Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Haruhiko Banno"'
Autor:
Kazunari Onodera, Daisuke Shimojo, Yasuharu Ishihara, Masato Yano, Fuyuki Miya, Haruhiko Banno, Naoko Kuzumaki, Takuji Ito, Rina Okada, Bruno de Araújo Herculano, Manabu Ohyama, Mari Yoshida, Tatsuhiko Tsunoda, Masahisa Katsuno, Manabu Doyu, Gen Sobue, Hideyuki Okano, Yohei Okada
Publikováno v:
Molecular Brain, Vol 13, Iss 1, Pp 1-15 (2020)
Abstract Spinal bulbar muscular atrophy (SBMA) is an adult-onset, slowly progressive motor neuron disease caused by abnormal CAG repeat expansion in the androgen receptor (AR) gene. Although ligand (testosterone)-dependent mutant AR aggregation has b
Externí odkaz:
https://doaj.org/article/c9f6034e190445819b495df34c6fae53
Autor:
Hidekazu Tomimoto, Takayuki Kondo, Yoshihide Sunada, Hidehiro Ishikawa, Akihiro Shindo, Yuishin Izumi, Haruhiko Banno, Satoshi Morita, Koji Fujita, Ryosuke Takahashi, Haruhisa Inoue, Takakuni Maki, Toshifumi Watanabe, Kenji Ishii, Manabu Ikeda, Taro Okunomiya, Yoko Amino, Kayoko Endo, Akiyoshi Nakakura, Akemi Kinoshita, Harue Tada, Ken Yasuda, Yosuke Taruno, Takashi Suehiro, Kohji Mori, Kazutomi Kanemaru, Kazue Shigenobu, Yumiko Kutoku, Shinobu Kawakatsu, Shunji Shiota, Osamu Uchikawa
Publikováno v:
BMJ Open, Vol 11, Iss 6 (2021)
Introduction Alzheimer’s disease (AD) is one of the most common causes of dementia. Pathogenic variants in the presenilin 1 (PSEN1) gene are the most frequent cause of early-onset AD. Medications for patients with AD bearing PSEN1 mutation (PSEN1-A
Externí odkaz:
https://doaj.org/article/5a95f19b8f854322a9c17d2f1445538b
Ibudilast (MN-166) in amyotrophic lateral sclerosis- an open label, safety and pharmacodynamic trial
Autor:
Suma Babu, Baileigh G. Hightower, James Chan, Nicole R. Zürcher, Pia Kivisäkk, Chieh-En J. Tseng, Danica L. Sanders, Ashley Robichaud, Haruhiko Banno, Armineuza Evora, Akshata Ashokkumar, Lindsay Pothier, Sabrina Paganoni, Sheena Chew, Joanna Dojillo, Kazuko Matsuda, Mark Gudesblatt, James D. Berry, Merit E. Cudkowicz, Jacob M Hooker, Nazem Atassi
Publikováno v:
NeuroImage: Clinical, Vol 30, Iss , Pp 102672- (2021)
Ibudilast (MN-166) is an inhibitor of macrophage migration inhibitory factor (MIF) and phosphodiesterases 3,4,10 and 11 (Gibson et al., 2006; Cho et al., 2010). Ibudilast attenuates CNS microglial activation and secretion of pro-inflammatory cytokine
Externí odkaz:
https://doaj.org/article/6307ae02502a42e6a2a3542ec44d074d
Autor:
Shinichiro Yamada, Atsushi Hashizume, Yasuhiro Hijikata, Tomonori Inagaki, Keisuke Suzuki, Naohide Kondo, Kaori Kawai, Seiya Noda, Hirotaka Nakanishi, Haruhiko Banno, Akihiro Hirakawa, Haruki Koike, Katherine Halievski, Cynthia L Jordan, Masahisa Katsuno, Gen Sobue
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0168846 (2016)
The aim of this study was to characterize the respiratory function profile of subjects with spinal and bulbar muscular atrophy (SBMA), and to explore the underlying pathological mechanism by comparing the clinical and biochemical indices of this dise
Externí odkaz:
https://doaj.org/article/fa8db99cc84d4fea8bad2d8c621c3533
Publikováno v:
International Journal of Molecular Sciences, Vol 10, Iss 3, Pp 1000-1012 (2009)
Spinal and bulbar muscular atrophy (SBMA) is a hereditary motor neuron disease caused by the expansion of a polyglutamine tract in the androgen receptor (AR). The histopathological finding in SBMA is loss of lower motor neurons in the anterior horn o
Externí odkaz:
https://doaj.org/article/b15635c901d64734a7fbc48ee9fb8d4c
Publikováno v:
Neural Plasticity, Vol 2012 (2012)
Spinal and bulbar muscular atrophy (SBMA) is the first member identified among polyglutamine diseases characterized by slowly progressive muscle weakness and atrophy of the bulbar, facial, and limb muscles pathologically associated with motor neuron
Externí odkaz:
https://doaj.org/article/eb5fb181d91c4e3189c4c491d60d93bb
Autor:
Janice A. Dominov, Laura A. Madigan, Joshua P. Whitt, Katerina L. Rademacher, Kristin M. Webster, Hesheng Zhang, Haruhiko Banno, Siqi Tang, Yifan Zhang, Nicholas Wightman, Emma M. Shychuck, John Page, Alexandra Weiss, Karen Kelly, Alper Kucukural, Michael H. Brodsky, Alexander Jaworski, Justin R. Fallon, Diane Lipscombe, Robert H. Brown
Publikováno v:
bioRxiv
Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disorder affecting brain and spinal cord motor neurons. Mutations in the copper/zinc superoxide dismutase gene (SOD1) are associated with ∼20% of inherited and 1-2% of sporadic ALS c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0de160fc2e91574d01f7d30c4af0729
https://doi.org/10.1101/2023.05.05.539444
https://doi.org/10.1101/2023.05.05.539444
Autor:
Yasuhiro Hijikata, Keisuke Suzuki, Masahisa Katsuno, Gen Sobue, Atsushi Hashizume, Shinichiro Yamada, Daisuke Ito, Haruhiko Banno
Publikováno v:
Internal Medicine
Spinal and bulbar muscular atrophy (SBMA) is a progressive hereditary neuromuscular disease caused by the testosterone-dependent accumulation of pathogenic polyglutamine-expanded androgen receptor protein. A 41-year-old man with SBMA received the and
Ibudilast (MN-166) in amyotrophic lateral sclerosis- an open label, safety and pharmacodynamic trial
Autor:
Baileigh G. Hightower, Sabrina Paganoni, Joanna Dojillo, Mark Gudesblatt, Armineuza Evora, Ashley Robichaud, Sheena Chew, Lindsay Pothier, Nicole R. Zürcher, Jacob M. Hooker, Haruhiko Banno, Pia Kivisäkk, Suma Babu, Nazem Atassi, Kazuko Matsuda, Akshata Ashokkumar, Chieh-En Jane Tseng, James Chan, James D. Berry, Merit Cudkowicz, Danica L. Sanders
Publikováno v:
NeuroImage: Clinical, Vol 30, Iss, Pp 102672-(2021)
Ibudilast (MN-166) is an inhibitor of macrophage migration inhibitory factor (MIF) and phosphodiesterases 3,4,10 and 11 (Gibson et al., 2006; Cho et al., 2010). Ibudilast attenuates CNS microglial activation and secretion of pro-inflammatory cytokine
Autor:
Haruhiko Banno, Takuji Ito, Tatsuhiko Tsunoda, Yohei Okada, Yasuharu Ishihara, Hideyuki Okano, Mari Yoshida, Daisuke Shimojo, Masahisa Katsuno, Masato Yano, Manabu Ohyama, Fuyuki Miya, Kazunari Onodera, Bruno Herculano, Naoko Kuzumaki, Rina Okada, Gen Sobue, Manabu Doyu
Publikováno v:
Molecular Brain, Vol 13, Iss 1, Pp 1-15 (2020)
Molecular Brain
Molecular Brain
Spinal bulbar muscular atrophy (SBMA) is an adult-onset, slowly progressive motor neuron disease caused by abnormal CAG repeat expansion in the androgen receptor (AR) gene. Although ligand (testosterone)-dependent mutant AR aggregation has been shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::016976c18b3f1058978c296cb499874d
https://doi.org/10.21203/rs.2.20096/v2
https://doi.org/10.21203/rs.2.20096/v2