kosek, You-Tzung Chen, Sheng-Hsiang Li, Pei-Shiue Tsai
Publikováno v:
Journal of Ovarian Research, Vol 17, Iss 1, Pp 1-13 (2024)
Abstract Background Quiescin sulfhydryl oxidase 2 (QSOX2) is a flavin adenine dinucleotide-dependent sulfhydryl oxidase that is known to be involved in protein folding, cell growth regulation, and redox state modification through oxidative activities
Externí odkaz:
https://doaj.org/article/e97a3d438afd49a59d8b4328358b2c73
Autor:
Satoshi Kaito, Kazumasa Aoyama, Motohiko Oshima, Akiho Tsuchiya, Makiko Miyota, Masayuki Yamashita, Shuhei Koide, Yaeko Nakajima-Takagi, Hiroko Kozuka-Hata, Masaaki Oyama, Takao Yogo, Tomohiro Yabushita, Ryoji Ito, Masaya Ueno, Atsushi Hirao, Kaoru Tohyama, Chao Li, Kimihito Cojin Kawabata, Kiyoshi Yamaguchi, Yoichi Furukawa, Hidetaka Kosako, Akihide Yoshimi, Susumu Goyama, Yasuhito Nannya, Seishi Ogawa, Karl Agger, Kristian Helin, Satoshi Yamazaki, Haruhiko Koseki, Noriko Doki, Yuka Harada, Hironori Harada, Atsuya Nishiyama, Makoto Nakanishi, Atsushi Iwama
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract DNA hypomethylating agents (HMAs) are used for the treatment of myeloid malignancies, although their therapeutic effects have been unsatisfactory. Here we show that CRISPR-Cas9 screening reveals that knockout of topoisomerase 1-binding argin
Externí odkaz:
https://doaj.org/article/d5c4ccd82b76400cb577a39dab027bde
Autor:
Tazro Ohta, Ayaka Hananoe, Ayano Fukushima-Nomura, Koichi Ashizaki, Aiko Sekita, Jun Seita, Eiryo Kawakami, Kazuhiro Sakurada, Masayuki Amagai, Haruhiko Koseki, Hiroshi Kawasaki
Publikováno v:
Allergology International, Vol 73, Iss 2, Pp 255-263 (2024)
Background: In clinical research on multifactorial diseases such as atopic dermatitis, data-driven medical research has become more widely used as means to clarify diverse pathological conditions and to realize precision medicine. However, modern cli
Externí odkaz:
https://doaj.org/article/ee67cf18d7e74b9e9dd9424099c63075
Autor:
Alise Zagare, German Preciat, Sarah. L. Nickels, Xi Luo, Anna S. Monzel, Gemma Gomez-Giro, Graham Robertson, Christian Jaeger, Jafar Sharif, Haruhiko Koseki, Nico J. Diederich, Enrico Glaab, Ronan M. T. Fleming, Jens C. Schwamborn
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract The vast majority of Parkinson’s disease cases are idiopathic. Unclear etiology and multifactorial nature complicate the comprehension of disease pathogenesis. Identification of early transcriptomic and metabolic alterations consistent acr
Externí odkaz:
https://doaj.org/article/1c777ab6bc7a41ed91833568c4533468
Autor:
Aiko Sekita, Hiroshi Kawasaki, Ayano Fukushima-Nomura, Kiyoshi Yashiro, Keiji Tanese, Susumu Toshima, Koichi Ashizaki, Tomohiro Miyai, Junshi Yazaki, Atsuo Kobayashi, Shinichi Namba, Tatsuhiko Naito, Qingbo S. Wang, Eiryo Kawakami, Jun Seita, Osamu Ohara, Kazuhiro Sakurada, Yukinori Okada, Masayuki Amagai, Haruhiko Koseki
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Atopic dermatitis (AD) is a skin disease that is heterogeneous both in terms of clinical manifestations and molecular profiles. It is increasingly recognized that AD is a systemic rather than a local disease and should be assessed in the con
Externí odkaz:
https://doaj.org/article/a3febd05fa144c68a981cadc89884897
Autor:
Nando D. Das, Jen-Chien Chang, Chung-Chau Hon, S. Thomas Kelly, Shinsuke Ito, Marina Lizio, Bogumil Kaczkowski, Hisami Watanabe, Keisuke Katsushima, Atsushi Natsume, Haruhiko Koseki, Yutaka Kondo, Aki Minoda, Takashi Umehara
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-19 (2023)
Abstract Background Super-enhancers (SEs), which activate genes involved in cell-type specificity, have mainly been defined as genomic regions with top-ranked enrichment(s) of histone H3 with acetylated K27 (H3K27ac) and/or transcription coactivator(
Externí odkaz:
https://doaj.org/article/5b74b7e87b6c485084dc2c0220e913a3
Autor:
So Maezawa, Masashi Yukawa, Kazuteru Hasegawa, Ryo Sugiyama, Mizuho Iizuka, Mengwen Hu, Akihiko Sakashita, Miguel Vidal, Haruhiko Koseki, Artem Barski, Tony DeFalco, Satoshi H. Namekawa
Publikováno v:
Cell Death and Disease, Vol 14, Iss 8, Pp 1-12 (2023)
Abstract Gonadal sex determination and differentiation are controlled by somatic support cells of testes (Sertoli cells) and ovaries (granulosa cells). In testes, the epigenetic mechanism that maintains chromatin states responsible for suppressing fe
Externí odkaz:
https://doaj.org/article/aa478729c1c142cc857ac4f13d7a9ee7
Publikováno v:
Inflammation and Regeneration, Vol 43, Iss 1, Pp 1-10 (2023)
Abstract Invariant natural killer T (iNKT) cells are a subset of innate-like T cells restricted by a major histocompatibility complex (MHC) class I-like molecule, CD1d. iNKT cells express an invariant T cell receptor (TCR) encoded by Vα14 Jα18 in m
Externí odkaz:
https://doaj.org/article/31b30f897d6a4a2281f562049a72699d
Publikováno v:
Bio-Protocol, Vol 13, Iss 22 (2023)
The blastocysts consist of dozens of cells of three distinct lineages: epiblast (Epi), trophoblast (TB), and primitive endoderm (PrE). All embryonic and extraembryonic tissues are derived from Epi, TB, and PrE. Stem cell lines representing preimplant
Externí odkaz:
https://doaj.org/article/e82d600349a148e086a0b0dbf353d34e
Autor:
Haruhiko Koseki, Lilin Zhang, Yuji Mishima, Akane Urakami, Koichiro Shioya, Tomokuni Shigeura, Tomio Matsumura, Momoko Okoshi
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/5c630998c46348ef932a46bf3795d704